U.S. flag

An official website of the United States government


Send to:

Choose Destination

SRX8342974: Prevotella sp. PROD
1 ILLUMINA (Illumina HiSeq 2000) run: 3.7M spots, 736.9M bases, 418.3Mb downloads

Design: NEBNext-Ultra
Submitted by: Helmholtz Centre for Infection Research - HZI
Study: Distinct polysaccharide utilization as determinants for interspecies competition between intestinal Prevotella spp.
show Abstracthide Abstract
Prevotella spp. form one of the most dominant bacterial genera in the human gut. Multiple Prevotella spp. can co-exist in some but not all individuals consuming plant-based diets. To functionally investigate the relationship between Prevotella competition and diet, we isolated several novel Prevotella spp. from the mouse gut, performed genome and metatranscriptome analysis as well as a series of competition experiments under different dietary conditions. These experiments revealed that diverse dominant Prevotella species compete for similar metabolic niches in vivo, which is linked to the upregulation of specific Polysaccharide Utilization Loci (PULs). Complex plant-derived polysaccharides are required, and particularly arabinoxylan is sufficient, for the expansion of Prevotella spp. The most dominant Prevotella species encodes a specific tandem-repeat trsusC/D PUL, which is conserved in highly abundant Prevotella copri strains further expanded in humans consuming a vegan diet. Our data suggest efficient (arabino)xylan-utilization as a factor contributing to Prevotella dominance.
Sample: Prevotella rodentium
SAMN14906827 • SRS6660898 • All experiments • All runs
Name: PCHR_L001
Instrument: Illumina HiSeq 2000
Strategy: WGS
Selection: PCR
Layout: PAIRED
Runs: 1 run, 3.7M spots, 736.9M bases, 418.3Mb
Run# of Spots# of BasesSizePublished


Supplemental Content

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...