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SRX23701635: RNA-Seq of Gallus Gallus: Embryo
1 ILLUMINA (NextSeq 2000) run: 33.9M spots, 2.7G bases, 818.8Mb downloads

Design: NEBNext Ultra II Directional RNA Library Prep Kit for Illumina
Submitted by: Uppsala University
Study: A male-essential microRNA is key for avian sex chromosome dosage compensation
show Abstracthide Abstract
In birds, females have two different sex chromosomes (ZW) and males have two identical ones (ZZ). As birds evolved, the W chromosome lost many genes. It's been unclear how birds adjusted to this loss in females. We studied a Z-linked microRNA (miR-2954) highly expressed in males and thought to help balance gene expression. When we knocked out miR-2954 in chickens, male embryos died, because dosage-sensitive Z-linked genes were over-expressed in males. Our research shows that birds have developed a unique mechanism to balance gene expression between the sexes, with a miRNA crucial for male survival.
Sample: 330_whole
SAMN40036845 • SRS20531603 • All experiments • All runs
Organism: Gallus gallus
Library:
Name: 330_whole
Instrument: NextSeq 2000
Strategy: RNA-Seq
Source: GENOMIC
Selection: PolyA
Layout: SINGLE
Runs: 1 run, 33.9M spots, 2.7G bases, 818.8Mb
Run# of Spots# of BasesSizePublished
SRR2805187033,919,2272.7G818.8Mb2024-03-08

ID:
31986259

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