show Abstracthide AbstractAll cancers are diseases of the genome. A combination of somatic point mutations, focal amplifications and deletions, and chromosome level aberrations conspire to disrupt gene expression and the interplay between signaling pathways that control normal growth and tissue homeostasis. Here we investigate transcript levels in 7 melanomas and a pool of melanocytes. Overall design: The transcriptome from 7 cutaneous melanomas and a pool of 2 normal melanocyte cultures was sequenced using the 454 technology