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    CACNG2 calcium voltage-gated channel auxiliary subunit gamma 2 [ Homo sapiens (human) ]

    Gene ID: 10369, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    TARPgamma2 Is Required for Normal AMPA Receptor Expression and Function in Direction-Selective Circuits of the Mammalian Retina.

    TARPγ2 Is Required for Normal AMPA Receptor Expression and Function in Direction-Selective Circuits of the Mammalian Retina.
    Stincic T, Gayet-Primo J, Taylor WR, Puthussery T., Free PMC Article

    08/17/2023
    Association between CACNG2 polymorphisms (rs4820242, rs2284015 and rs2284017) and chronic peripheral neuropathic pain risk in a Mexican population.

    Association between CACNG2 polymorphisms (rs4820242, rs2284015 and rs2284017) and chronic peripheral neuropathic pain risk in a Mexican population.
    Mejía-Terrazas GE, López-Muñoz E, Hidalgo-Bravo A, Santamaria-Olmedo MG, Valdés-Flores M.

    07/16/2022
    The results of this study conclude that the A-C-C haplotype at the 3 single-nucleotide polymorphisms (rs4820242, rs2284015, and rs2284017) in the CACNG2 gene is associated with increased risk of developing Chronic postmastectomy pain.

    CACNG2 polymorphisms associate with chronic pain after mastectomy.
    Bortsov AV, Devor M, Kaunisto MA, Kalso E, Brufsky A, Kehlet H, Aasvang E, Bittner R, Diatchenko L, Belfer I., Free PMC Article

    06/29/2019
    Lithium response in Bipolar Disorder was significantly associated with single nucleotide polymorphism in CACNG2 in both the prospective and retrospective cohorts.

    Study of 45 candidate genes suggests CACNG2 may be associated with lithium response in bipolar disorder.
    Miranda A, Shekhtman T, McCarthy M, DeModena A, Leckband SG, Kelsoe JR., Free PMC Article

    05/18/2019
    TARP gamma-2 reduces the ability of low glutamate concentrations to cause AMPAR desensitization and enhances channel gating at low glutamate occupancy.

    Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.
    Coombs ID, MacLean DM, Jayaraman V, Farrant M, Cull-Candy SG., Free PMC Article

    04/21/2018
    Our nanopositioning data place stargazin below the AMPA receptor ligand-binding domain, where it is well poised to act as a scaffold to facilitate the long-range conformational selection observations seen in single-molecule experiments. These data support a model of stargazin acting to stabilize or select conformational states that favor activation.

    Stargazin Modulation of AMPA Receptors.
    Shaikh SA, Dolino DM, Lee G, Chatterjee S, MacLean DM, Flatebo C, Landes CF, Jayaraman V., Free PMC Article

    12/2/2017
    In addition to changes in MEK3 gene regulation, our study demonstrated upregulation of CACNG2 and GADD45G at the mRNA level in CMM patients.

    Molecular Changes Involving MEK3-p38 MAPK Activation in Chronic Masticatory Myalgia.
    Meng H, Gao Y, Kang YF, Zhao YP, Yang GJ, Wang Y, Cao Y, Gan YH, Xie QF.

    05/13/2017
    A transient positive feedback mechanism between AMPAR and stargazin has implications for information processing in the brain, because it should allow activity-dependent facilitation of excitatory synaptic transmission through a postsynaptic mechanism.

    Superactivation of AMPA receptors by auxiliary proteins.
    Carbone AL, Plested AJ., Free PMC Article

    05/21/2016
    The additional cleft closure and/or stabilization of the more closed-cleft states of the LBD is expected to translate to higher agonist efficacy and could contribute to the structural mechanism for stargazin modulation of AMPAR function.

    Stargazin promotes closure of the AMPA receptor ligand-binding domain.
    MacLean DM, Ramaswamy SS, Du M, Howe JR, Jayaraman V., Free PMC Article

    07/25/2015
    Autoinactivation is a subunit and splice form dependent property of AMPA receptor-stargazin complexes, which involves structural rearrangements within the complex rather than any physical dissociation.

    Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation.
    Semenov A, Möykkynen T, Coleman SK, Korpi ER, Keinänen K., Free PMC Article

    05/11/2013
    Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2

    Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2.
    Nissenbaum J, Devor M, Seltzer Z, Gebauer M, Michaelis M, Tal M, Dorfman R, Abitbul-Yarkoni M, Lu Y, Elahipanah T, delCanho S, Minert A, Fried K, Persson AK, Shpigler H, Shabo E, Yakir B, Pisanté A, Darvasi A., Free PMC Article

    01/1/2011
    Data show that S-nitrosylation of stargazin increases binding to the AMPAR subunit GluR1, causing increased surface expression of the AMPAR.

    S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors.
    Selvakumar B, Huganir RL, Snyder SH., Free PMC Article

    01/21/2010
    findings show stargazin demonstrates differential control of AMPA receptor subunit stability

    Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution.
    Kessels HW, Kopec CD, Klein ME, Malinow R., Free PMC Article

    01/21/2010
    The genes CACNG2 might be vulnerability genes for neuropsychologically defined subgroups of schizophrenic patients.

    RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function.
    Liu YL, Fann CS, Liu CM, Chen WJ, Wu JY, Hung SI, Chen CH, Jou YS, Liu SK, Hwang TJ, Hsieh MH, Chang CC, Yang WC, Lin JJ, Chou FH, Faraone SV, Tsuang MT, Hwu HG, Liu YL, Fann CS, Liu CM, Chen WJ, Wu JY, Hung SI, Chen CH, Jou YS, Liu SK, Hwang TJ, Hsieh MH, Chang CC, Yang WC, Lin JJ, Chou FH, Faraone SV, Tsuang MT, Hwu HG.

    01/21/2010
    Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
    Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB., Free PMC Article

    02/11/2009
    Stargazin polymorphisms may play a role in the response to lithium treatment.

    Stargazin involvement with bipolar disorder and response to lithium treatment.
    Silberberg G, Levit A, Collier D, St Clair D, Munro J, Kerwin RW, Tondo L, Floris G, Breen G, Navon R, Silberberg G, Levit A, Collier D, St Clair D, Munro J, Kerwin RW, Tondo L, Floris G, Breen G, Navon R.

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)

    RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function.
    Liu YL, Fann CS, Liu CM, Chen WJ, Wu JY, Hung SI, Chen CH, Jou YS, Liu SK, Hwang TJ, Hsieh MH, Chang CC, Yang WC, Lin JJ, Chou FH, Faraone SV, Tsuang MT, Hwu HG, Liu YL, Fann CS, Liu CM, Chen WJ, Wu JY, Hung SI, Chen CH, Jou YS, Liu SK, Hwang TJ, Hsieh MH, Chang CC, Yang WC, Lin JJ, Chou FH, Faraone SV, Tsuang MT, Hwu HG.

    07/2/2008
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Stargazin involvement with bipolar disorder and response to lithium treatment.
    Silberberg G, Levit A, Collier D, St Clair D, Munro J, Kerwin RW, Tondo L, Floris G, Breen G, Navon R, Silberberg G, Levit A, Collier D, St Clair D, Munro J, Kerwin RW, Tondo L, Floris G, Breen G, Navon R.

    04/23/2008
    the Q/R site modulates the interaction of stargazin with the transmembrane domains of AMPA receptors via an allosteric mechanism and that this modulation leads to the observed differences in the electrophysiological properties of the receptor

    Stargazin interaction with alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors is critically dependent on the amino acid at the narrow constriction of the ion channel.
    Körber C, Werner M, Hoffmann J, Sager C, Tietze M, Schmid SM, Kott S, Hollmann M.

    01/21/2010
    Stargazin enhances trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors GluR1 and GluR2 by blocking endoplasmic reticulum retention.

    Different domains of the AMPA receptor direct stargazin-mediated trafficking and stargazin-mediated modulation of kinetics.
    Bedoukian MA, Weeks AM, Partin KM.

    01/21/2010
    These results suggest that stargazin (gamma-2) not only promotes AMPA receptor surface expression but also directly modulates AMPA receptor activity.

    A novel action of stargazin as an enhancer of AMPA receptor activity.
    Yamazaki M, Ohno-Shosaku T, Fukaya M, Kano M, Watanabe M, Sakimura K.

    01/21/2010
    examined distribution of the stargazin-like proteins gamma2, gamma3, and gamma4 in human CNS: gamma2 is expressed in cerebellum, cerebral cortex, hippocampus and thalamus, whereas gamma3 abounds in cerebral cortex & amygdala and gamma4 in basal ganglia

    Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.
    Moss FJ, Dolphin AC, Clare JJ., Free PMC Article

    01/21/2010
    AMPA receptors complexed with stargazin are significantly more responsive to synaptically released glutamate compared with AMPA receptors lacking stargazin.

    Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors.
    Priel A, Kolleker A, Ayalon G, Gillor M, Osten P, Stern-Bach Y., Free PMC Article

    01/21/2010
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