My Bibliography

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Jenkin D, Ritchie AJ, Aboagye J, Fedosyuk S, Thorley L, Provstgaad-Morys S, Sanders H, Bellamy D, Makinson R, Xiang ZQ, Bolam E, Tarrant R, Ramos Lopez F, Platt A, Poulton I, Green C, Ertl HCJ, Ewer KJ, Douglas AD. Safety and immunogenicity of a simian-adenovirus-vectored rabies vaccine: an open-label, non-randomised, dose-escalation, first-in-human, single-centre, phase 1 clinical trial. Lancet Microbe. 2022 Sep;3(9):e663-e671. doi: 10.1016/S2666-5247(22)00126-4. Epub 2022 Jul 27. PubMed PMID: 35907430; PubMed Central PMCID: PMC7614839.

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Ertl HCJ, Currie SL, Luber AD. Restricting use of adenovirus vector-based COVID vaccines could endanger public and global health. Front Immunol. 2022;13:985382. doi: 10.3389/fimmu.2022.985382. eCollection 2022. PubMed PMID: 36091063; PubMed Central PMCID: PMC9454295.

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Ertl HCJ. Immunogenicity and toxicity of AAV gene therapy. Front Immunol. 2022;13:975803. doi: 10.3389/fimmu.2022.975803. eCollection 2022. Review. PubMed PMID: 36032092; PubMed Central PMCID: PMC9411526.

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Herati RS, Knorr DA, Vella LA, Silva LV, Chilukuri L, Apostolidis SA, Huang AC, Muselman A, Manne S, Kuthuru O, Staupe RP, Adamski SA, Kannan S, Kurupati RK, Ertl HCJ, Wong JL, Bournazos S, McGettigan S, Schuchter LM, Kotecha RR, Funt SA, Voss MH, Motzer RJ, Lee CH, Bajorin DF, Mitchell TC, Ravetch JV, Wherry EJ. PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nat Immunol. 2022 Aug;23(8):1183-1192. doi: 10.1038/s41590-022-01274-3. Epub 2022 Jul 28. PubMed PMID: 35902637; PubMed Central PMCID: PMC9880663.

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Gehring AJ, Mendez P, Richter K, Ertl H, Donaldson EF, Mishra P, Maini M, Boonstra A, Lauer G, de Creus A, Whitaker K, Martinez SF, Weber J, Gainor E, Miller V. Immunological biomarker discovery in cure regimens for chronic hepatitis B virus infection. J Hepatol. 2022 Aug;77(2):525-538. doi: 10.1016/j.jhep.2022.02.020. Epub 2022 Mar 5. Review. PubMed PMID: 35259469.

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Ertl HCJ, Currie SL, Livermore DM. Back to the Future: Can Vaccines Win the Long-Term Fight Against COVID-19?. Front Public Health. 2022;10:929445. doi: 10.3389/fpubh.2022.929445. eCollection 2022. PubMed PMID: 35769785; PubMed Central PMCID: PMC9234198.

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Xiang Z, Kuranda K, Quinn W, Chekaoui A, Ambrose R, Hasanpourghai M, Novikov M, Newman D, Cole C, Zhou X, Mingozzi F, Ertl HCJ. The Effect of Rapamycin and Ibrutinib on Antibody Responses to Adeno-Associated Virus Vector-Mediated Gene Transfer. Hum Gene Ther. 2022 Jun;33(11-12):614-624. doi: 10.1089/hum.2021.258. Epub 2022 May 4. PubMed PMID: 35229644.

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Logunov DY, Livermore DM, Ornelles DA, Bayer W, Marques E, Czerkinsky C, Dolzhikova IV, Ertl HC. COVID-19 vaccination and HIV-1 acquisition. Lancet. 2022 Apr 9;399(10333):e34-e35. doi: 10.1016/S0140-6736(22)00332-4. PubMed PMID: 35397866; PubMed Central PMCID: PMC8989395.

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Knobel DL, Jackson AC, Bingham J, Ertl HCJ, Gibson AD, Hughes D, Joubert K, Mani RS, Mohr BJ, Moore SM, Rivett-Carnac H, Tordo N, Yeates JW, Zambelli AB, Rupprecht CE. A One Medicine Mission for an Effective Rabies Therapy. Front Vet Sci. 2022;9:867382. doi: 10.3389/fvets.2022.867382. eCollection 2022. PubMed PMID: 35372555; PubMed Central PMCID: PMC8967983.

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Hasanpourghadi M, Novikov M, Newman D, Xiang Z, Zhou XY, Magowan C, Ertl HCJ. Hepatitis B virus polymerase-specific T cell epitopes shift in a mouse model of chronic infection. Virol J. 2021 Dec 7;18(1):242. doi: 10.1186/s12985-021-01712-y. PubMed PMID: 34876153; PubMed Central PMCID: PMC8650432.

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Tietjen I, Cassel J, Register ET, Zhou XY, Messick TE, Keeney F, Lu LD, Beattie KD, Rali T, Tebas P, Ertl HCJ, Salvino JM, Davis RA, Montaner LJ. The Natural Stilbenoid (-)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0077221. doi: 10.1128/AAC.00772-21. Epub 2021 Sep 20. PubMed PMID: 34543092; PubMed Central PMCID: PMC8597786.

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Chekaoui A, Ertl HCJ. PPARα Agonist Fenofibrate Enhances Cancer Vaccine Efficacy. Cancer Res. 2021 Sep 1;81(17):4431-4440. doi: 10.1158/0008-5472.CAN-21-0052. Epub 2021 Jul 8. PubMed PMID: 34244236.

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Herati RS, Silva LV, Vella LA, Muselman A, Alanio C, Bengsch B, Kurupati RK, Kannan S, Manne S, Kossenkov AV, Canaday DH, Doyle SA, Ertl HCJ, Schmader KE, Wherry EJ. Vaccine-induced ICOS(+)CD38(+) circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways. Cell Rep Med. 2021 May 18;2(5):100262. doi: 10.1016/j.xcrm.2021.100262. eCollection 2021 May 18. PubMed PMID: 34095875; PubMed Central PMCID: PMC8149371.

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Hasanpourghadi M, Novikov M, Ertl HCJ. COVID-19 Vaccines Based on Adenovirus Vectors. Trends Biochem Sci. 2021 May;46(5):429-430. doi: 10.1016/j.tibs.2021.03.002. Epub 2021 Mar 14. Review. PubMed PMID: 33810926; PubMed Central PMCID: PMC7955943.

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Ertl HCJ. T Cell-Mediated Immune Responses to AAV and AAV Vectors. Front Immunol. 2021;12:666666. doi: 10.3389/fimmu.2021.666666. eCollection 2021. Review. PubMed PMID: 33927727; PubMed Central PMCID: PMC8076552.

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Hasanpourghadi M, Novikov M, Ambrose R, Chekaoui A, Newman D, Zhou XY, Ertl HCJ. T cell responses to adenoviral vectors expressing the SARS-CoV-2 nucleoprotein. Curr Trends Microbiol. 2021;15:1-28. PubMed PMID: 35903088; PubMed Central PMCID: PMC9328080.

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Xiang Z, Kurupati RK, Li Y, Kuranda K, Zhou X, Mingozzi F, High KA, Ertl HCJ. The Effect of CpG Sequences on Capsid-Specific CD8(+) T Cell Responses to AAV Vector Gene Transfer. Mol Ther. 2020 Mar 4;28(3):771-783. doi: 10.1016/j.ymthe.2019.11.014. Epub 2019 Nov 21. PubMed PMID: 31839483; PubMed Central PMCID: PMC7054717.

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Rupprecht CE, Abela-Ridder B, Abila R, Amparo AC, Banyard A, Blanton J, Chanachai K, Dallmeier K, de Balogh K, Del Rio Vilas V, Ertl H, Freuling C, Hill R, Houillon G, Jakava-Viljanen M, Kasemsuwan S, Léchenet J, Nel L, Panichabhongse P, Rahman SA, Tantawichien T, Vandeputte J, Viriyabancha W, Vos A, Wallace R, Yale G, Yurachai O, Mueller T. Towards rabies elimination in the Asia-Pacific region: From theory to practice. Biologicals. 2020 Mar;64:83-95. doi: 10.1016/j.biologicals.2020.01.008. Epub 2020 Feb 20. PubMed PMID: 32089431.

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Fooks AR, Banyard AC, Ertl HCJ. New human rabies vaccines in the pipeline. Vaccine. 2019 Oct 3;37 Suppl 1(Suppl 1):A140-A145. doi: 10.1016/j.vaccine.2018.08.039. Epub 2018 Aug 25. Review. PubMed PMID: 30153997; PubMed Central PMCID: PMC6863069.

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Ertl HCJ. Preclinical models to assess the immunogenicity of AAV vectors. Cell Immunol. 2019 Aug;342:103722. doi: 10.1016/j.cellimm.2017.11.006. Epub 2017 Nov 23. PubMed PMID: 29195742.

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Kurupati RK, Haut LH, Schmader KE, Ertl HC. Age-related changes in B cell metabolism. Aging (Albany NY). 2019 Jul 8;11(13):4367-4381. doi: 10.18632/aging.102058. PubMed PMID: 31283526; PubMed Central PMCID: PMC6660053.

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Ertl HCJ. New Rabies Vaccines for Use in Humans. Vaccines (Basel). 2019 Jun 20;7(2). doi: 10.3390/vaccines7020054. Review. PubMed PMID: 31226750; PubMed Central PMCID: PMC6631309.

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Taylor E, Banyard AC, Bourhy H, Cliquet F, Ertl H, Fehlner-Gardiner C, Horton DL, Mani RS, Müller T, Rupprecht CE, Schnell MJ, Del Rio Vilas V, Fooks AR. Avoiding preventable deaths: The scourge of counterfeit rabies vaccines. Vaccine. 2019 Apr 17;37(17):2285-2287. doi: 10.1016/j.vaccine.2019.03.037. Epub 2019 Mar 25. PubMed PMID: 30922698.

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Henry C, Zheng NY, Huang M, Cabanov A, Rojas KT, Kaur K, Andrews SF, Palm AE, Chen YQ, Li Y, Hoskova K, Utset HA, Vieira MC, Wrammert J, Ahmed R, Holden-Wiltse J, Topham DJ, Treanor JJ, Ertl HC, Schmader KE, Cobey S, Krammer F, Hensley SE, Greenberg H, He XS, Wilson PC. Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. Cell Host Microbe. 2019 Mar 13;25(3):357-366.e6. doi: 10.1016/j.chom.2019.01.002. Epub 2019 Feb 19. PubMed PMID: 30795982; PubMed Central PMCID: PMC6452894.

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Kurupati R, Ertl HC. Coaching tumor-infiltrating CD8+ T cells to eat right. Oncoscience. 2018 Nov;5(11-12):276-277. doi: 10.18632/oncoscience.466. eCollection 2018 Nov. PubMed PMID: 30652112; PubMed Central PMCID: PMC6326734.

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Wang C, Dulal P, Zhou X, Xiang Z, Goharriz H, Banyard A, Green N, Brunner L, Ventura R, Collin N, Draper SJ, Hill AVS, Ashfield R, Fooks AR, Ertl HC, Douglas AD. A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis. PLoS Negl Trop Dis. 2018 Oct;12(10):e0006870. doi: 10.1371/journal.pntd.0006870. eCollection 2018 Oct. PubMed PMID: 30372438; PubMed Central PMCID: PMC6224154.

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Kurupati RK, Zhou X, Xiang Z, Keller LH, Ertl HCJ. Safety and immunogenicity of a potential checkpoint blockade vaccine for canine melanoma. Cancer Immunol Immunother. 2018 Oct;67(10):1533-1544. doi: 10.1007/s00262-018-2201-5. Epub 2018 Jul 26. PubMed PMID: 30051333; PubMed Central PMCID: PMC7080056.

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Agarwal D, Schmader KE, Kossenkov AV, Doyle S, Kurupati R, Ertl HCJ. Immune response to influenza vaccination in the elderly is altered by chronic medication use. Immun Ageing. 2018;15:19. doi: 10.1186/s12979-018-0124-9. eCollection 2018. PubMed PMID: 30186359; PubMed Central PMCID: PMC6119322.

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Ertl HCJ. Human immune responses to traditional and novel rabies vaccines. Rev Sci Tech. 2018 Aug;37(2):649-656. doi: 10.20506/rst.37.2.2830. PubMed PMID: 30747120.

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Rupprecht CE, Xiang Z, Servat A, Franka R, Kirby J, Ertl HCJ. Erratum: Rupprecht, C.E., et al. Additional Progress in the Development and Application of a Direct, Rapid Immunohistochemical Test for Rabies Diagnosis. Vet. Sci. 2018, 5, 59. Vet Sci. 2018 Jul 20;5(3). doi: 10.3390/vetsci5030068. PubMed PMID: 30036969; PubMed Central PMCID: PMC6165155.

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Cobey S, Gouma S, Parkhouse K, Chambers BS, Ertl HC, Schmader KE, Halpin RA, Lin X, Stockwell TB, Das SR, Landon E, Tesic V, Youngster I, Pinsky BA, Wentworth DE, Hensley SE, Grad YH. Poor Immunogenicity, Not Vaccine Strain Egg Adaptation, May Explain the Low H3N2 Influenza Vaccine Effectiveness in 2012-2013. Clin Infect Dis. 2018 Jul 18;67(3):327-333. doi: 10.1093/cid/ciy097. PubMed PMID: 29471464; PubMed Central PMCID: PMC6051447.

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Rupprecht CE, Xiang Z, Servat A, Franka R, Kirby J, Ertl HCJ. Additional Progress in the Development and Application of a Direct, Rapid Immunohistochemical Test for Rabies Diagnosis. Vet Sci. 2018 Jun 20;5(2). doi: 10.3390/vetsci5020059. PubMed PMID: 29925781; PubMed Central PMCID: PMC6024515.

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Tuyishime S, Haut LH, Kurupati RK, Billingsley JM, Carnathan D, Gangahara S, Styles TM, Xiang Z, Li Y, Zopfs M, Liu Q, Zhou X, Lewis MG, Amara RR, Bosinger S, Silvestri G, Ertl HCJ. Correlates of Protection Against SIV(mac251) Infection in Rhesus Macaques Immunized With Chimpanzee-Derived Adenovirus Vectors. EBioMedicine. 2018 May;31:25-35. doi: 10.1016/j.ebiom.2018.02.025. Epub 2018 Mar 4. PubMed PMID: 29685793; PubMed Central PMCID: PMC6013748.

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Kurupati R, Ertl HC. Coaching tumor-infiltrating CD8(+) T cells to eat right. Oncoscience. 2018 Jan;5(1-2):1-2. doi: 10.18632/oncoscience.390. eCollection 2018 Jan. PubMed PMID: 29556509; PubMed Central PMCID: PMC5854284.

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Zhang Y, Kurupati R, Liu L, Zhou XY, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis GC, Schuchter LM, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman GJ, Rabinowitz JD, Ertl HCJ. Enhancing CD8(+) T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell. 2017 Sep 11;32(3):377-391.e9. doi: 10.1016/j.ccell.2017.08.004. PubMed PMID: 28898698; PubMed Central PMCID: PMC5751418.

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Kurupati RK, Kossenkoff A, Kannan S, Haut LH, Doyle S, Yin X, Schmader KE, Liu Q, Showe L, Ertl HCJ. The effect of timing of influenza vaccination and sample collection on antibody titers and responses in the aged. Vaccine. 2017 Jun 27;35(30):3700-3708. doi: 10.1016/j.vaccine.2017.05.074. Epub 2017 Jun 2. PubMed PMID: 28583307.

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Afkhami S, LeClair DA, Haddadi S, Lai R, Toniolo SP, Ertl HC, Cranston ED, Thompson MR, Xing Z. Spray dried human and chimpanzee adenoviral-vectored vaccines are thermally stable and immunogenic in vivo. Vaccine. 2017 May 19;35(22):2916-2924. doi: 10.1016/j.vaccine.2017.04.026. Epub 2017 Apr 21. PubMed PMID: 28438408.

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Ertl HCJ, High KA. Impact of AAV Capsid-Specific T-Cell Responses on Design and Outcome of Clinical Gene Transfer Trials with Recombinant Adeno-Associated Viral Vectors: An Evolving Controversy. Hum Gene Ther. 2017 Apr;28(4):328-337. doi: 10.1089/hum.2016.172. Epub 2016 Dec 29. PubMed PMID: 28042943.

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Dawany N, Parzych EM, Showe LC, Ertl HC. Age-related changes in the gene expression profile of antigen-specific mouse CD8+ T cells can be partially reversed by blockade of the BTLA/CD160 pathways during vaccination. Aging (Albany NY). 2016 Nov 9;8(12):3272-3297. doi: 10.18632/aging.101105. PubMed PMID: 27922818; PubMed Central PMCID: PMC5270668.

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Emmer KL, Wieczorek L, Tuyishime S, Molnar S, Polonis VR, Ertl HC. Antibody responses to prime-boost vaccination with an HIV-1 gp145 envelope protein and chimpanzee adenovirus vectors expressing HIV-1 gp140. AIDS. 2016 Oct 23;30(16):2405-2414. doi: 10.1097/QAD.0000000000001224. PubMed PMID: 27525550; PubMed Central PMCID: PMC5069158.

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Zhang Y, Ertl HC. Aging: T cell metabolism within tumors. Aging (Albany NY). 2016 Jun;8(6):1163-4. doi: 10.18632/aging.100979. PubMed PMID: 27282177; PubMed Central PMCID: PMC4931823.

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Zhang Y, Ertl HC. Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors. Oncotarget. 2016 Apr 26;7(17):23282-99. doi: 10.18632/oncotarget.7818. PubMed PMID: 26943036; PubMed Central PMCID: PMC5029626.

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Zhang Y, Ertl HC. Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor Progression. Front Immunol. 2016;7:32. doi: 10.3389/fimmu.2016.00032. eCollection 2016. Review. PubMed PMID: 26904023; PubMed Central PMCID: PMC4748049.

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Kannan S, Kossenkov A, Kurupati RK, Xiang JZ, Doyle SA, Schmader KE, Schowe L, Ertl HC. A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged. Aging (Albany NY). 2015 Dec;7(12):1077-85. doi: 10.18632/aging.100852. PubMed PMID: 26637961; PubMed Central PMCID: PMC4712333.

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Kannan S, Kurupati RK, Doyle SA, Freeman GJ, Schmader KE, Ertl HC. BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine. Oncotarget. 2015 Aug 14;6(23):19445-55. doi: 10.18632/oncotarget.4597. PubMed PMID: 26277622; PubMed Central PMCID: PMC4637297.

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Small JC, Haut LH, Bian A, Ertl HC. The effect of adenovirus-specific antibodies on adenoviral vector-induced, transgene product-specific T cell responses. J Leukoc Biol. 2014 Nov;96(5):821-31. doi: 10.1189/jlb.1A0813-451RR. Epub 2014 Jul 31. PubMed PMID: 25082150; PubMed Central PMCID: PMC4197559.

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Herati RS, Reuter MA, Dolfi DV, Mansfield KD, Aung H, Badwan OZ, Kurupati RK, Kannan S, Ertl H, Schmader KE, Betts MR, Canaday DH, Wherry EJ. Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults. J Immunol. 2014 Oct 1;193(7):3528-37. doi: 10.4049/jimmunol.1302503. Epub 2014 Aug 29. PubMed PMID: 25172499; PubMed Central PMCID: PMC4170011.

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Zhang Y, Ertl HC. The effect of adjuvanting cancer vaccines with herpes simplex virus glycoprotein D on melanoma-driven CD8+ T cell exhaustion. J Immunol. 2014 Aug 15;193(4):1836-46. doi: 10.4049/jimmunol.1302029. Epub 2014 Jul 14. PubMed PMID: 25024391; PubMed Central PMCID: PMC4254702.

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Tuyishime S, Haut LH, Zhu C, Ertl HC. Enhancement of recombinant adenovirus vaccine-induced primary but not secondary systemic and mucosal immune responses by all-trans retinoic acid. Vaccine. 2014 Jun 5;32(27):3386-92. doi: 10.1016/j.vaccine.2014.04.028. Epub 2014 Apr 26. PubMed PMID: 24780251; PubMed Central PMCID: PMC4219370.

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Leskowitz R, Fogg MH, Zhou XY, Kaur A, Silveira EL, Villinger F, Lieberman PM, Wang F, Ertl HC. Adenovirus-based vaccines against rhesus lymphocryptovirus EBNA-1 induce expansion of specific CD8+ and CD4+ T cells in persistently infected rhesus macaques. J Virol. 2014 May;88(9):4721-35. doi: 10.1128/JVI.03744-13. Epub 2014 Feb 12. PubMed PMID: 24522914; PubMed Central PMCID: PMC3993789.