GSM4306632: THP-1 3hr 25nM INCB059872 A; Homo sapiens; RNA-Seq - SRA

SRX7708137: GSM4306632: THP-1 3hr 25nM INCB059872 A; Homo sapiens; RNA-Seq
1 ILLUMINA (Illumina HiSeq 3000) run: 38.1M spots, 1.9G bases, 620.8Mb downloads

Submitted by: NCBI (GEO)

Study: RNA-seq of MV-4-11 or THP-1 cells treated with LSD1 inhibitor INCB059872

PRJNA606049 • SRP248224 • All experiments • All runs

show Abstracthide Abstract

INCB059872 is a selective irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1) that is in phase 1 clinical trials in hematopoietic malignancies. LSD1 inhibition can induce differentiation of acute myeloid leukemia (AML), and here we have used RNA-seq to measure the transcriptional changes caused by INCB059872 in two AML cell lines. Overall design: Cells were treated (in duplicate) for 3hr or 24hr with INCB059872 before extracting RNA for polyA-enriched RNA-seq.

Sample: THP-1 3hr 25nM INCB059872 A

SAMN14083822 • SRS6131829 • All experiments • All runs

Organism: Homo sapiens

Library:

Instrument: Illumina HiSeq 3000

Strategy: RNA-Seq

Source: TRANSCRIPTOMIC

Selection: cDNA

Layout: SINGLE

Construction protocol: RNA was harvested using TRIzol reagent. Libraries were prepared from polyA-enriched RNA by standard Illumina protocols.

Experiment attributes:

GEO Accession: GSM4306632

Links:

NCBI link: NCBI Entrez (gds)

Runs: 1 run, 38.1M spots, 1.9G bases, 620.8Mb

Run	# of Spots	# of Bases	Size	Published
SRR11067856	38,115,697	1.9G	620.8Mb	2020-05-28

ID:: 10076845

SRA

Sequence Read Archive

Result Filters

Send to:

Supplemental Content

Related information

Search details

Recent activity