My Bibliography

select

Ni P, Fan L, Jiang Y, Zhou C, Chung S. From cells to insights: the power of human pluripotent stem cell-derived cortical interneurons in psychiatric disorder modeling. Front Psychiatry. 2023;14:1336085. doi: 10.3389/fpsyt.2023.1336085. eCollection 2023. Review. PubMed PMID: 38188058; PubMed Central PMCID: PMC10768008.

select

Ni P, Zhou C, Liang S, Jiang Y, Liu D, Shao Z, Noh H, Zhao L, Tian Y, Zhang C, Wei J, Li X, Yu H, Ni R, Yu X, Qi X, Zhang Y, Ma X, Deng W, Guo W, Wang Q, Sham PC, Chung S, Li T. YBX1-Mediated DNA Methylation-Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia. Adv Sci (Weinh). 2023 Jul;10(20):e2300455. doi: 10.1002/advs.202300455. Epub 2023 May 21. PubMed PMID: 37211699; PubMed Central PMCID: PMC10369273.

select

Zhu Q, Mishra A, Park JS, Liu D, Le DT, Gonzalez SZ, Anderson-Crannage M, Park JM, Park GH, Tarbay L, Daneshvar K, Brandenburg M, Signoretti C, Zinski A, Gardner EJ, Zheng KL, Abani CP, Hu C, Beaudreault CP, Zhang XL, Stanton PK, Cho JH, Velíšek L, Velíšková J, Javed S, Leonard CS, Kim HY, Chung S. Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition. Neuron. 2023 Mar 15;111(6):807-823.e7. doi: 10.1016/j.neuron.2022.12.014. Epub 2023 Jan 9. PubMed PMID: 36626901; PubMed Central PMCID: PMC10023356.

select

Xu J, Fang S, Deng S, Li H, Lin X, Huang Y, Chung S, Shu Y, Shao Z. Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes. Nat Biomed Eng. 2023 Mar;7(3):253-269. doi: 10.1038/s41551-022-00963-6. Epub 2022 Nov 24. PubMed PMID: 36424465.

select

Ni P, Fan L, Zinski A, Chung S. Generation of Homogeneous Populations of Cortical Interneurons from Human Pluripotent Stem Cells. Methods Mol Biol. 2023;2683:13-20. doi: 10.1007/978-1-0716-3287-1_2. PubMed PMID: 37300763.

select

Liu D, Zinski A, Mishra A, Noh H, Park GH, Qin Y, Olorife O, Park JM, Abani CP, Park JS, Fung J, Sawaqed F, Coyle JT, Stahl E, Bendl J, Fullard JF, Roussos P, Zhang X, Stanton PK, Yin C, Huang W, Kim HY, Won H, Cho JH, Chung S. Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development. Mol Psychiatry. 2022 Oct;27(10):4218-4233. doi: 10.1038/s41380-022-01654-z. Epub 2022 Jun 14. PubMed PMID: 35701597.

select

Ni P, Ma Y, Chung S. Mitochondrial dysfunction in psychiatric disorders. Schizophr Res. 2022 Sep 26;. doi: 10.1016/j.schres.2022.08.027. [Epub ahead of print] PubMed PMID: 36175250.

select

Datta D, Subburaju S, Kaye S, Baruah J, Choi YK, Nian Y, Khalili JS, Chung S, Elkhal A, Vasudevan A. Human forebrain endothelial cell therapy for psychiatric disorders. Mol Psychiatry. 2021 Sep;26(9):4864-4883. doi: 10.1038/s41380-020-0839-9. Epub 2020 Jul 13. PubMed PMID: 32661257; PubMed Central PMCID: PMC8162704.

select

Park JM, Liu D, Park GH, Noh H, Ni P, Yin C, Huang W, Chung S. Migratory cortical interneuron-specific transcriptome abnormalities in schizophrenia. J Psychiatr Res. 2021 May;137:111-116. doi: 10.1016/j.jpsychires.2021.02.054. Epub 2021 Feb 27. PubMed PMID: 33677214.

select

Ni P, Noh H, Park GH, Shao Z, Guan Y, Park JM, Yu S, Park JS, Coyle JT, Weinberger DR, Straub RE, Cohen BM, McPhie DL, Yin C, Huang W, Kim HY, Chung S. iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function. Mol Psychiatry. 2020 Nov;25(11):2873-2888. doi: 10.1038/s41380-019-0423-3. Epub 2019 Apr 24. PubMed PMID: 31019265; PubMed Central PMCID: PMC6813882.

select

Park GH, Noh H, Shao Z, Ni P, Qin Y, Liu D, Beaudreault CP, Park JS, Abani CP, Park JM, Le DT, Gonzalez SZ, Guan Y, Cohen BM, McPhie DL, Coyle JT, Lanz TA, Xi HS, Yin C, Huang W, Kim HY, Chung S. Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia. Nat Neurosci. 2020 Nov;23(11):1352-1364. doi: 10.1038/s41593-020-00724-1. Epub 2020 Oct 23. PubMed PMID: 33097921; PubMed Central PMCID: PMC7769122.

select

Ni P, Chung S. Mitochondrial Dysfunction in Schizophrenia. Bioessays. 2020 Jun;42(6):e1900202. doi: 10.1002/bies.201900202. Epub 2020 Apr 27. Review. PubMed PMID: 32338416.

select

Ni P, Noh H, Shao Z, Zhu Q, Guan Y, Park JJ, Arif F, Park JM, Abani C, Beaudreault C, Park JS, Berry E, Moghadam A, Stanton P, Hutchinson JN, Andrews B, Faux C, Parnevelas J, Eisenberg LM, Park K, Bolshakov VY, Chung S. Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells. Mol Ther Methods Clin Dev. 2019 Jun 14;13:414-430. doi: 10.1016/j.omtm.2019.04.002. eCollection 2019 Jun 14. PubMed PMID: 31061832; PubMed Central PMCID: PMC6495066.

select

Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, Berman KF, Apud J, Ongur D, Cohen BM, McPhie DL, Rapoport JL, Perlis RH, Lanz TA, Xi HS, Yin C, Huang W, Hirayama T, Fukuda E, Yagi T, Ghosh S, Eggan KC, Kim HY, Eisenberg LM, Moghadam AA, Stanton PK, Cho JH, Chung S. Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nat Neurosci. 2019 Feb;22(2):229-242. doi: 10.1038/s41593-018-0313-z. Epub 2019 Jan 21. PubMed PMID: 30664768; PubMed Central PMCID: PMC6373728.

select

Zhu Q, Naegele JR, Chung S. Cortical GABAergic Interneuron/Progenitor Transplantation as a Novel Therapy for Intractable Epilepsy. Front Cell Neurosci. 2018;12:167. doi: 10.3389/fncel.2018.00167. eCollection 2018. Review. PubMed PMID: 29997478; PubMed Central PMCID: PMC6028694.

select

Noh H, Shao Z, Coyle JT, Chung S. Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells (iPSCs). Biochim Biophys Acta Mol Basis Dis. 2017 Sep;1863(9):2382-2387. doi: 10.1016/j.bbadis.2017.06.019. Epub 2017 Jun 28. Review. PubMed PMID: 28668333; PubMed Central PMCID: PMC5737829.

select

Ahn S, Kim TG, Kim KS, Chung S. Differentiation of human pluripotent stem cells into Medial Ganglionic Eminence vs. Caudal Ganglionic Eminence cells. Methods. 2016 May 15;101:103-12. doi: 10.1016/j.ymeth.2015.09.009. Epub 2015 Sep 10. PubMed PMID: 26364591; PubMed Central PMCID: PMC4786472.

select

Leung A, Ahn S, Savvidis G, Kim Y, Iskandar D, Luna MJ, Kim KS, Cunningham M, Chung S. Optimization of pilocarpine-mediated seizure induction in immunodeficient NodScid mice. Epilepsy Res. 2015 Jan;109:114-8. doi: 10.1016/j.eplepsyres.2014.10.016. Epub 2014 Nov 6. PubMed PMID: 25524850; PubMed Central PMCID: PMC4273671.

select

Cunningham M, Cho JH, Leung A, Savvidis G, Ahn S, Moon M, Lee PK, Han JJ, Azimi N, Kim KS, Bolshakov VY, Chung S. hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell. 2014 Nov 6;15(5):559-73. doi: 10.1016/j.stem.2014.10.006. Epub 2014 Nov 6. PubMed PMID: 25517465; PubMed Central PMCID: PMC4270101.

select

Kim TG, Yao R, Monnell T, Cho JH, Vasudevan A, Koh A, Peeyush KT, Moon M, Datta D, Bolshakov VY, Kim KS, Chung S. Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudal modulation. Stem Cells. 2014 Jul;32(7):1789-804. doi: 10.1002/stem.1704. PubMed PMID: 24648391; PubMed Central PMCID: PMC4147720.

select

Hong S, Chung S, Leung K, Hwang I, Moon J, Kim KS. Functional roles of Nurr1, Pitx3, and Lmx1a in neurogenesis and phenotype specification of dopamine neurons during in vitro differentiation of embryonic stem cells. Stem Cells Dev. 2014 Mar 1;23(5):477-87. doi: 10.1089/scd.2013.0406. Epub 2013 Dec 4. PubMed PMID: 24172139; PubMed Central PMCID: PMC3928687.

select

Chung S, Moon J, Kim KS. Improvement of neurological dysfunctions in aphakia mice, a model of Parkinson's disease, after transplantation of ES cell-derived dopaminergic neuronal precursors. Methods Mol Biol. 2014;1213:285-91. doi: 10.1007/978-1-4939-1453-1_23. PubMed PMID: 25173391; PubMed Central PMCID: PMC4895918.

select

Moon J, Lee HS, Kang JM, Park J, Leung A, Hong S, Chung S, Kim KS. Stem cell grafting improves both motor and cognitive impairments in a genetic model of Parkinson's disease, the aphakia (ak) mouse. Cell Transplant. 2013;22(7):1263-79. doi: 10.3727/096368912X657242. Epub 2012 Oct 2. PubMed PMID: 23031199; PubMed Central PMCID: PMC3752607.

select

Chung S, Kim CH, Kim KS. Lmx1a regulates dopamine transporter gene expression during ES cell differentiation and mouse embryonic development. J Neurochem. 2012 Jul;122(2):244-50. doi: 10.1111/j.1471-4159.2012.07779.x. Epub 2012 May 23. PubMed PMID: 22564125; PubMed Central PMCID: PMC3421045.

select

Chung S, Moon JI, Leung A, Aldrich D, Lukianov S, Kitayama Y, Park S, Li Y, Bolshakov VY, Lamonerie T, Kim KS. ES cell-derived renewable and functional midbrain dopaminergic progenitors. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9703-8. doi: 10.1073/pnas.1016443108. Epub 2011 May 23. PubMed PMID: 21606375; PubMed Central PMCID: PMC3111266.

select

Chung S, Leung A, Han BS, Chang MY, Moon JI, Kim CH, Hong S, Pruszak J, Isacson O, Kim KS. Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell. 2009 Dec 4;5(6):646-58. doi: 10.1016/j.stem.2009.09.015. PubMed PMID: 19951692; PubMed Central PMCID: PMC2788512.

select

Chung S, Shin BS, Hedlund E, Pruszak J, Ferree A, Kang UJ, Isacson O, Kim KS. Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. J Neurochem. 2006 Jun;97(5):1467-80. doi: 10.1111/j.1471-4159.2006.03841.x. PubMed PMID: 16696855; PubMed Central PMCID: PMC2610439.

select

Chung S, Shin BS, Hwang M, Lardaro T, Kang UJ, Isacson O, Kim KS. Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro. Stem Cells. 2006 Jun;24(6):1583-93. doi: 10.1634/stemcells.2005-0558. Epub 2006 Mar 16. PubMed PMID: 16543488; PubMed Central PMCID: PMC2613224.

select

Kim DW, Chung S, Hwang M, Ferree A, Tsai HC, Park JJ, Chung S, Nam TS, Kang UJ, Isacson O, Kim KS. Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells. Stem Cells. 2006 Mar;24(3):557-67. doi: 10.1634/stemcells.2005-0233. Epub 2005 Aug 25. PubMed PMID: 16123386; PubMed Central PMCID: PMC2602800.

select

Chung S, Kim KS. Transfection and promoter analysis in embryonic stem cells. Methods Mol Biol. 2006;329:187-93. doi: 10.1385/1-59745-037-5:187. PubMed PMID: 16845992.

select

Lee YS, Kim HK, Chung S, Kim KS, Dutta A. Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation. J Biol Chem. 2005 Apr 29;280(17):16635-41. doi: 10.1074/jbc.M412247200. Epub 2005 Feb 18. PubMed PMID: 15722555.

select

Chung S, Hedlund E, Hwang M, Kim DW, Shin BS, Hwang DY, Kang UJ, Isacson O, Kim KS. The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons. Mol Cell Neurosci. 2005 Feb;28(2):241-52. doi: 10.1016/j.mcn.2004.09.008. PubMed PMID: 15691706; NIHMSID:NIHMS81637.

select

Kim KS, Kim CH, Hwang DY, Seo H, Chung S, Hong SJ, Lim JK, Anderson T, Isacson O. Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner. J Neurochem. 2003 May;85(3):622-34. doi: 10.1046/j.1471-4159.2003.01671.x. PubMed PMID: 12694388.

select

Chung S, Sonntag KC, Andersson T, Bjorklund LM, Park JJ, Kim DW, Kang UJ, Isacson O, Kim KS. Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. Eur J Neurosci. 2002 Nov;16(10):1829-38. doi: 10.1046/j.1460-9568.2002.02255.x. PubMed PMID: 12453046; PubMed Central PMCID: PMC2610444.

select

Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2344-9. doi: 10.1073/pnas.022438099. Epub 2002 Jan 8. PubMed PMID: 11782534; PubMed Central PMCID: PMC122367.

select

Chung S, Andersson T, Sonntag KC, Björklund L, Isacson O, Kim KS. Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines. Stem Cells. 2002;20(2):139-45. doi: 10.1634/stemcells.20-2-139. PubMed PMID: 11897870; PubMed Central PMCID: PMC2615228.

select

Isacson O, Costantini L, Schumacher JM, Cicchetti F, Chung S, Kim K. Cell implantation therapies for Parkinson's disease using neural stem, transgenic or xenogeneic donor cells. Parkinsonism Relat Disord. 2001 Jul;7(3):205-212. doi: 10.1016/s1353-8020(00)00059-6. PubMed PMID: 11331188.

select

Aranda-Abreu GE, Behar L, Chung S, Furneaux H, Ginzburg I. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells. J Neurosci. 1999 Aug 15;19(16):6907-17. doi: 10.1523/JNEUROSCI.19-16-06907.1999. PubMed PMID: 10436048; PubMed Central PMCID: PMC6782881.

select

Levy NS, Chung S, Furneaux H, Levy AP. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem. 1998 Mar 13;273(11):6417-23. doi: 10.1074/jbc.273.11.6417. PubMed PMID: 9497373.

select

Ma WJ, Chung S, Furneaux H. The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA. Nucleic Acids Res. 1997 Sep 15;25(18):3564-9. doi: 10.1093/nar/25.18.3564. PubMed PMID: 9278474; PubMed Central PMCID: PMC146929.

select

Chung S, Eckrich M, Perrone-Bizzozero N, Kohn DT, Furneaux H. The Elav-like proteins bind to a conserved regulatory element in the 3'-untranslated region of GAP-43 mRNA. J Biol Chem. 1997 Mar 7;272(10):6593-8. doi: 10.1074/jbc.272.10.6593. PubMed PMID: 9045688.

select

Chung S, Jiang L, Cheng S, Furneaux H. Purification and properties of HuD, a neuronal RNA-binding protein. J Biol Chem. 1996 May 10;271(19):11518-24. doi: 10.1074/jbc.271.19.11518. PubMed PMID: 8626712.