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Crystal structure of the KA1 domain from human Chk1[TRANSFERASE]
View in iCn3D Similar StructuresPubMedProteinsPubChem Compound
Multi-parameter lead optimization to give an oral CHK1 inhibitor clinical candidate: (R)-5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)[T...
View in iCn3D Similar StructuresPubMedProteinsConserved DomainsPubChem Compound
Identification of Novel, in vivo Active Chk1 Inhibitors Utilizing Structure Guided Drug Design[TRANSFERASE]
CHK1 kinase domain with diazacarbazole compound 19[TRANSFERASE/TRANSFERASE INHIBITOR]
CHK1 kinase domain with diazacarbazole compound 7: 3-(2-hydroxyphenyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile[TRANSFERASE/TRANSFERASE INHIBITOR]
CHK1 kinase domain with diazacarbazole compound 8: N-[3-(6-cyano-9H-pyrrolo[2,3-b:5,4-c']dipyridin-3-yl)phenyl]acetamide[TRANSFERASE/TRANSFERASE INHIBITOR]
CHK1 kinase domain in complex with diazacarbazole GNE-783[TRANSFERASE/TRANSFERASE INHIBITOR]
CHK1 kinase domain in complex with diazacarbazole compound 14[Transferase/Transferase Inhibitor]
CHK1 kinase domain in complex with aminopyrazine compound 13[Transferase/Transferase Inhibitor]
CHK1 kinase domain in complex with diarylpyrazine compound 1[Transferase/Transferase Inhibitor]
X-RAY Crystal structure of compound 22a (R)-2-(4-chlorophenyl)-8-(piperidin-3-ylamino)imidazo[1,2-c]pyrimidine-5-carboxamide bound to human chk1 kinase domain[TRANSFERASE/TRANSFERASE INHIBITOR]
X-RAY Crystal structure of compound 40 bound to human chk1 kinase domain[TRANSFERASE/TRANSFERASE INHIBITOR]
X-RAY Crystal structure of compound 39 bound to human chk1 kinase domain[TRANSFERASE/TRANSFERASE INHIBITOR]
Crystal Structure of the CHK1[TRANSFERASE/TRANSFERASE inhibitor]
View in iCn3D Similar StructuresProteinsConserved DomainsPubChem Compound
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