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    CDKN2A cyclin dependent kinase inhibitor 2A [ Homo sapiens (human) ]

    Gene ID: 1029, updated on 25-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Impact of CDKN2A gene expression on colon adenocarcinoma via biosignature analysis.

    Impact of CDKN2A gene expression on colon adenocarcinoma via biosignature analysis.
    Xu C.

    10/9/2024
    Relationship between p16/ki67 immunoscores and PAX1/ZNF582 methylation status in precancerous and cancerous cervical lesions in high-risk HPV-positive women.

    Relationship between p16/ki67 immunoscores and PAX1/ZNF582 methylation status in precancerous and cancerous cervical lesions in high-risk HPV-positive women.
    Luo H, Lian Y, Tao H, Zhao Y, Wang Z, Zhou J, Zhang Z, Jiang S., Free PMC Article

    09/29/2024
    T2-FLAIR mismatch sign, an imaging biomarker for CDKN2A-intact in non-enhancing astrocytoma, IDH-mutant.

    T2-FLAIR mismatch sign, an imaging biomarker for CDKN2A-intact in non-enhancing astrocytoma, IDH-mutant.
    Onishi S, Kojima M, Yamasaki F, Amatya VJ, Yonezawa U, Taguchi A, Ozono I, Go Y, Takeshima Y, Hiyama E, Horie N., Free PMC Article

    09/17/2024
    Prognostic Impact of CDKN2A Mutations Associated With Smoking and Drinking History in Japanese Digestive Cancers.

    Prognostic Impact of CDKN2A Mutations Associated With Smoking and Drinking History in Japanese Digestive Cancers.
    Fujita K, Hayashi M, Nakagawa N, Kurimoto K, Inokawa Y, Takami H, Nakanishi K, Umeda S, Shimizu D, Hattori N, Kanda M, Tanaka C, Nakayama G, Kodera Y.

    09/12/2024
    Cathepsin L induces cellular senescence by upregulating CUX1 and p16[INK4a].

    Cathepsin L induces cellular senescence by upregulating CUX1 and p16(INK4a).
    Wu Y, Jiang D, Liu Q, Yan S, Liu X, Wu T, Sun W, Li G., Free PMC Article

    08/30/2024
    A novel EZH2/NXPH4/CDKN2A axis is involved in regulating the proliferation and migration of non-small cell lung cancer cells.

    A novel EZH2/NXPH4/CDKN2A axis is involved in regulating the proliferation and migration of non-small cell lung cancer cells.
    Yang Z, Wei B, Qiao A, Yang P, Chen W, Zhen D, Qiu X.

    08/30/2024
    SATB1 and p16 Expression and Prognostic Value in Croatian Hodgkin Lymphoma Patients: A Unicentric Study.

    SATB1 and p16 Expression and Prognostic Value in Croatian Hodgkin Lymphoma Patients: A Unicentric Study.
    Vicelić Čutura L, Vujčić M, Galušić D, Blaslov V, Petrić M, Miljak A, Lozić M, Benzon B, Vukojević K, Bubić T, Kunac N, Zjačić Puljiz D, Delić Jukić IK, Križanac M, Lozić B., Free PMC Article

    08/29/2024
    The crosstalk role of CDKN2A between tumor progression and cuproptosis resistance in colorectal cancer.

    The crosstalk role of CDKN2A between tumor progression and cuproptosis resistance in colorectal cancer.
    Cheng X, Yang F, Li Y, Cao Y, Zhang M, Ji J, Bai Y, Li Q, Yu Q, Gao D., Free PMC Article

    07/30/2024
    Expression of p16 protein in breast cancer.

    Expression of p16 protein in breast cancer.
    Samman A, Hanbazazh M, Samargandy S, Al-Maghrabi J.

    07/15/2024
    Uterine Inflammatory Myofibroblastic Tumors: p16 as a Surrogate for CDKN2A Deletion and Predictor of Aggressive Behavior.

    Uterine Inflammatory Myofibroblastic Tumors: p16 as a Surrogate for CDKN2A Deletion and Predictor of Aggressive Behavior.
    Devins KM, Ordulu Z, Mendoza RP, Croce S, Haridas R, Wanjari P, Pinto A, Oliva E, Bennett JA.

    07/9/2024
    Concordance between CDKN2A homozygous deletion and MTAP immunohistochemical loss in fluoroedenite-induced pleural mesothelioma: An immunohistochemical and molecular study on a single-institution series.

    Concordance between CDKN2A homozygous deletion and MTAP immunohistochemical loss in fluoroedenite-induced pleural mesothelioma: An immunohistochemical and molecular study on a single-institution series.
    Broggi G, Massimino M, Failla M, Filetti V, Rapisarda V, Ledda C, Lombardo C, Loreto C, Vigneri P, Caltabiano R.

    06/28/2024
    iChIP-SILAC analysis identifies epigenetic regulators of CpG methylation of the p16[INK4A] gene.

    iChIP-SILAC analysis identifies epigenetic regulators of CpG methylation of the p16(INK4A) gene.
    Fujita T, Fujii H.

    06/25/2024
    Pan-cancer analysis of CDKN2A alterations identifies a subset of gastric cancer with a cold tumor immune microenvironment.

    Pan-cancer analysis of CDKN2A alterations identifies a subset of gastric cancer with a cold tumor immune microenvironment.
    Deng C, Li ZX, Xie CJ, Zhang QL, Hu BS, Wang MD, Mei J, Yang C, Zhong Z, Wang KW., Free PMC Article

    06/7/2024
    [Methylthioadenosine phosphorylase and p16 as surrogate diagnostic markers for CDKN2A homozygous deletion in brain tumors].

    [Methylthioadenosine phosphorylase and p16 as surrogate diagnostic markers for CDKN2A homozygous deletion in brain tumors].
    Wang SN, Wang W, Zhang XW, Zhang YQ, Xiong YL, Liu L, Teng LH.

    05/22/2024
    De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression.

    De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression.
    Tangudu NK, Buj R, Wang H, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Yang B, Chatoff A, Crispim CV, Sajjakulnukit P, Lyons MA, Cooper K, Hempel N, Lyssiotis CA, Chandran UR, Snyder NW, Aird KM., Free PMC Article

    05/16/2024
    Molecular monitoring by CDKN2A/p16INK4A and RB1 gene methylation in breast cancer.

    Molecular monitoring by CDKN2A/p16INK4A and RB1 gene methylation in breast cancer.
    Queiroz LF, Silva MSDME, Rosman FC, Rosas SLB, Souza HSP, Carvalho MDGDC., Free PMC Article

    05/13/2024
    LncRNA CAI2 Contributes to Poor Prognosis of Glioma through the PI3K-Akt Signaling Pathway.

    LncRNA CAI2 Contributes to Poor Prognosis of Glioma through the PI3K-Akt Signaling Pathway.
    Jiang Y, Zhang J, Yu S, Zheng L, Shen Y, Ju W, Lin L.

    04/29/2024
    Treatments, prognostic factors, and genetic heterogeneity in advanced cholangiocarcinoma: A multicenter real-world study.

    Treatments, prognostic factors, and genetic heterogeneity in advanced cholangiocarcinoma: A multicenter real-world study.
    Ottaiano A, Santorsola M, Diana A, Belli A, Lentini Graziano ML, Orefice J, Patrone R, Di Mauro A, Scognamiglio G, Tatangelo F, De Bellis M, Piccirillo M, Fiore F, Stilo S, Tarotto L, Correra M, Di Lorenzo S, Capuozzo M, Avallone A, Silvestro L, Bianco A, Granata V, Federico P, Montesarchio V, Daniele B, Izzo F, Nasti G., Free PMC Article

    04/24/2024
    High P16INK4A Expression, Keratinizing Features, and Surgical Margin-Free Status are Associated with Improved Survival in Patients with Oral Squamous Cell Carcinomas.

    High P16INK4A Expression, Keratinizing Features, and Surgical Margin-Free Status are Associated with Improved Survival in Patients with Oral Squamous Cell Carcinomas.
    Anwar SL, Dwianingsih EK, Lestari SP, Sugandhi W, Cahyono R, Pradana GD., Free PMC Article

    04/2/2024
    CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence in-situ hybridization.

    CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence in-situ hybridization.
    Ranade M, Epari S, Shetty O, Dhanavade S, Chavan S, Sahay A, Sahu A, Shetty P, Moiyadi A, Singh V, Dasgupta A, Chatterjee A, Kannan S, Gupta T.

    03/29/2024
    PR55alpha-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by gamma-irradiation.

    PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation.
    Palanivel C, Madduri LSV, Hein AL, Jenkins CB, Graff BT, Camero AL, Zhou S, Enke CA, Ouellette MM, Yan Y., Free PMC Article

    03/22/2024
    HPV related p16[INK4A] and HSV in benign and potentially malignant oral mucosa pathologies.

    HPV related p16(INK4A) and HSV in benign and potentially malignant oral mucosa pathologies.
    Duś-Ilnicka I, Hałoń A, Perra A, Radwan-Oczko M., Free PMC Article

    03/20/2024
    Evaluation of rs10811661 polymorphism in CDKN2A / B in colon and gastric cancer.

    Evaluation of rs10811661 polymorphism in CDKN2A / B in colon and gastric cancer.
    Beihaghi M, Sahebi R, Beihaghi MR, Nessiani RK, Yarasmi MR, Gholamalizadeh S, Shahabnavaie F, Shojaei M., Free PMC Article

    03/18/2024
    Assessment and clinicopathological correlation of p16 expression in cervical squamous cell carcinoma of Indian population: Diagnostic implications.

    Assessment and clinicopathological correlation of p16 expression in cervical squamous cell carcinoma of Indian population: Diagnostic implications.
    Paul A, Dutta P, Basu K.

    03/13/2024
    CDKN2A promoter methylation enhances self-renewal of glioblastoma stem cells and confers resistance to carmustine.

    CDKN2A promoter methylation enhances self-renewal of glioblastoma stem cells and confers resistance to carmustine.
    Wang J, Xi YF, Zhao Q, Guo JH, Zhang Z, Zhang MB, Chang J, Wu YQ, Su W., Free PMC Article

    03/6/2024
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