| Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations. | Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations.
Nan H, Kim YJ, Chu M, Li D, Li J, Jiang D, Wu Y, Ohtsuka T, Wu L., Free PMC Article | 06/14/2024 |
| Optineurin provides a mitophagy contact site for TBK1 activation. | Optineurin provides a mitophagy contact site for TBK1 activation.
Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Endo R, Kinefuchi H, Sugihara A, Fujino T, Watanabe A, Tanaka K, Hayashi G, Murakami H, Matsuda N., Free PMC Article | 03/7/2024 |
| Roles and mechanisms of optineurin in bone metabolism. | Roles and mechanisms of optineurin in bone metabolism.
Jin J, Huang R, Chang Y, Yi X. | 03/6/2024 |
| [Optineurin and mitochondrial dysfunction in neurodegeneration]. | [Optineurin and mitochondrial dysfunction in neurodegeneration].
D'Urso B, Weil R, Génin P. | 02/28/2024 |
| Optineurin in patients with Amyotrophic Lateral Sclerosis associated to atypical Parkinsonism in Tunisian population. | Optineurin in patients with Amyotrophic Lateral Sclerosis associated to atypical Parkinsonism in Tunisian population.
Kacem I, Sghaier I, Peverelli S, Abida Y, Ben Brahim H, Ratti A, Nasri A, Ticozzi N, Silani V, Gouider R. | 02/2/2024 |
| Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation. | Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation.
Mishra D, Narain P, Dave U, Gomes J. | 12/6/2023 |
| Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia. | Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia.
Meyer LM, Koschade SE, Vischedyk JB, Thoelken M, Gubas A, Wegner M, Basoglu M, Knapp S, Kaulich M, Eimer S, Shaid S, Brandts CH., Free PMC Article | 10/16/2023 |
| Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection. | Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection.
Fukushi M, Ohsawa R, Okinaka Y, Oikawa D, Kiyono T, Moriwaki M, Irie T, Oda K, Kamei Y, Tokunaga F, Sotomaru Y, Maruyama H, Kawakami H, Sakaguchi T., Free PMC Article | 06/30/2023 |
| A glaucoma-associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor alpha. | A glaucoma-associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor α.
Sayyad Z, Kaveti S, Bhattacharjee D, Vedagiri D, Jain N, Swarup G. | 06/23/2023 |
| Differential optineurin expression controls TGFbeta signaling and is a key determinant for metastasis of triple negative breast cancer. | Differential optineurin expression controls TGFβ signaling and is a key determinant for metastasis of triple negative breast cancer.
Liu S, van Dinther M, Hagenaars SC, Gu Y, Kuipers TB, Mei H, Gomez-Puerto MC, Mesker WE, Ten Dijke P. | 04/19/2023 |
| Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants. | Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants.
Moharir SC, Sirohi K, Swarup G. | 02/10/2023 |
| SUMOylation of optineurin is critical for inhibiting interferon beta production. | SUMOylation of optineurin is critical for inhibiting interferon β production.
Hu X, Wu H. | 08/27/2022 |
| Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. | Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN.
Ke PY, Chang CW, Hsiao YC., Free PMC Article | 07/23/2022 |
| Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma. | Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma.
Liu X, Wang Q, Shao Z, Zhang S, Hou M, Jiang M, Du M, Li J, Yuan H. | 03/5/2022 |
| Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma. | Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma.
Sayyad Z, Vishwakarma S, Dave TV, Naik MN, Radha V, Kaur I, Swarup G. | 01/22/2022 |
| Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection. | Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection.
Patil CD, Suryawanshi R, Ames J, Koganti R, Agelidis A, Kapoor D, Yadavalli T, Koujah L, Tseng HC, Shukla D., Free PMC Article | 01/15/2022 |
| A recessive S174X mutation in Optineurin causes amyotrophic lateral sclerosis through a loss of function via allele-specific nonsense-mediated decay. | A recessive S174X mutation in Optineurin causes amyotrophic lateral sclerosis through a loss of function via allele-specific nonsense-mediated decay.
Gotkine M, de Majo M, Wong CH, Topp SD, Michaelson-Cohen R, Epsztejn-Litman S, Eiges R, Y YL, Kanaan M, Shaked HM, Alahmady N, Vance C, Newhouse SJ, Breen G, Nishimura AL, Shaw CE, Smith BN. | 01/1/2022 |
| Optineurin defects cause TDP43-pathology with autophagic vacuolar formation. | Optineurin defects cause TDP43-pathology with autophagic vacuolar formation.
Kurashige T, Kuramochi M, Ohsawa R, Yamashita Y, Shioi G, Morino H, Kamada M, Ayaki T, Ito H, Sotomaru Y, Maruyama H, Kawakami H. | 12/11/2021 |
| Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling. | Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling.
Wang J, Wang J, Hong W, Zhang L, Song L, Shi Q, Shao Y, Hao G, Fang C, Qiu Y, Yang L, Yang Z, Wang J, Cao J, Yang B, He Q, Weng Q., Free PMC Article | 12/4/2021 |
| iTRAQ-Based Quantitative Proteomics Indicated Nrf2/OPTN-Mediated Mitophagy Inhibits NLRP3 Inflammasome Activation after Intracerebral Hemorrhage. | iTRAQ-Based Quantitative Proteomics Indicated Nrf2/OPTN-Mediated Mitophagy Inhibits NLRP3 Inflammasome Activation after Intracerebral Hemorrhage.
Cheng Y, Liu M, Tang H, Chen B, Yang G, Zhao W, Cai Y, Shang H., Free PMC Article | 09/11/2021 |
| Four novel optineurin mutations in patients with sporadic amyotrophic lateral sclerosis in Mainland China. | Four novel optineurin mutations in patients with sporadic amyotrophic lateral sclerosis in Mainland China.
Yang L, Cheng Y, Jia X, Liu X, Li X, Zhang K, Shen D, Liu M, Guan Y, Liu Q, Cui L, Li X. | 09/4/2021 |
| Conformational stabilization of optineurin by the dynamic interaction of linear polyubiquitin. | Conformational stabilization of optineurin by the dynamic interaction of linear polyubiquitin.
Kitamura A, Numazawa R, Kinjo M. | 08/28/2021 |
| A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress. | A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress.
Medchalmi S, Tare P, Sayyad Z, Swarup G. | 08/28/2021 |
| OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion. | OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion.
O'Loughlin T, Kruppa AJ, Ribeiro ALR, Edgar JR, Ghannam A, Smith AM, Buss F., Free PMC Article | 08/28/2021 |
| Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids. | Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.
VanderWall KB, Huang KC, Pan Y, Lavekar SS, Fligor CM, Allsop AR, Lentsch KA, Dang P, Zhang C, Tseng HC, Cummins TR, Meyer JS., Free PMC Article | 06/5/2021 |