show Abstracthide AbstractThese metagenomic datasets were generated from inoculations of two different strains of the lactic acid bacteria O. oeni (one that is esterase positive and another that is esterase negative), and three strains of the wine spoilage yeast B. bruxellensis (CBS 73, CBS 2336 and CBS 2499) in Cabernet Sauvignon wine. We inoculated them alone and in combination with each other in order to evaluate the impact of their simultaneous occurrence in the total wine microbiome taxonomic and functional profiles, in particular their impact on flavor formation in the wine six months post-inoculation.