SRA

The first aim of the study was to identify the genes regulated by the estrogen receptor alpha (ERa) in the normal mouse prostate, with and without the co-activation of the androgen receptor. The second objective was to decipher the changes in the estrogen and androgen responses in a tumoral context from prostate cancer-developping mice. Overall design: Sixteen normal prostate and 14 prostate cancer from mice have been collected, and treated with either Vehicle (control), 17ß-Estradiol, Testosterone or a combination of both 17ß-Estradiol and Testosterone. There were at least three replicates per condition, and samples were sequenced using Illumina NovaSeq 6000.