My Bibliography

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Delgado BD, Long SB. Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter. Sci Adv. 2022 Dec 16;8(50):eade1516. doi: 10.1126/sciadv.ade1516. Epub 2022 Dec 16. PubMed PMID: 36525497; PubMed Central PMCID: PMC9757755.

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Wang C, Polovitskaya MM, Delgado BD, Jentsch TJ, Long SB. Gating choreography and mechanism of the human proton-activated chloride channel ASOR. Sci Adv. 2022 Feb 4;8(5):eabm3942. doi: 10.1126/sciadv.abm3942. Epub 2022 Feb 2. PubMed PMID: 35108041; PubMed Central PMCID: PMC8809534.

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Jiang Y, Benz TL, Long SB. Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT. Science. 2021 Jun 11;372(6547):1215-1219. doi: 10.1126/science.abg4998. PubMed PMID: 34112694; PubMed Central PMCID: PMC8734478.

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Hou X, Outhwaite IR, Pedi L, Long SB. Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. Elife. 2020 Nov 30;9. doi: 10.7554/eLife.62772. PubMed PMID: 33252040; PubMed Central PMCID: PMC7723414.

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Wang C, Baradaran R, Long SB. Structure and Reconstitution of an MCU-EMRE Mitochondrial Ca(2+) Uniporter Complex. J Mol Biol. 2020 Sep 18;432(20):5632-5648. doi: 10.1016/j.jmb.2020.08.013. Epub 2020 Aug 22. PubMed PMID: 32841658; PubMed Central PMCID: PMC7577567.

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Wang C, Jacewicz A, Delgado BD, Baradaran R, Long SB. Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2. Elife. 2020 Jul 15;9. doi: 10.7554/eLife.59991. PubMed PMID: 32667285; PubMed Central PMCID: PMC7434445.

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Miller AN, Vaisey G, Long SB. Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin. Elife. 2019 Jan 10;8. doi: 10.7554/eLife.43231. PubMed PMID: 30628889; PubMed Central PMCID: PMC6342527.

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Vaisey G, Long SB. An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1. J Gen Physiol. 2018 Nov 5;150(11):1484-1497. doi: 10.1085/jgp.201812190. Epub 2018 Sep 20. PubMed PMID: 30237227; PubMed Central PMCID: PMC6219684.

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Hou X, Burstein SR, Long SB. Structures reveal opening of the store-operated calcium channel Orai. Elife. 2018 Aug 30;7. doi: 10.7554/eLife.36758. PubMed PMID: 30160233; PubMed Central PMCID: PMC6170153.

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Baradaran R, Wang C, Siliciano AF, Long SB. Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters. Nature. 2018 Jul;559(7715):580-584. doi: 10.1038/s41586-018-0331-8. Epub 2018 Jul 11. PubMed PMID: 29995857; PubMed Central PMCID: PMC6336196.

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Diver MM, Pedi L, Koide A, Koide S, Long SB. Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT. Nature. 2018 Jan 25;553(7689):526-529. doi: 10.1038/nature25439. Epub 2018 Jan 17. PubMed PMID: 29342140; PubMed Central PMCID: PMC5785467.

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Vaisey G, Miller AN, Long SB. Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7399-E7408. doi: 10.1073/pnas.1614688113. Epub 2016 Nov 7. PubMed PMID: 27821745; PubMed Central PMCID: PMC5127342.

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Kane Dickson V, Pedi L, Long SB. Structure and insights into the function of a Ca(2+)-activated Cl(-) channel. Nature. 2014 Dec 11;516(7530):213-8. doi: 10.1038/nature13913. Epub 2014 Oct 22. PubMed PMID: 25337878; PubMed Central PMCID: PMC4454446.

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Diver MM, Long SB. Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites. J Biol Chem. 2014 Sep 19;289(38):26007-26020. doi: 10.1074/jbc.M114.585125. Epub 2014 Jul 24. PubMed PMID: 25059662; PubMed Central PMCID: PMC4176209.

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Hou X, Pedi L, Diver MM, Long SB. Crystal structure of the calcium release-activated calcium channel Orai. Science. 2012 Dec 7;338(6112):1308-13. doi: 10.1126/science.1228757. Epub 2012 Nov 22. PubMed PMID: 23180775; PubMed Central PMCID: PMC3695727.

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Miller AN, Long SB. Crystal structure of the human two-pore domain potassium channel K2P1. Science. 2012 Jan 27;335(6067):432-6. doi: 10.1126/science.1213274. PubMed PMID: 22282804.

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Li W, You L, Cooper J, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG. Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell. 2010 Feb 19;140(4):477-90. doi: 10.1016/j.cell.2010.01.029. PubMed PMID: 20178741; PubMed Central PMCID: PMC2828953.

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Nimjee SM, Oney S, Volovyk Z, Bompiani KM, Long SB, Hoffman M, Sullenger BA. Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin. RNA. 2009 Dec;15(12):2105-11. doi: 10.1261/rna.1240109. Epub 2009 Oct 21. PubMed PMID: 19846574; PubMed Central PMCID: PMC2779679.

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Long SB, Long MB, White RR, Sullenger BA. Crystal structure of an RNA aptamer bound to thrombin. RNA. 2008 Dec;14(12):2504-12. doi: 10.1261/rna.1239308. Epub 2008 Oct 29. PubMed PMID: 18971322; PubMed Central PMCID: PMC2590953.

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Long SB, Tao X, Campbell EB, MacKinnon R. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature. 2007 Nov 15;450(7168):376-82. doi: 10.1038/nature06265. PubMed PMID: 18004376.

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Long SB, Campbell EB, Mackinnon R. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science. 2005 Aug 5;309(5736):903-8. doi: 10.1126/science.1116270. Epub 2005 Jul 7. PubMed PMID: 16002579.

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Long SB, Campbell EB, Mackinnon R. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science. 2005 Aug 5;309(5736):897-903. doi: 10.1126/science.1116269. Epub 2005 Jul 7. PubMed PMID: 16002581.

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Reid TS, Long SB, Beese LS. Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes. Biochemistry. 2004 Jul 20;43(28):9000-8. doi: 10.1021/bi049280b. PubMed PMID: 15248757.

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Long SB, Casey PJ, Beese LS. Reaction path of protein farnesyltransferase at atomic resolution. Nature. 2002 Oct 10;419(6907):645-50. doi: 10.1038/nature00986. PubMed PMID: 12374986.

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Long SB, Hancock PJ, Kral AM, Hellinga HW, Beese LS. The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12948-53. doi: 10.1073/pnas.241407898. Epub 2001 Oct 30. PubMed PMID: 11687658; PubMed Central PMCID: PMC60805.

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Long SB, Casey PJ, Beese LS. The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. Structure. 2000 Feb 15;8(2):209-22. doi: 10.1016/s0969-2126(00)00096-4. PubMed PMID: 10673434.

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Long SB, Casey PJ, Beese LS. Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate. Biochemistry. 1998 Jul 7;37(27):9612-8. doi: 10.1021/bi980708e. PubMed PMID: 9657673.