| Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics. | Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics.
Peng Y, Zhao T, Rong S, Yang S, Teng W, Xie Y, Wang Y., Free PMC Article | 10/25/2024 |
| The majority of mutations responsible for autosomatic dominant optic atrophy are localized in OPA1 gene. Second locus is linked to 18q12.2-q12.3 (OPA4) and a third locus on 22q12.1-q13.1 (OPA5). | [Genetic basis of hereditary optic atrophies].
Wawrocka A, Krawczyński MR. | 09/22/2024 |
| Multifaceted role of dynamin-related protein 1 in cardiovascular disease: From mitochondrial fission to therapeutic interventions. | Multifaceted role of dynamin-related protein 1 in cardiovascular disease: From mitochondrial fission to therapeutic interventions.
Kaur S, Khullar N, Navik U, Bali A, Bhatti GK, Bhatti JS. | 09/20/2024 |
| Drp1: Focus on Diseases Triggered by the Mitochondrial Pathway. | Drp1: Focus on Diseases Triggered by the Mitochondrial Pathway.
Sun F, Fang M, Zhang H, Song Q, Li S, Li Y, Jiang S, Yang L. | 08/26/2024 |
| Serine 39 in the GTP-binding domain of Drp1 is involved in shaping mitochondrial morphology. | Serine 39 in the GTP-binding domain of Drp1 is involved in shaping mitochondrial morphology.
Ghani M, Szabó B, Alkhatibe M, Amsalu H, Zohar P, Janka EA, Mótyán JA, Tar K., Free PMC Article | 07/23/2024 |
| MCU inhibition protects against intestinal ischemia-reperfusion by inhibiting Drp1-dependent mitochondrial fission. | MCU inhibition protects against intestinal ischemia‒reperfusion by inhibiting Drp1-dependent mitochondrial fission.
Kadier T, Zhang YG, Jing YX, Weng ZY, Liao SS, Luo J, Ding K, Cao C, Chen R, Meng QT. | 06/27/2024 |
| MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1. | MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1.
Chen Y, Li S, Guan B, Yan X, Huang C, Du Y, Yang F, Zhang N, Li Y, Lu J, Wang J, Zhang J, Chen Z, Chen C, Kong X., Free PMC Article | 06/5/2024 |
| GTPBP8 modulates mitochondrial fission through a Drp1-dependent process. | GTPBP8 modulates mitochondrial fission through a Drp1-dependent process.
He X, Wang L, Tsang HY, Liu X, Yang X, Pu S, Guo Z, Yang C, Wu Q, Zhou Z, Cen X, Zhao H., Free PMC Article | 05/10/2024 |
| Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission. | Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission.
Yan J, Wang X, Fan Z, Xu Y, Zhang Y, Liu Y, Guo L, Liu D. | 05/7/2024 |
| Intertwined relationship of dynamin-related protein 1, mitochondrial metabolism and circadian rhythm. | Intertwined relationship of dynamin-related protein 1, mitochondrial metabolism and circadian rhythm.
Latha Laxmi IP, Job AT, Manickam V, Tamizhselvi R. | 04/10/2024 |
| A partial Drp1 knockout improves autophagy flux independent of mitochondrial function. | A partial Drp1 knockout improves autophagy flux independent of mitochondrial function.
Fan RZ, Sportelli C, Lai Y, Salehe SS, Pinnell JR, Brown HJ, Richardson JR, Luo S, Tieu K., Free PMC Article | 03/22/2024 |
| Enhanced T cell immune activity mediated by Drp1 promotes the efficacy of PD-1 inhibitors in treating lung cancer. | Enhanced T cell immune activity mediated by Drp1 promotes the efficacy of PD-1 inhibitors in treating lung cancer.
Ma J, Song J, Yi X, Zhang S, Sun L, Huang L, Han C., Free PMC Article | 02/28/2024 |
| Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin. | Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin.
Liu A, Hatch AL, Higgs HN., Free PMC Article | 01/16/2024 |
| A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission. | A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission.
Ihenacho UK, Toro R, Mansour RH, Hill RB., Free PMC Article | 11/30/2023 |
| Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration. | Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Ke W, Wang B, Liao Z, Song Y, Li G, Ma L, Wang K, Li S, Hua W, Yang C., Free PMC Article | 11/2/2023 |
| YY2-DRP1 Axis Regulates Mitochondrial Fission and Determines Cancer Stem Cell Asymmetric Division. | YY2-DRP1 Axis Regulates Mitochondrial Fission and Determines Cancer Stem Cell Asymmetric Division.
Wei M, Nurjanah U, Li J, Luo X, Hosea R, Li Y, Zeng J, Duan W, Song G, Miyagishi M, Kasim V, Wu S., Free PMC Article | 08/22/2023 |
| Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease. | Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease.
Bhatti JS, Kaur S, Mishra J, Dibbanti H, Singh A, Reddy AP, Bhatti GK, Reddy PH. | 08/9/2023 |
| Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary hypertension. | Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary hypertension.
Liu Y, Luo Y, Shi X, Lu Y, Li H, Fu G, Li X, Shan L. | 08/9/2023 |
| The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases. | The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases.
Colpman P, Dasgupta A, Archer SL., Free PMC Article | 08/2/2023 |
| Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery. | Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery.
Bauer BL, Rochon K, Liu JC, Ramachandran R, Mears JA., Free PMC Article | 06/8/2023 |
| AKAP1 Regulates Mitochondrial Dynamics during the Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing. | AKAP1 Regulates Mitochondrial Dynamics during the Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing.
Xiang H, Xu H, Tan B, Yi Q, Zhang X, Wang R, Chen T, Xie Q, Tian J, Zhu J., Free PMC Article | 06/7/2023 |
| Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma. | Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.
Zeng Z, You M, Fan C, Rong R, Li H, Xia X., Free PMC Article | 05/28/2023 |
| Mitochondrial impairment and downregulation of Drp1 phosphorylation underlie the antiproliferative and proapoptotic effects of alantolactone on oral squamous cell carcinoma cells. | Mitochondrial impairment and downregulation of Drp1 phosphorylation underlie the antiproliferative and proapoptotic effects of alantolactone on oral squamous cell carcinoma cells.
Zhang Y, Yang B, Tu C, Ping Y, Chen S, Wu T, Zhao Z, Mao Y, Yang Z, Cao Z, Li J, Huang K, Ding X, Wu G, Zou P, Deng Z, Sun X., Free PMC Article | 05/22/2023 |
| An integrated analysis of Dynamin 1 Like: A new potential prognostic indicator in hepatocellular carcinoma. | An integrated analysis of Dynamin 1 Like: A new potential prognostic indicator in hepatocellular carcinoma.
Zhang S, Gong H, Xie H, Huangfu Z, Tang Y, Xiao M, Li M, Li Q, Wang Y. | 05/15/2023 |
| Genetic defects in peroxisome morphogenesis (Pex11beta, dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid-phospholipid metabolism. | Genetic defects in peroxisome morphogenesis (Pex11β, dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid-phospholipid metabolism.
Abe Y, Wanders RJA, Waterham HR, Mandel H, Falik-Zaccai TC, Ishihara N, Fujiki Y. | 03/20/2023 |