My Bibliography

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Shu Z, Dwivedi B, Switchenko JM, Yu DS, Deng X. PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer. Nat Commun. 2024 Aug 9;15(1):6830. doi: 10.1038/s41467-024-51242-8. PubMed PMID: 39122729; PubMed Central PMCID: PMC11316045.

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Head PE, Kapoor-Vazirani P, Nagaraju GP, Zhang H, Rath SK, Luong NC, Haji-Seyed-Javadi R, Sesay F, Wang SY, Duong DM, Daddacha W, Minten EV, Song B, Danelia D, Liu X, Li S, Ortlund EA, Seyfried NT, Smalley DM, Wang Y, Deng X, Dynan WS, El-Rayes B, Davis AJ, Yu DS. DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining. Nucleic Acids Res. 2023 Aug 25;51(15):7972-7987. doi: 10.1093/nar/gkad549. PubMed PMID: 37395399; PubMed Central PMCID: PMC10450170.

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Kapoor-Vazirani P, Rath SK, Liu X, Shu Z, Bowen NE, Chen Y, Haji-Seyed-Javadi R, Daddacha W, Minten EV, Danelia D, Farchi D, Duong DM, Seyfried NT, Deng X, Ortlund EA, Kim B, Yu DS. SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks. Nat Commun. 2022 Nov 7;13(1):6707. doi: 10.1038/s41467-022-34578-x. PubMed PMID: 36344525; PubMed Central PMCID: PMC9640623.

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Ma G, Deng Y, Qian L, Vallega KA, Zhang G, Deng X, Owonikoko TK, Ramalingam SS, Fang DD, Zhai Y, Sun SY. Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both. Oncogene. 2022 Mar;41(12):1691-1700. doi: 10.1038/s41388-022-02200-5. Epub 2022 Jan 31. PubMed PMID: 35102249; PubMed Central PMCID: PMC8969464.

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Park D, Anisuzzaman ASM, Magis AT, Chen G, Xie M, Zhang G, Behera M, Sica GL, Ramalingam SS, Owonikoko TK, Deng X. Discovery of Small Molecule Bak Activator for Lung Cancer Therapy. Theranostics. 2021;11(17):8500-8516. doi: 10.7150/thno.60349. eCollection 2021. PubMed PMID: 34373755; PubMed Central PMCID: PMC8344021.

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Kim MJ, Chen G, Sica GL, Deng X. Epigenetic modulation of FBW7/Mcl-1 pathway for lung cancer therapy. Cancer Biol Ther. 2021 Jan 2;22(1):55-65. doi: 10.1080/15384047.2020.1856756. Epub 2020 Dec 18. PubMed PMID: 33336620; PubMed Central PMCID: PMC7833779.

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Xie M, Park D, Sica GL, Deng X. Bcl2-induced DNA replication stress promotes lung carcinogenesis in response to space radiation. Carcinogenesis. 2020 Nov 13;41(11):1565-1575. doi: 10.1093/carcin/bgaa021. PubMed PMID: 32157295; PubMed Central PMCID: PMC8241220.

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Li Y, Zhang B, Xiang L, Xia S, Kucuk O, Deng X, Boise LH, Dong JT. TGF-β causes Docetaxel resistance in Prostate Cancer via the induction of Bcl-2 by acetylated KLF5 and Protein Stabilization. Theranostics. 2020;10(17):7656-7670. doi: 10.7150/thno.44567. eCollection 2020. PubMed PMID: 32685011; PubMed Central PMCID: PMC7359077.

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Koyen AE, Madden MZ, Park D, Minten EV, Kapoor-Vazirani P, Werner E, Pfister NT, Haji-Seyed-Javadi R, Zhang H, Xu J, Deng N, Duong DM, Pecen TJ, Frazier Z, Nagel ZD, Lazaro JB, Mouw KW, Seyfried NT, Moreno CS, Owonikoko TK, Deng X, Yu DS. EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair. Oncogene. 2020 Jun;39(25):4798-4813. doi: 10.1038/s41388-020-1332-2. Epub 2020 May 26. PubMed PMID: 32457468; PubMed Central PMCID: PMC7305988.

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Chen G, Park D, Magis AT, Behera M, Ramalingam SS, Owonikoko TK, Sica GL, Ye K, Zhang C, Chen Z, Curran WJ, Deng X. Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Cancer Res. 2019 Dec 15;79(24):6126-6138. doi: 10.1158/0008-5472.CAN-19-0950. Epub 2019 Oct 29. PubMed PMID: 31662324; PubMed Central PMCID: PMC6911632.

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Chen G, Luo Y, Warncke K, Sun Y, Yu DS, Fu H, Behera M, Ramalingam SS, Doetsch PW, Duong DM, Lammers M, Curran WJ, Deng X. Acetylation regulates ribonucleotide reductase activity and cancer cell growth. Nat Commun. 2019 Jul 19;10(1):3213. doi: 10.1038/s41467-019-11214-9. PubMed PMID: 31324785; PubMed Central PMCID: PMC6642173.

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Xu K, Park D, Magis AT, Zhang J, Zhou W, Sica GL, Ramalingam SS, Curran WJ, Deng X. Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy. Mol Cancer. 2019 Apr 10;18(1):85. doi: 10.1186/s12943-019-1012-4. PubMed PMID: 30971271; PubMed Central PMCID: PMC6456974.

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Chen G, Deng X. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8(17). doi: 10.21769/BioProtoc.2994. PubMed PMID: 30263905; PubMed Central PMCID: PMC6156087.

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Wang X, Beitler JJ, Huang W, Chen G, Qian G, Magliocca K, Patel MR, Chen AY, Zhang J, Nannapaneni S, Kim S, Chen Z, Deng X, Saba NF, Chen ZG, Arbiser JL, Shin DM. Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin. Clin Cancer Res. 2018 Feb 15;24(4):858-869. doi: 10.1158/1078-0432.CCR-17-0345. Epub 2017 Nov 27. PubMed PMID: 29180609; PubMed Central PMCID: PMC5815948.

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Chen G, Magis AT, Xu K, Park D, Yu DS, Owonikoko TK, Sica GL, Satola SW, Ramalingam SS, Curran WJ, Doetsch PW, Deng X. Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy. J Clin Invest. 2018 Jan 2;128(1):500-516. doi: 10.1172/JCI92742. Epub 2017 Dec 11. PubMed PMID: 29227281; PubMed Central PMCID: PMC5749500.

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Barrott JJ, Zhu JF, Smith-Fry K, Susko AM, Nollner D, Burrell LD, Pozner A, Capecchi MR, Yap JT, Cannon-Albright LA, Deng X, Jones KB. The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis. Mol Cancer Res. 2017 Dec;15(12):1733-1740. doi: 10.1158/1541-7786.MCR-17-0315. Epub 2017 Aug 29. PubMed PMID: 28851813; PubMed Central PMCID: PMC5816685.

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Liu W, Zhang B, Chen G, Wu W, Zhou L, Shi Y, Zeng Q, Li Y, Sun Y, Deng X, Wang F. Targeting miR-21 with Sophocarpine Inhibits Tumor Progression and Reverses Epithelial-Mesenchymal Transition in Head and Neck Cancer. Mol Ther. 2017 Sep 6;25(9):2129-2139. doi: 10.1016/j.ymthe.2017.05.008. Epub 2017 May 30. PubMed PMID: 28571917; PubMed Central PMCID: PMC5589060.

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Daddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, Minten EV, Whelan DR, Schlafstein AJ, Zhang H, Anand R, Doronio C, Withers AE, Shepard C, Sundaram RK, Deng X, Dynan WS, Wang Y, Bindra RS, Cejka P, Rothenberg E, Doetsch PW, Kim B, Yu DS. SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. Cell Rep. 2017 Aug 22;20(8):1921-1935. doi: 10.1016/j.celrep.2017.08.008. PubMed PMID: 28834754; PubMed Central PMCID: PMC5576576.

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Li R, Ding C, Zhang J, Xie M, Park D, Ding Y, Chen G, Zhang G, Gilbert-Ross M, Zhou W, Marcus AI, Sun SY, Chen ZG, Sica GL, Ramalingam SS, Magis AT, Fu H, Khuri FR, Curran WJ, Owonikoko TK, Shin DM, Zhou J, Deng X. Modulation of Bax and mTOR for Cancer Therapeutics. Cancer Res. 2017 Jun 1;77(11):3001-3012. doi: 10.1158/0008-5472.CAN-16-2356. Epub 2017 Apr 5. PubMed PMID: 28381544; PubMed Central PMCID: PMC5503158.

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Yang LL, Liu BC, Lu XY, Yan Y, Zhai YJ, Bao Q, Doetsch PW, Deng X, Thai TL, Alli AA, Eaton DC, Shen BZ, Ma HP. Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion. Oncotarget. 2017 Jan 17;8(3):5123-5134. doi: 10.18632/oncotarget.14034. PubMed PMID: 28030826; PubMed Central PMCID: PMC5341750.

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Park D, Wang D, Chen G, Deng X. Establishment of Patient-derived Xenografts in Mice. Bio Protoc. 2016 Nov 20;6(22). doi: 10.21769/BioProtoc.2008. PubMed PMID: 28184379; PubMed Central PMCID: PMC5293284.

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Zhang J, Dai Q, Park D, Deng X. Targeting DNA Replication Stress for Cancer Therapy. Genes (Basel). 2016 Aug 19;7(8). doi: 10.3390/genes7080051. Review. PubMed PMID: 27548226; PubMed Central PMCID: PMC4999839.

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Deng J, Park D, Wang M, Nooka A, Deng Q, Matulis S, Kaufman J, Lonial S, Boise LH, Galipeau J, Deng X. BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth. Oncotarget. 2016 May 10;7(19):27753-63. doi: 10.18632/oncotarget.8513. PubMed PMID: 27049723; PubMed Central PMCID: PMC5053685.

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Owonikoko TK, Zhang G, Kim HS, Stinson RM, Bechara R, Zhang C, Chen Z, Saba NF, Pakkala S, Pillai R, Deng X, Sun SY, Rossi MR, Sica GL, Ramalingam SS, Khuri FR. Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer. J Transl Med. 2016 May 3;14(1):111. doi: 10.1186/s12967-016-0861-5. PubMed PMID: 27142472; PubMed Central PMCID: PMC4855771.

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Zhang H, Head PE, Daddacha W, Park SH, Li X, Pan Y, Madden MZ, Duong DM, Xie M, Yu B, Warren MD, Liu EA, Dhere VR, Li C, Pradilla I, Torres MA, Wang Y, Dynan WS, Doetsch PW, Deng X, Seyfried NT, Gius D, Yu DS. ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. Cell Rep. 2016 Feb 16;14(6):1435-1447. doi: 10.1016/j.celrep.2016.01.018. Epub 2016 Feb 4. PubMed PMID: 26854234; PubMed Central PMCID: PMC4758896.

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Zhang J, Park D, Shin DM, Deng X. Targeting KRAS-mutant non-small cell lung cancer: challenges and opportunities. Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):11-6. doi: 10.1093/abbs/gmv118. Epub 2015 Nov 17. Review. PubMed PMID: 26578706; PubMed Central PMCID: PMC4689161.

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Chen G, Deng X. Targeting Bcl2 in cancer. Oncoscience. 2015;2(10):813-4. doi: 10.18632/oncoscience.232. eCollection 2015. PubMed PMID: 26682258; PubMed Central PMCID: PMC4671933.

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Xie M, Doetsch PW, Deng X. Bcl2 inhibition of mitochondrial DNA repair. BMC Cancer. 2015 Aug 13;15:586. doi: 10.1186/s12885-015-1594-1. PubMed PMID: 26268226; PubMed Central PMCID: PMC4535531.

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Koo J, Yue P, Deng X, Khuri FR, Sun SY. mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation. Mol Cell Biol. 2015 Jul;35(13):2344-55. doi: 10.1128/MCB.01525-14. Epub 2015 Apr 27. PubMed PMID: 25918246; PubMed Central PMCID: PMC4456440.

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Han B, Park D, Li R, Xie M, Owonikoko TK, Zhang G, Sica GL, Ding C, Zhou J, Magis AT, Chen ZG, Shin DM, Ramalingam SS, Khuri FR, Curran WJ, Deng X. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer Cell. 2015 Jun 8;27(6):852-63. doi: 10.1016/j.ccell.2015.04.010. Epub 2015 May 21. PubMed PMID: 26004684; PubMed Central PMCID: PMC4470473.

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Owonikoko TK, Ramalingam SS, Miller DL, Force SD, Sica GL, Mendel J, Chen Z, Rogatko A, Tighiouart M, Harvey RD, Kim S, Saba NF, Pickens A, Behera M, Fu RW, Rossi MR, Auffermann WF, Torres WE, Bechara R, Deng X, Sun SY, Fu H, Gal AA, Khuri FR. A Translational, Pharmacodynamic, and Pharmacokinetic Phase IB Clinical Study of Everolimus in Resectable Non-Small Cell Lung Cancer. Clin Cancer Res. 2015 Apr 15;21(8):1859-68. doi: 10.1158/1078-0432.CCR-14-1998. Epub 2015 Feb 11. PubMed PMID: 25673697; PubMed Central PMCID: PMC4401630.

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Xie M, Park D, You S, Li R, Owonikoko TK, Wang Y, Doetsch PW, Deng X. Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation. Nucleic Acids Res. 2015 Jan;43(2):960-72. doi: 10.1093/nar/gku1358. Epub 2015 Jan 7. PubMed PMID: 25567982; PubMed Central PMCID: PMC4333404.

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Owonikoko TK, Zhang G, Deng X, Rossi MR, Switchenko JM, Doho GH, Chen Z, Kim S, Strychor S, Christner SM, Beumer J, Li C, Yue P, Chen A, Sica GL, Ramalingam SS, Kowalski J, Khuri FR, Sun SY. Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer. Cancer Med. 2014 Dec;3(6):1579-94. doi: 10.1002/cam4.317. Epub 2014 Aug 13. PubMed PMID: 25124282; PubMed Central PMCID: PMC4298385.

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Higgins KA, Park D, Lee GY, Curran WJ, Deng X. Exercise-induced lung cancer regression: mechanistic findings from a mouse model. Cancer. 2014 Nov 1;120(21):3302-3310. doi: 10.1002/cncr.28878. Epub 2014 Jul 2. PubMed PMID: 24989479; PubMed Central PMCID: PMC4682566.

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Wang H, Wang X, Chen G, Zhang X, Tang X, Park D, Cucinotta FA, Yu DS, Deng X, Dynan WS, Doetsch PW, Wang Y. Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing. J Biol Chem. 2014 Oct 31;289(44):30635-30644. doi: 10.1074/jbc.M114.604959. Epub 2014 Sep 10. PubMed PMID: 25210033; PubMed Central PMCID: PMC4215242.

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Xin M, Li R, Xie M, Park D, Owonikoko TK, Sica GL, Corsino PE, Zhou J, Ding C, White MA, Magis AT, Ramalingam SS, Curran WJ, Khuri FR, Deng X. Small-molecule Bax agonists for cancer therapy. Nat Commun. 2014 Sep 17;5:4935. doi: 10.1038/ncomms5935. PubMed PMID: 25230299; PubMed Central PMCID: PMC4172359.

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Xiao L, Hu ZY, Dong X, Tan Z, Li W, Tang M, Chen L, Yang L, Tao Y, Jiang Y, Li J, Yi B, Li B, Fan S, You S, Deng X, Hu F, Feng L, Bode AM, Dong Z, Sun LQ, Cao Y. Targeting Epstein-Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy. Oncogene. 2014 Sep 11;33(37):4568-78. doi: 10.1038/onc.2014.32. Epub 2014 Mar 24. PubMed PMID: 24662831; PubMed Central PMCID: PMC4162460.

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Wang B, Xie M, Li R, Owonikoko TK, Ramalingam SS, Khuri FR, Curran WJ, Wang Y, Deng X. Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis. Cell Death Differ. 2014 Jul;21(7):1160-9. doi: 10.1038/cdd.2014.42. Epub 2014 Apr 25. PubMed PMID: 24769731; PubMed Central PMCID: PMC4207484.

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Deng X. Bcl2 Family Functions as Signaling Target in Nicotine-/NNK-Induced Survival of Human Lung Cancer Cells. Scientifica (Cairo). 2014;2014:215426. doi: 10.1155/2014/215426. Epub 2014 May 20. Review. PubMed PMID: 24967145; PubMed Central PMCID: PMC4054617.

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You S, Li R, Park D, Xie M, Sica GL, Cao Y, Xiao ZQ, Deng X. Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer. Mol Cancer Ther. 2014 Mar;13(3):606-16. doi: 10.1158/1535-7163.MCT-13-0608. Epub 2013 Dec 20. PubMed PMID: 24362463; PubMed Central PMCID: PMC3964811.

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Mohamed A, Deng X, Khuri FR, Owonikoko TK. Altered glutamine metabolism and therapeutic opportunities for lung cancer. Clin Lung Cancer. 2014 Jan;15(1):7-15. doi: 10.1016/j.cllc.2013.09.001. Epub 2013 Nov 13. Review. PubMed PMID: 24377741; PubMed Central PMCID: PMC3970234.

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Xie M, Yen Y, Owonikoko TK, Ramalingam SS, Khuri FR, Curran WJ, Doetsch PW, Deng X. Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase. Cancer Res. 2014 Jan 1;74(1):212-23. doi: 10.1158/0008-5472.CAN-13-1536-T. Epub 2013 Nov 6. PubMed PMID: 24197132; PubMed Central PMCID: PMC3887143.

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Ren H, Koo J, Guan B, Yue P, Deng X, Chen M, Khuri FR, Sun SY. The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. Mol Cancer. 2013 Nov 22;12:146. doi: 10.1186/1476-4598-12-146. PubMed PMID: 24261825; PubMed Central PMCID: PMC3924345.

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Ma X, Xu Z, Yang L, Xiao L, Tang M, Lu J, Xu S, Tang Y, Wen X, Deng X, Sun L, Cao Y. EBV-LMP1-targeted DNAzyme induces DNA damage and causes cell cycle arrest in LMP1-positive nasopharyngeal carcinoma cells. Int J Oncol. 2013 Nov;43(5):1541-8. doi: 10.3892/ijo.2013.2098. Epub 2013 Sep 13. PubMed PMID: 24042231.

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Li R, Hu Z, Sun SY, Chen ZG, Owonikoko TK, Sica GL, Ramalingam SS, Curran WJ, Khuri FR, Deng X. Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther. 2013 Oct;12(10):2200-12. doi: 10.1158/1535-7163.MCT-13-0095. Epub 2013 Jul 26. PubMed PMID: 23894143; PubMed Central PMCID: PMC3795834.

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Ren H, Zhao L, Li Y, Yue P, Deng X, Owonikoko TK, Chen M, Khuri FR, Sun SY. The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis. Cancer Lett. 2013 Sep 28;338(2):229-38. doi: 10.1016/j.canlet.2013.03.032. Epub 2013 Apr 2. PubMed PMID: 23562472; PubMed Central PMCID: PMC3750077.

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Li R, You S, Hu Z, Chen ZG, Sica GL, Khuri FR, Curran WJ, Shin DM, Deng X. Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer. PLoS One. 2013;8(9):e74670. doi: 10.1371/journal.pone.0074670. eCollection 2013. PubMed PMID: 24019973; PubMed Central PMCID: PMC3760825.

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Park D, Magis AT, Li R, Owonikoko TK, Sica GL, Sun SY, Ramalingam SS, Khuri FR, Curran WJ, Deng X. Novel small-molecule inhibitors of Bcl-XL to treat lung cancer. Cancer Res. 2013 Sep 1;73(17):5485-96. doi: 10.1158/0008-5472.CAN-12-2272. Epub 2013 Jul 3. PubMed PMID: 23824742; PubMed Central PMCID: PMC3774010.

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Zeng GQ, Yi H, Zhang PF, Li XH, Hu R, Li MY, Li C, Qu JQ, Deng X, Xiao ZQ. The function and significance of SELENBP1 downregulation in human bronchial epithelial carcinogenic process. PLoS One. 2013;8(8):e71865. doi: 10.1371/journal.pone.0071865. eCollection 2013. PubMed PMID: 23977169; PubMed Central PMCID: PMC3747066.

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Hagen KR, Zeng X, Lee MY, Tucker Kahn S, Harrison Pitner MK, Zaky SS, Liu Y, O'Regan RM, Deng X, Saavedra HI. Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis. Cell Div. 2013 Jul 25;8(1):10. doi: 10.1186/1747-1028-8-10. PubMed PMID: 23886499; PubMed Central PMCID: PMC3733890.