| Involvement of RAMP1/p38MAPK signaling pathway in osteoblast differentiation in response to mechanical stimulation: a preliminary study. | Involvement of RAMP1/p38MAPK signaling pathway in osteoblast differentiation in response to mechanical stimulation: a preliminary study.
Binlateh T, Leethanakul C, Thammanichanon P., Free PMC Article | 10/2/2024 |
| Peptide ligand interaction with maltose-binding protein tagged to the calcitonin gene-related peptide receptor: The inhibitory role of receptor N-glycosylation. | Peptide ligand interaction with maltose-binding protein tagged to the calcitonin gene-related peptide receptor: The inhibitory role of receptor N-glycosylation.
Lee S. | 04/16/2022 |
| Structure and dynamics of the CGRP receptor in apo and peptide-bound forms. | Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.
Josephs TM, Belousoff MJ, Liang YL, Piper SJ, Cao J, Garama DJ, Leach K, Gregory KJ, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM. | 05/1/2021 |
| in nestin/hRAMP1 transgenic mice, hypertension caused by Ang II or phenylephrine was greatly attenuated, and associated autonomic dysregulation and increased sympathetic vasomotor tone were diminished or abolished. | Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension.
Sabharwal R, Mason BN, Kuburas A, Abboud FM, Russo AF, Chapleau MW., Free PMC Article | 03/7/2020 |
| Based on the finding that an acylated chimeric ADM/ADM2 analog potently stimulates CLR/RAMP1 and 2 signaling, we hypothesized that the binding domain of this analog could have potent inhibitory activity on CLR/RAMP receptors. | Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.
Chang CL, Hsu SYT., Free PMC Article | 01/25/2020 |
| structure of the human CGRP receptor in complex with CGRP and the Gs-protein heterotrimer at 3.3 A global resolution, determined by Volta phase-plate cryo-electron microscopy | Cryo-EM structure of the active, G(s)-protein complexed, human CGRP receptor.
Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM., Free PMC Article | 03/23/2019 |
| T-A-T RAMP1 gene haplotype might have utility as a genetic marker for Essential Hypertension and that the RAMP1 gene may be associated with increased susceptibility to Essential Hypertension in a Japanese population. | Haplotype-based, case-control study of the receptor (calcitonin) activity-modifying protein (RAMP) 1 gene in essential hypertension.
Nakayama T, Nakazato T, Naruse H, Fu Z, Wang Z, Soma M, Hoshino T, Shimodaira M, Aoi N. | 02/24/2018 |
| Data suggest CGRP receptor (CGRPR) ECL2 (extracellular loop 2 domain) enables interaction with N-terminal residues of CGRP; this provides evidence for dual involvement of ECL2 in two-domain binding model of CGRP/CGRPR interaction; CGRPR is obligate heterodimer of CLR/RAMP1. (CGRP = calcitonin gene-related peptide; CLR = calcitonin receptor-like receptor; RAMP1 = receptor [calcitonin] activity modifying protein 1) | Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP(8-37)): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model.
Woolley MJ, Simms J, Uddin S, Poyner DR, Conner AC. | 08/12/2017 |
| Evidence that DNA methylation at RAMP1 gene promoter plays a role in migraine was described. | DNA methylation of RAMP1 gene in migraine: an exploratory analysis.
Wan D, Hou L, Zhang X, Han X, Chen M, Tang W, Liu R, Dong Z, Yu S., Free PMC Article | 05/21/2016 |
| RAMP1 rs7590387 has a role in the transformation of episodic migraine into medication overuse headache. | Association of RAMP1 rs7590387 with the risk of migraine transformation into medication overuse headache.
Cargnin S, Pautasso C, Viana M, Sances G, Mittino D, Cantello R, Tassorelli C, Nappi G, Terrazzino S. | 04/2/2016 |
| Data suggest that ligand binding of a G protein-coupled receptor (GPCR) may inform drug development targeting calcitonin receptor-like receptor (CLR):receptor activity-modifying proteins RAMP1/2 complexes. | Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Booe JM, Walker CS, Barwell J, Kuteyi G, Simms J, Jamaluddin MA, Warner ML, Bill RM, Harris PW, Brimble MA, Poyner DR, Hay DL, Pioszak AA., Free PMC Article | 09/26/2015 |
| A novel functional role for RAMP1 in regulation of CaSR signalling in addition to its known role in receptor trafficking, is reported. | Role of receptor activity modifying protein 1 in function of the calcium sensing receptor in the human TT thyroid carcinoma cell line.
Desai AJ, Roberts DJ, Richards GO, Skerry TM., Free PMC Article | 09/20/2014 |
| multiple NKX3.1 binding sites were found in the RAMP1 locus in human prostate cancer cells and in the normal mouse prostate. | RAMP1 is a direct NKX3.1 target gene up-regulated in prostate cancer that promotes tumorigenesis.
Logan M, Anderson PD, Saab ST, Hameed O, Abdulkadir SA., Free PMC Article | 03/15/2014 |
| RAMP1 overexpression enhances the promoting effect that exogenous CGRP has on osteogenic differentiation | The influence of RAMP1 overexpression on CGRP-induced osteogenic differentiation in MG-63 cells in vitro: an experimental study.
Zhao Z, Fu X, Zhang G, Li Y, Wu M, Tan Y. | 06/8/2013 |
| No significant association of the tested SNPs of the RAMP1 gene were found with migraine susceptibility. | Association study of the calcitonin gene-related polypeptide-alpha (CALCA) and the receptor activity modifying 1 (RAMP1) genes with migraine.
Sutherland HG, Buteri J, Menon S, Haupt LM, Macgregor EA, Lea RA, Griffiths LR. | 03/23/2013 |
| CLR and RAMP1 co-localize in the enteric nervous system of human stomach, ileum, and colon, and are in close proximity to their ligands CGRP and IMD | Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.
Cottrell GS, Alemi F, Kirkland JG, Grady EF, Corvera CU, Bhargava A., Free PMC Article | 11/24/2012 |
| The present finding demonstrated that RAMP1 immunoreactivity was localized in many neurons and phenopalatine ganglion. | Calcitonin gene-related peptide and its receptor components in the human sphenopalatine ganglion -- interaction with the sensory system.
Csati A, Tajti J, Tuka B, Edvinsson L, Warfvinge K. | 11/17/2012 |
| lower expression in bronchial biopsies from subjects with asthma | Expression of functional receptor activity modifying protein 1 by airway epithelial cells with dysregulation in asthma.
Bonner K, Kariyawasam HH, Ali FR, Clark P, Kay AB. | 04/9/2011 |
| The T-A-C haplotype is a genetic marker for cerebral infarction, and RAMP1 is associated with increased susceptibility to cerebral infarction. | Haplotype-based case-control study of receptor (calcitonin) activity-modifying protein-1 gene in cerebral infarction.
Nakazato T, Nakayama T, Naganuma T, Sato N, Fu Z, Wang Z, Soma M, Sugama K, Hinohara S, Doba N, Nakazato T, Nakayama T, Naganuma T, Sato N, Fu Z, Wang Z, Soma M, Sugama K, Hinohara S, Doba N. | 08/9/2010 |
| These data for the first time pinpoint a specific RAMP1 residue important for both antagonist and agonist potency and are consistent with the N-terminal domain of RAMP1 forming the binding pocket interface with calcitonin receptor-like receptor. | Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding.
Moore EL, Gingell JJ, Kane SA, Hay DL, Salvatore CA. | 05/3/2010 |
| RAMP1 overexpression attenuates Ang-II-induced hypertension and induces a protective change in cardiovascular autonomic regulation | Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension.
Sabharwal R, Zhang Z, Lu Y, Abboud FM, Russo AF, Chapleau MW., Free PMC Article | 03/22/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Haplotype-based case-control study of receptor (calcitonin) activity-modifying protein-1 gene in cerebral infarction.
Nakazato T, Nakayama T, Naganuma T, Sato N, Fu Z, Wang Z, Soma M, Sugama K, Hinohara S, Doba N, Nakazato T, Nakayama T, Naganuma T, Sato N, Fu Z, Wang Z, Soma M, Sugama K, Hinohara S, Doba N. | 09/16/2009 |
| the crystal structure of the extracellular domain of human RAMP1 at 2.4 A resolution was determined. | Crystal structure of the human receptor activity-modifying protein 1 extracellular domain.
Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M, Shindo T, Yokoyama S., Free PMC Article | 01/21/2010 |
| Data found that expressions of RAMP1, RAMP2 and RAMP3 mRNAs increased with the worsening of heart function, but the expressions of RAMP1 and RAMP2 mRNA decreased at level IV of heart failure. | [Increased atria expression of receptor activity-modifying proteins in heart failure patients].
Wang YF, Zhang J, Li J, Lan LQ, Yang ZM, Wang SR. | 01/21/2010 |
| Identification of RAMP1 residues important for calcitonin gene-related peptide are reported. | Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function.
Qi T, Christopoulos G, Bailey RJ, Christopoulos A, Sexton PM, Hay DL. | 01/21/2010 |