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SRX3051314: GSM2723929: 70528835N normal kidney RNA-seq; Homo sapiens; RNA-Seq
1 ILLUMINA (Illumina HiSeq 2000) run: 125.2M spots, 18.5G bases, 10.7Gb downloads

Submitted by: NCBI (GEO)
Study: Transcriptomics profiles of patient-matched normal kidney and ccRCC pairs
show Abstracthide Abstract
VHL loss is the most common genetic alteration event in ccRCC, but its effect on epigenetic landscape has not been elucidated previously. We describe the genome-wide cis-regulatory landscapes of VHL-deficient ccRCC tumors by comparing the epigenetic changes in terms of histone modifications (H3K27ac, H3K4me1, H3K4me3) with the transcriptomics profiles in 10 pairs of normal kidney and ccRCC tissues. Overall design: RNA-seq profiles of 10 patient-matched normal kidney and ccRCC pairs
Sample: 70528835N normal kidney RNA-seq
SAMN07429598 • SRS2397867 • All experiments • All runs
Organism: Homo sapiens
Library:
Instrument: Illumina HiSeq 2000
Strategy: RNA-Seq
Source: TRANSCRIPTOMIC
Selection: cDNA
Layout: PAIRED
Construction protocol: Total RNA was extracted using the Qiagen RNeasy Mini kit. RNAseq libraries were prepared using Illumina Tru-Seq RNA Sample Preparation v2 protocol, according to the manufacturer’s instructions. Briefly, poly-A RNAs were recovered from 1 µg of input total RNA using poly-T oligo conjugated magnetic beads. The recovered poly-A RNA was chemically fragmented and converted to SuperScript II and random primers. The second strand was synthesized using the Second Strand Master Mix. Libraries were validated with an Agilent Bioanalyzer (Agilent Technologies, Palo Alto, CA), diluted to 11 pM and applied to an Illumina flow cell using the Illumina Cluster Station.
Experiment attributes:
GEO Accession: GSM2723929
Links:
Runs: 1 run, 125.2M spots, 18.5G bases, 10.7Gb
Run# of Spots# of BasesSizePublished
SRR5885329125,225,64118.5G10.7Gb2017-08-22

ID:
4330733

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