| PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation. | PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation.
Yoshioka Y, Huang Y, Jin X, Ngo KX, Kumaki T, Jin M, Toyoda S, Takayama S, Inotsume M, Fujita K, Homma H, Ando T, Tanaka H, Okazawa H., Free PMC Article | 09/24/2024 |
| REGgamma Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis. | REGγ Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis.
Zhu X, Li Y, Tian X, Jing Y, Wang Z, Yue L, Li J, Wu L, Zhou X, Yu Z, Zhang Y, Guan F, Yang M, Zhang B. | 08/7/2024 |
| Comprehensive analysis of PSME3: from pan-cancer analysis to experimental validation. | Comprehensive analysis of PSME3: from pan-cancer analysis to experimental validation.
Dong C, Guo Y, Yang Y, Ge X., Free PMC Article | 02/6/2024 |
| LncRNA PSMA3-AS1 activates the progression of triple-negative breast cancer cells by blocking miR-186-5p-mediated PSME3 inhibition. | LncRNA PSMA3-AS1 activates the progression of triple-negative breast cancer cells by blocking miR-186-5p-mediated PSME3 inhibition.
Peng M, Yuan H. | 02/1/2024 |
| MicroRNA-130a-3p impedes the progression of papillary thyroid carcinoma through downregulation of KPNB1 by targeting PSME3. | MicroRNA-130a-3p impedes the progression of papillary thyroid carcinoma through downregulation of KPNB1 by targeting PSME3.
Wang Y, Xu J, Zhu X, Kuang H. | 08/30/2023 |
| circFANCA accelerates the malignant process of OSCC by modulating miR-34a/PA28gamma signaling. | circFANCA accelerates the malignant process of OSCC by modulating miR-34a/PA28γ signaling.
Ren Y, Pan K, Wang Y, Zhang S, Wang Y, Zhou X, Dan H, Chen Q, Ji N, Li J. | 06/2/2023 |
| Proteasomal activator 28 gamma stabilizes hepatitis B virus X protein by competitively inhibiting the Siah-1-mediated proteasomal degradation. | Proteasomal activator 28 gamma stabilizes hepatitis B virus X protein by competitively inhibiting the Siah-1-mediated proteasomal degradation.
Han J, Kim H, Jeong H, Yoon H, Jang KL. | 01/29/2022 |
| PA28gamma-20S proteasome is a proteolytic complex committed to degrade unfolded proteins. | PA28γ-20S proteasome is a proteolytic complex committed to degrade unfolded proteins.
Frayssinhes JA, Cerruti F, Laulin J, Cattaneo A, Bachi A, Apcher S, Coux O, Cascio P., Free PMC Article | 01/22/2022 |
| The proteasome activator REGgamma accelerates cardiac hypertrophy by declining PP2Acalpha-SOD2 pathway. | The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα-SOD2 pathway.
Xie Y, Gao Y, Gao R, Yang W, Dong Z, Moses RE, Sun A, Li X, Ge J., Free PMC Article | 11/13/2021 |
| REGgamma regulates hair cycle by activating Lgr5 positive hair follicle stem cells. | REGγ regulates hair cycle by activating Lgr5 positive hair follicle stem cells.
Gao X, Wang Q, Yuan L, Jiao C, Yu Y, Wang X, Xu P, Ma Y, Wu Y, Wu Z, Li L, Xiao J, Dang Y. | 07/31/2021 |
| Reciprocal REGgamma-mTORC1 regulation promotes glycolytic metabolism in hepatocellular carcinoma. | Reciprocal REGγ-mTORC1 regulation promotes glycolytic metabolism in hepatocellular carcinoma.
Yao L, Xuan Y, Zhang H, Yang B, Ma X, Wang T, Meng T, Sun W, Wei H, Ma X, Moses R, Xiao J, Zhang P, Ge C, Li J, Li L, Li X, Li J, Zhang B. | 07/31/2021 |
| PA28gamma: New Insights on an Ancient Proteasome Activator. | PA28γ: New Insights on an Ancient Proteasome Activator.
Cascio P., Free PMC Article | 07/3/2021 |
| REGgamma ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-beta pathway. | REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway.
Jiao C, Li L, Zhang P, Zhang L, Li K, Fang R, Yuan L, Shi K, Pan L, Guo Q, Gao X, Chen G, Xu S, Wang Q, Zuo D, Wu W, Qiao S, Wang X, Moses R, Xiao J, Li L, Dang Y, Li X., Free PMC Article | 07/3/2021 |
| Hepatitis B virus X protein stimulates cell growth by downregulating p16 levels via PA28gamma-mediated proteasomal degradation. | Hepatitis B virus X protein stimulates cell growth by downregulating p16 levels via PA28γ-mediated proteasomal degradation.
Cha S, Jang KL. | 03/20/2021 |
| Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks. | Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks.
Lesne J, Locard-Paulet M, Parra J, Zivković D, Menneteau T, Bousquet MP, Burlet-Schiltz O, Marcoux J., Free PMC Article | 12/19/2020 |
| REGgamma potentiates TGF-beta/Smad signal dependent epithelial-mesenchymal transition in thyroid cancer cells. | REGγ potentiates TGF-β/Smad signal dependent epithelial-mesenchymal transition in thyroid cancer cells.
Bhatti MZ, Pan L, Wang T, Shi P, Li L. | 09/12/2020 |
| Expression of REGgamma in atherosclerotic plaques and promotes endothelial cells apoptosis via the cyclophilin A pathway indicates functional implications in atherogenesis. | Expression of REGγ in atherosclerotic plaques and promotes endothelial cells apoptosis via the cyclophilin A pathway indicates functional implications in atherogenesis.
Xie Y, Li X, Ge J., Free PMC Article | 08/29/2020 |
| PSME3 was upregulated in the colorectal cancer.PSME3 may promote proliferation, invasive and migratory potential of the colorectal cancer. | Silencing PSME3 induces colorectal cancer radiosensitivity by downregulating the expression of cyclin B1 and CKD1.
Song W, Guo C, Chen J, Duan S, Hu Y, Zou Y, Chi H, Geng J, Zhou J., Free PMC Article | 06/20/2020 |
| In conclusion, the ability of hepatitis B virus X protein to upregulate human PA28gamma levels via p53 activation, in a Ser-101-dependent pathway, is critical for the stimulation of hepatitis B virus replication. | HBx natural variants containing Ser-101 instead of Pro-101 evade ubiquitin-dependent proteasomal degradation by activating proteasomal activator 28 gamma expression.
Jeong H, Cha S, Jang KL. | 06/13/2020 |
| U2AF1 was significantly positively associated with PA28gamma in oral squamous cell carcinoma | The significance of PA28γ and U2AF1 in oral mucosal carcinogenesis.
Yin F, Wang J, Zhao K, Xin C, Shi Y, Zeng X, Xu H, Li J, Chen Q. | 01/25/2020 |
| REGgamma could be a master regulator during colorectal cancer development to promote YAP signaling and reinforce cross-talks between inflammation and growth pathways, and REGgamma might be a new marker for prognosis of colorectal cancer patients. | REGγ Controls Hippo Signaling and Reciprocal NF-κB-YAP Regulation to Promote Colon Cancer.
Wang Q, Gao X, Yu T, Yuan L, Dai J, Wang W, Chen G, Jiao C, Zhou W, Huang Q, Cui L, Zhang P, Moses RE, Yang J, Chen F, Fu J, Xiao J, Li L, Dang Y, Li X. | 12/21/2019 |
| casein kinase 1epsilon (CK1epsilon) was identified as a novel target of REGgamma and knockdown of CK1epsilon effectively abolished the effect of REGgamma depletion on renal cell carcinoma cells growth. | REGγ deficiency suppresses tumor progression via stabilizing CK1ε in renal cell carcinoma.
Chen S, Wang Q, Wang L, Chen H, Gao X, Gong D, Ma J, Kubra S, Yao X, Li X, Li L, Zhai W, Zheng J., Free PMC Article | 12/14/2019 |
| HCV core fragment (Core71) binds to the 20S proteasome and its activator PA28gamma. The N-terminal 1-71 fragment of Hepatitis C virus (HCV) core protein (Core71) enhances the PA28gamma-20S complex formation with reduced proteolytic activity. Fragmented HCV core can cause pathogenic dysfunction of proteasomes in the nucleus. | N-terminal HCV core protein fragment decreases 20S proteasome activity in the presence of PA28γ.
Zheng Y, Shimamoto S, Maruno T, Kobayashi Y, Matsuura Y, Kawahara K, Yoshida T, Ohkubo T. | 11/2/2019 |
| Study found that PA28gamma enhanced the ability of oral squamous cell carcinoma (OSCC) cells to promote the migration, invasion, and tube formation of HUVECs and promoted tumor-induced angiogenesis in xenograft mice models in vivo. Expression and secretion of IL-6 and CCL2 were dependent on PA28gamma expression. In addition, IL-6, CCL2 and PA28gamma expressions were correlated in a clinical OSCC cohort. | PA28γ acts as a dual regulator of IL-6 and CCL2 and contributes to tumor angiogenesis in oral squamous cell carcinoma.
Liu S, Liu D, Zeng X, Wang J, Liu J, Cheng J, Lei K, Bai H, Ji N, Zhou M, Jiang L, Dan H, Li J, Chen Q. | 08/10/2019 |
| HBx levels are upregulated via a positive feedback loop involving p53 and PA28gamma to stimulate hepatitis B virus propagation. | Hepatitis B virus X protein activates proteasomal activator 28 gamma expression via upregulation of p53 levels to stimulate virus replication.
Yeom S, Jeong H, Kim SS, Jang KL. | 03/30/2019 |