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SRX17583267: GSM6585356: 9 WT biofilm + macrophages + G-MDSCs; Staphylococcus aureus; RNA-Seq
4 ILLUMINA (NextSeq 500) runs: 11M spots, 1.6G bases, 574.3Mb downloads

External Id: GSM6585356_r1
Submitted by: Pathology & Microbiology, University of Nebraska Medical Center
Study: S. aureus biofilm transcriptome following G-MDSC or Macrophage co-culture
show Abstracthide Abstract
To investigate biofilm-leukocyte crosstalk, we performed RNA-seq to evaluate how the S. aureus biofilm transcriptome was altered following exposure to G-MDSCs or macrophages in vitro. Interestingly, each immune cell type elicited a distinct transcriptional response. Overall design: RNA-sequencing was performed on biofilm co-cultured with G-MDSCs (3 replicates), macrophages (3 replicates), or G-MDSCs + macrophages (2 replicates). Biofilm only was also used as a control (2 replicates).
Sample: 9 WT biofilm + macrophages + G-MDSCs
SAMN30859866 • SRS15122654 • All experiments • All runs
Library:
Name: GSM6585356
Instrument: NextSeq 500
Strategy: RNA-Seq
Source: TRANSCRIPTOMIC
Selection: cDNA
Layout: PAIRED
Construction protocol: RNA was isolated using beat-beating and TRIzol Reagent (Invitrogen) according to manufacturer's instructions. RNA sequencing libraries were prepared beginning with 250 ng of total RNA using a ScriptSeq Complete Kit (Bacterial) – Low Input protocol (Cat. No. SCL6B, Epicentre Technologies, Madison, WI). The protocol was performed as recommended by the manufacturer with the following modification at step 3.B.1. In order to remove both eukaryotic and prokaryotic ribosomal RNA from the total preparation, instead of using 2 ul of kit provided bacterial rRNA removal solution, 1 ul of RiboZero human / mouse / rat removal solution was mixed with 1 ul of the bacterial rRNA removal solution. In addition to the above, AMPure bead purification of rRNA-depleted sample was used in step 3.D.2 of the protocol.
Runs: 4 runs, 11M spots, 1.6G bases, 574.3Mb
Run# of Spots# of BasesSizePublished
SRR215813082,709,361406.7M141.8Mb2022-09-19
SRR215813092,811,246422.1M146.8Mb2022-09-19
SRR215813102,719,357408.1M142Mb2022-09-19
SRR215813112,738,120411M143.6Mb2022-09-19

ID:
24462688

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