My Bibliography

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Leahy C, Osborne N, Shirota L, Rote P, Lee YK, Song BJ, Yin L, Zhang Y, Garcia V, Hardwick JP. The fatty acid omega hydroxylase genes (CYP4 family) in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD): An RNA sequence database analysis and review. Biochem Pharmacol. 2024 Oct;228:116241. doi: 10.1016/j.bcp.2024.116241. Epub 2024 May 1. Review. PubMed PMID: 38697309.

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Signoretti C, Matsumura S, Fatehi S, D'Silva M, Mathew R, Cendali F, D'Alessandro A, Alam SMS, Garcia V, Miano JM, Gupte SA. G6pd(N126D) Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease. J Am Heart Assoc. 2024 Oct;13(19):e035174. doi: 10.1161/JAHA.123.035174. Epub 2024 Sep 18. PubMed PMID: 39291493.

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Matsumura S, Signoretti C, Fatehi S, Tumenbayar BI, D'Addario C, Nimmer E, Thomas C, Viswanathan T, Wolf A, Garcia V, Rocic P, Bae Y, Alam SS, Gupte SA. Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats. J Biol Chem. 2024 Jul;300(7):107460. doi: 10.1016/j.jbc.2024.107460. Epub 2024 Jun 12. PubMed PMID: 38876306; PubMed Central PMCID: PMC11328872.

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Hossain S, Gilani A, Pascale J, Villegas E, Diegisser D, Agostinucci K, Kulaprathazhe MM, Dirice E, Garcia V, Schwartzman ML. Gpr75-deficient mice are protected from high-fat diet-induced obesity. Obesity (Silver Spring). 2023 Apr;31(4):1024-1037. doi: 10.1002/oby.23692. Epub 2023 Feb 28. PubMed PMID: 36854900; PubMed Central PMCID: PMC10033368.

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Pascale JV, Wolf A, Kadish Y, Diegisser D, Kulaprathazhe MM, Yemane D, Ali S, Kim N, Baruch DE, Yahaya MAF, Dirice E, Adebesin AM, Falck JR, Schwartzman ML, Garcia V. 20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond. Adv Pharmacol. 2023;97:229-255. doi: 10.1016/bs.apha.2023.01.002. Epub 2023 Feb 24. PubMed PMID: 37236760; PubMed Central PMCID: PMC10683332.

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Li K, Yu XH, Maskey AR, Musa I, Wang ZZ, Garcia V, Guo A, Yang N, Srivastava K, Dunkin D, Li JX, Guo L, Cheng YC, Yuan H, Tiwari R, Li XM. Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid. Front Pharmacol. 2022;13:1042756. doi: 10.3389/fphar.2022.1042756. eCollection 2022. PubMed PMID: 36793921; PubMed Central PMCID: PMC9922998.

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Publisher Correction: The importance of "Fit": an interview with Victor Garcia on vascular biology and enjoying the scientific journey. Commun Biol. 2022 May 5;5(1):443. doi: 10.1038/s42003-022-03386-w. PubMed PMID: 35513497; PubMed Central PMCID: PMC9072420.

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McClung JA, Levy L, Garcia V, Stec DE, Peterson SJ, Abraham NG. Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications. Pharmacol Ther. 2022 Mar;231:107975. doi: 10.1016/j.pharmthera.2021.107975. Epub 2021 Sep 6. Review. PubMed PMID: 34499923; PubMed Central PMCID: PMC8958338.

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Agostinucci K, Hutcheson R, Hossain S, Pascale JV, Villegas E, Zhang F, Adebesin AM, Falck JR, Gupte S, Garcia V, Schwartzman ML. Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase. J Hypertens. 2022 Mar 1;40(3):498-511. doi: 10.1097/HJH.0000000000003038. PubMed PMID: 35081581; PubMed Central PMCID: PMC8820380.

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The CYP/20-HETE/GPR75 axis in hypertension. In: Advances in Pharmacology https://doi.org/10.1016/bs.apha.2022.02.003: Academic Press; 2022.

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Pascale JV, Park EJ, Adebesin AM, Falck JR, Schwartzman ML, Garcia V. Uncovering the signalling, structure and function of the 20-HETE-GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75. Br J Pharmacol. 2021 Sep;178(18):3813-3828. doi: 10.1111/bph.15525. Epub 2021 Jun 15. PubMed PMID: 33974269; PubMed Central PMCID: PMC10119890.

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Akbari P, Gilani A, Sosina O, Kosmicki JA, Khrimian L, Fang YY, Persaud T, Garcia V, Sun D, Li A, Mbatchou J, Locke AE, Benner C, Verweij N, Lin N, Hossain S, Agostinucci K, Pascale JV, Dirice E, Dunn M, Kraus WE, Shah SH, Chen YI, Rotter JI, Rader DJ, Melander O, Still CD, Mirshahi T, Carey DJ, Berumen-Campos J, Kuri-Morales P, Alegre-Díaz J, Torres JM, Emberson JR, Collins R, Balasubramanian S, Hawes A, Jones M, Zambrowicz B, Murphy AJ, Paulding C, Coppola G, Overton JD, Reid JG, Shuldiner AR, Cantor M, Kang HM, Abecasis GR, Karalis K, Economides AN, Marchini J, Yancopoulos GD, Sleeman MW, Altarejos J, Della Gatta G, Tapia-Conyer R, Schwartzman ML, Baras A, Ferreira MAR, Lotta LA. Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity. Science. 2021 Jul 2;373(6550). doi: 10.1126/science.abf8683. PubMed PMID: 34210852; PubMed Central PMCID: PMC10275396.

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Pascale JV, Lucchesi PA, Garcia V. Unraveling the Role of 12- and 20- HETE in Cardiac Pathophysiology: G-Protein-Coupled Receptors, Pharmacological Inhibitors, and Transgenic Approaches. J Cardiovasc Pharmacol. 2021 Jun 1;77(6):707-717. doi: 10.1097/FJC.0000000000001013. Review. PubMed PMID: 34016841; PubMed Central PMCID: PMC8523029.

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Gilani A, Agostinucci K, Hossain S, Pascale JV, Garcia V, Adebesin AM, Falck JR, Schwartzman ML. 20-HETE interferes with insulin signaling and contributes to obesity-driven insulin resistance. Prostaglandins Other Lipid Mediat. 2021 Feb;152:106485. doi: 10.1016/j.prostaglandins.2020.106485. Epub 2020 Oct 1. PubMed PMID: 33011364; PubMed Central PMCID: PMC7855891.

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Gilani A, Agostinucci K, Pascale JV, Hossain S, Kandhi S, Pandey V, Garcia V, Nasjletti A, Laniado Schwartzman M. Proximal tubular-targeted overexpression of the Cyp4a12-20-HETE synthase promotes salt-sensitive hypertension in male mice. Am J Physiol Regul Integr Comp Physiol. 2020 Jun 17;319(1):R87-95. doi: 10.1152/ajpregu.00089.2020. [Epub ahead of print] PubMed PMID: 32633545; PubMed Central PMCID: PMC7468799.

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Garcia V, Park EJ, Siragusa M, Frohlich F, Mahfuzul Haque M, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, Sessa WC. Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9497-9507. doi: 10.1073/pnas.1918761117. Epub 2020 Apr 16. PubMed PMID: 32300005; PubMed Central PMCID: PMC7196906.

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Dakarapu R, Errabelli R, Manthati VL, Michael Adebesin A, Barma DK, Barma D, Garcia V, Zhang F, Laniado Schwartzman M, Falck JR. 19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126616. doi: 10.1016/j.bmcl.2019.08.020. Epub 2019 Aug 13. PubMed PMID: 31439380; PubMed Central PMCID: PMC6745249.

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Chen L, Tang S, Zhang FF, Garcia V, Falck JR, Schwartzman ML, Arbab AS, Guo AM. CYP4A/20-HETE regulates ischemia-induced neovascularization via its actions on endothelial progenitor and preexisting endothelial cells. Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1468-H1479. doi: 10.1152/ajpheart.00690.2018. Epub 2019 Apr 5. PubMed PMID: 30951365; PubMed Central PMCID: PMC6620690.

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Garcia V, Sessa WC. Endothelial NOS: perspective and recent developments. Br J Pharmacol. 2019 Jan;176(2):189-196. doi: 10.1111/bph.14522. Epub 2018 Dec 9. Review. PubMed PMID: 30341769; PubMed Central PMCID: PMC6295413.

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Gilani A, Pandey V, Garcia V, Agostinucci K, Singh SP, Schragenheim J, Bellner L, Falck JR, Paudyal MP, Capdevila JH, Abraham NG, Laniado Schwartzman M. High-fat diet-induced obesity and insulin resistance in CYP4a14(-/-) mice is mediated by 20-HETE. Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R934-R944. doi: 10.1152/ajpregu.00125.2018. Epub 2018 Aug 8. PubMed PMID: 30088983; PubMed Central PMCID: PMC6295494.

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Pandey V, Garcia V, Gilani A, Mishra P, Zhang FF, Paudyal MP, Falck JR, Nasjletti A, Wang WH, Schwartzman ML. The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis. J Pharmacol Exp Ther. 2017 Dec;363(3):412-418. doi: 10.1124/jpet.117.243618. Epub 2017 Sep 14. PubMed PMID: 28912346; PubMed Central PMCID: PMC5698946.

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Garcia V, Gilani A, Shkolnik B, Pandey V, Zhang FF, Dakarapu R, Gandham SK, Reddy NR, Graves JP, Gruzdev A, Zeldin DC, Capdevila JH, Falck JR, Schwartzman ML. 20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (G(q)) to Affect Vascular Function and Trigger Hypertension. Circ Res. 2017 May 26;120(11):1776-1788. doi: 10.1161/CIRCRESAHA.116.310525. Epub 2017 Mar 21. PubMed PMID: 28325781; PubMed Central PMCID: PMC5446268.

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Garcia V, Schwartzman ML. Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid. Curr Opin Nephrol Hypertens. 2017 Mar;26(2):74-82. doi: 10.1097/MNH.0000000000000302. Review. PubMed PMID: 27906746.

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Dordea AC, Vandenwijngaert S, Garcia V, Tainsh RE, Nathan DI, Allen K, Raher MJ, Tainsh LT, Zhang F, Lieb WS, Mikelman S, Kirby A, Stevens C, Thoonen R, Hindle AG, Sips PY, Falck JR, Daly MJ, Brouckaert P, Bloch KD, Bloch DB, Malhotra R, Schwartzman ML, Buys ES. Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1790-800. doi: 10.1152/ajpheart.00877.2015. Epub 2016 May 3. PubMed PMID: 27199131; PubMed Central PMCID: PMC4935526.

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Garcia V, Shkolnik B, Milhau L, Falck JR, Schwartzman ML. 20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding. J Pharmacol Exp Ther. 2016 Mar;356(3):525-33. doi: 10.1124/jpet.115.229377. Epub 2015 Dec 23. PubMed PMID: 26699146; PubMed Central PMCID: PMC4767392.

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Hoopes SL, Garcia V, Edin ML, Schwartzman ML, Zeldin DC. Vascular actions of 20-HETE. Prostaglandins Other Lipid Mediat. 2015 Jul;120:9-16. doi: 10.1016/j.prostaglandins.2015.03.002. Epub 2015 Mar 23. Review. PubMed PMID: 25813407; PubMed Central PMCID: PMC4575602.

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Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang FF, Gotlinger K, Falck JR, Dakarapu R, Capdevila JH, Bernstein KE, Schwartzman ML. Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension. Am J Physiol Regul Integr Comp Physiol. 2015 Jul 1;309(1):R71-8. doi: 10.1152/ajpregu.00039.2015. Epub 2015 Apr 29. PubMed PMID: 25924878; PubMed Central PMCID: PMC4491537.

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Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. J Am Soc Nephrol. 2015 Mar;26(3):597-610. doi: 10.1681/ASN.2013090980. Epub 2014 Jul 28. PubMed PMID: 25071086; PubMed Central PMCID: PMC4341468.

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Garcia V, Cheng J, Weidenhammer A, Ding Y, Wu CC, Zhang F, Gotlinger K, Falck JR, Schwartzman ML. Androgen-induced hypertension in angiotensinogen deficient mice: role of 20-HETE and EETS. Prostaglandins Other Lipid Mediat. 2015 Jan-Mar;116-117:124-30. doi: 10.1016/j.prostaglandins.2014.12.001. Epub 2014 Dec 17. PubMed PMID: 25526688; PubMed Central PMCID: PMC4385421.

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Cheng J, Edin ML, Hoopes SL, Li H, Bradbury JA, Graves JP, DeGraff LM, Lih FB, Garcia V, Shaik JS, Tomer KB, Flake GP, Falck JR, Lee CR, Poloyac SM, Schwartzman ML, Zeldin DC. Vascular characterization of mice with endothelial expression of cytochrome P450 4F2. FASEB J. 2014 Jul;28(7):2915-31. doi: 10.1096/fj.13-241927. Epub 2014 Mar 25. PubMed PMID: 24668751; PubMed Central PMCID: PMC4062824.

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Wu CC, Gupta T, Garcia V, Ding Y, Schwartzman ML. 20-HETE and blood pressure regulation: clinical implications. Cardiol Rev. 2014 Jan-Feb;22(1):1-12. doi: 10.1097/CRD.0b013e3182961659. Review. PubMed PMID: 23584425; PubMed Central PMCID: PMC4292790.

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Ding Y, Wu CC, Garcia V, Dimitrova I, Weidenhammer A, Joseph G, Zhang F, Manthati VL, Falck JR, Capdevila JH, Schwartzman ML. 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F753-63. doi: 10.1152/ajprenal.00292.2013. Epub 2013 Jul 3. PubMed PMID: 23825080; PubMed Central PMCID: PMC3761206.

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Wu CC, Mei S, Cheng J, Ding Y, Weidenhammer A, Garcia V, Zhang F, Gotlinger K, Manthati VL, Falck JR, Capdevila JH, Schwartzman ML. Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase. J Am Soc Nephrol. 2013 Jul;24(8):1288-96. doi: 10.1681/ASN.2012070714. Epub 2013 May 2. PubMed PMID: 23641057; PubMed Central PMCID: PMC3736709.

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Cheng J, Garcia V, Ding Y, Wu CC, Thakar K, Falck JR, Ramu E, Schwartzman ML. Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1917-24. doi: 10.1161/ATVBAHA.112.248344. Epub 2012 Jun 21. PubMed PMID: 22723444; PubMed Central PMCID: PMC3418056.

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Rémond MC, Iaffaldano G, O'Quinn MP, Mezentseva NV, Garcia V, Harris BS, Gourdie RG, Eisenberg CA, Eisenberg LM. GATA6 reporter gene reveals myocardial phenotypic heterogeneity that is related to variations in gap junction coupling. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1952-64. doi: 10.1152/ajpheart.00635.2011. Epub 2011 Sep 9. PubMed PMID: 21908788; PubMed Central PMCID: PMC3213955.