4X7O: Co-crystal Structure of PERK bound to 1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone inhibitor

PDB ID: 4X7ODownload
MMDB ID: 126541
PDB Deposition Date: 2014/12/9
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.65  Å
Source Organism:
Similar Structures:
Biological Unit for 4X7O: monomeric; determined by author and by software (PISA)
Molecular Components in 4X7O
Label Count Molecule
Protein (1 molecule)
1
Eukaryotic Translation Initiation Factor 2-alpha Kinase 3,eukaryotic Translation Initiation Factor 2-alpha Kinase 3
(Gene symbol: EIF2AK3)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303