My Bibliography

select

Garg R, Blando JM, Perez CJ, Lal P, Feldman MD, Smyth EM, Ricciotti E, Grosser T, Benavides F, Kazanietz MG. COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer. Oncogene. 2018 Aug;37(34):4735-4749. doi: 10.1038/s41388-018-0318-9. Epub 2018 May 16. PubMed PMID: 29765153; PubMed Central PMCID: PMC6195867.

select

Siangjong L, Goldman DH, Kriska T, Gauthier KM, Smyth EM, Puli N, Kumar G, Falck JR, Campbell WB. Vascular hepoxilin and trioxilins mediate vasorelaxation through TP receptor inhibition in mouse arteries. Acta Physiol (Oxf). 2017 Jan;219(1):188-201. doi: 10.1111/apha.12642. Epub 2016 Jan 4. PubMed PMID: 26666460; PubMed Central PMCID: PMC4909587.

select

Chen EP, Markosyan N, Connolly E, Lawson JA, Li X, Grant GR, Grosser T, FitzGerald GA, Smyth EM. Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function. Carcinogenesis. 2014 Aug;35(8):1788-97. doi: 10.1093/carcin/bgu053. Epub 2014 Mar 3. PubMed PMID: 24590894; PubMed Central PMCID: PMC4123643.

select

Khan A, Li D, Ibrahim S, Smyth E, Woulfe DS. The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated Akt activation. Mol Pharmacol. 2014 Jul;86(1):1-11. doi: 10.1124/mol.114.091595. Epub 2014 Apr 10. PubMed PMID: 24723492; PubMed Central PMCID: PMC4054002.

select

Markosyan N, Chen EP, Smyth EM. Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance. Oncoimmunology. 2014;3:e29287. doi: 10.4161/onci.29287. eCollection 2014. PubMed PMID: 25114833; PubMed Central PMCID: PMC4126836.

select

Frey AJ, Ibrahim S, Gleim S, Hwa J, Smyth EM. Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif. J Lipid Res. 2013 Jun;54(6):1678-1690. doi: 10.1194/jlr.M036673. Epub 2013 Mar 14. PubMed PMID: 23493750; PubMed Central PMCID: PMC3646468.

select

Siangjong L, Gauthier KM, Pfister SL, Smyth EM, Campbell WB. Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries. Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H382-92. doi: 10.1152/ajpheart.00690.2012. Epub 2012 Nov 30. PubMed PMID: 23203967; PubMed Central PMCID: PMC3774504.

select

Markosyan N, Chen EP, Evans RA, Ndong V, Vonderheide RH, Smyth EM. Mammary carcinoma cell derived cyclooxygenase 2 suppresses tumor immune surveillance by enhancing intratumoral immune checkpoint activity. Breast Cancer Res. 2013;15(5):R75. doi: 10.1186/bcr3469. PubMed PMID: 24004819; PubMed Central PMCID: PMC3979159.

select

Ibrahim S, McCartney A, Markosyan N, Smyth EM. Heterodimerization with the prostacyclin receptor triggers thromboxane receptor relocation to lipid rafts. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):60-6. doi: 10.1161/ATVBAHA.112.300536. Epub 2012 Nov 15. PubMed PMID: 23162015; PubMed Central PMCID: PMC3533363.

select

Chen EP, Smyth EM. COX-2 and PGE2-dependent immunomodulation in breast cancer. Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):14-20. doi: 10.1016/j.prostaglandins.2011.08.005. Epub 2011 Aug 31. Review. PubMed PMID: 21907301; PubMed Central PMCID: PMC4031099.

select

Markosyan N, Chen EP, Ndong VN, Yao Y, Sterner CJ, Chodosh LA, Lawson JA, Fitzgerald GA, Smyth EM. Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors. Carcinogenesis. 2011 Oct;32(10):1441-9. doi: 10.1093/carcin/bgr134. Epub 2011 Jul 18. PubMed PMID: 21771729; PubMed Central PMCID: PMC3975167.

select

Ibrahim S, Tetruashvily M, Frey AJ, Wilson SJ, Stitham J, Hwa J, Smyth EM. Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1802-9. doi: 10.1161/ATVBAHA.110.208900. Epub 2010 Jun 3. PubMed PMID: 20522800; PubMed Central PMCID: PMC2924460.

select

Smyth EM. Thromboxane and the thromboxane receptor in cardiovascular disease. Clin Lipidol. 2010 Apr 1;5(2):209-219. doi: 10.2217/clp.10.11. PubMed PMID: 20543887; PubMed Central PMCID: PMC2882156.

select

Yu Y, Stubbe J, Ibrahim S, Song WL, Smyth EM, Funk CD, FitzGerald GA. Cyclooxygenase-2-dependent prostacyclin formation and blood pressure homeostasis: targeted exchange of cyclooxygenase isoforms in mice. Circ Res. 2010 Feb 5;106(2):337-45. doi: 10.1161/CIRCRESAHA.109.204529. Epub 2009 Nov 25. PubMed PMID: 19940265; PubMed Central PMCID: PMC2818801.

select

McGillicuddy FC, Chiquoine EH, Hinkle CC, Kim RJ, Shah R, Roche HM, Smyth EM, Reilly MP. Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J Biol Chem. 2009 Nov 13;284(46):31936-44. doi: 10.1074/jbc.M109.061655. Epub 2009 Sep 23. PubMed PMID: 19776010; PubMed Central PMCID: PMC2797265.

select

Wilson SJ, Cavanagh CC, Lesher AM, Frey AJ, Russell SE, Smyth EM. Activation-dependent stabilization of the human thromboxane receptor: role of reactive oxygen species. J Lipid Res. 2009 Jun;50(6):1047-56. doi: 10.1194/jlr.M800447-JLR200. Epub 2009 Jan 16. PubMed PMID: 19151335; PubMed Central PMCID: PMC2681387.

select

Yu Y, Lucitt MB, Stubbe J, Cheng Y, Friis UG, Hansen PB, Jensen BL, Smyth EM, FitzGerald GA. Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7985-90. doi: 10.1073/pnas.0811834106. Epub 2009 Apr 24. PubMed PMID: 19416858; PubMed Central PMCID: PMC2673134.

select

Smyth EM, Grosser T, Wang M, Yu Y, FitzGerald GA. Prostanoids in health and disease. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S423-8. doi: 10.1194/jlr.R800094-JLR200. Epub 2008 Dec 17. Review. PubMed PMID: 19095631; PubMed Central PMCID: PMC2674745.

select

Wada M, DeLong CJ, Hong YH, Rieke CJ, Song I, Sidhu RS, Yuan C, Warnock M, Schmaier AH, Yokoyama C, Smyth EM, Wilson SJ, FitzGerald GA, Garavito RM, Sui de X, Regan JW, Smith WL. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem. 2007 Aug 3;282(31):22254-66. doi: 10.1074/jbc.M703169200. Epub 2007 May 22. PubMed PMID: 17519235.

select

Wilson SJ, Dowling JK, Zhao L, Carnish E, Smyth EM. Regulation of thromboxane receptor trafficking through the prostacyclin receptor in vascular smooth muscle cells: role of receptor heterodimerization. Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):290-6. doi: 10.1161/01.ATV.0000252667.53790.4e. Epub 2006 Nov 16. PubMed PMID: 17110599.

select

Wilson SJ, McGinley K, Huang AJ, Smyth EM. Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signaling. Biochem Biophys Res Commun. 2007 Jan 12;352(2):397-403. doi: 10.1016/j.bbrc.2006.11.040. Epub 2006 Nov 16. PubMed PMID: 17134677; PubMed Central PMCID: PMC1766557.

select

Wilson SJ, Smyth EM. Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6. J Biol Chem. 2006 Apr 28;281(17):11780-6. doi: 10.1074/jbc.M513110200. Epub 2006 Mar 9. PubMed PMID: 16527812.

select

Zhang L, DiLizio C, Kim D, Smyth EM, Manning DR. The G12 family of G proteins as a reporter of thromboxane A2 receptor activity. Mol Pharmacol. 2006 Apr;69(4):1433-40. doi: 10.1124/mol.105.019703. Epub 2006 Jan 17. PubMed PMID: 16418336; NIHMSID:NIHMS22370.

select

Wilson SJ, Roche AM, Kostetskaia E, Smyth EM. Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation. J Biol Chem. 2004 Dec 17;279(51):53036-47. doi: 10.1074/jbc.M405002200. Epub 2004 Oct 7. PubMed PMID: 15471868.

select

Egan KM, Lawson JA, Fries S, Koller B, Rader DJ, Smyth EM, Fitzgerald GA. COX-2-derived prostacyclin confers atheroprotection on female mice. Science. 2004 Dec 10;306(5703):1954-7. doi: 10.1126/science.1103333. Epub 2004 Nov 18. PubMed PMID: 15550624.

select

Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P. Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem. 2004 Feb 20;279(8):7091-7. doi: 10.1074/jbc.M311973200. Epub 2003 Nov 26. PubMed PMID: 14645221.

select

Kothapalli D, Stewart SA, Smyth EM, Azonobi I, Pure E, Assoian RK. Prostacylin receptor activation inhibits proliferation of aortic smooth muscle cells by regulating cAMP response element-binding protein- and pocket protein-dependent cyclin a gene expression. Mol Pharmacol. 2003 Aug;64(2):249-58. doi: 10.1124/mol.64.2.249. PubMed PMID: 12869629.

select

Smyth EM, Austin SC, FitzGerald GA. Activation-dependent internalization of the human prostacyclin receptor. Adv Exp Med Biol. 2002;507:295-301. doi: 10.1007/978-1-4615-0193-0_45. PubMed PMID: 12664600.

select

Smyth EM, FitzGerald GA. Human prostacyclin receptor. Vitam Horm. 2002;65:149-65. doi: 10.1016/s0083-6729(02)65063-0. Review. PubMed PMID: 12481546.

select

Zhang Z, Austin SC, Smyth EM. Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction. Mol Pharmacol. 2001 Sep;60(3):480-7. PubMed PMID: 11502878.

select

Smyth EM, Austin SC, Reilly MP, FitzGerald GA. Internalization and sequestration of the human prostacyclin receptor. J Biol Chem. 2000 Oct 13;275(41):32037-45. doi: 10.1074/jbc.M003873200. PubMed PMID: 10889200.

select

Smyth EM, Li WH, FitzGerald GA. Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c. J Biol Chem. 1998 Sep 4;273(36):23258-66. doi: 10.1074/jbc.273.36.23258. PubMed PMID: 9722557.

select

Smyth EM, Nestor PV, FitzGerald GA. Agonist-dependent phosphorylation of an epitope-tagged human prostacyclin receptor. J Biol Chem. 1996 Dec 27;271(52):33698-704. doi: 10.1074/jbc.271.52.33698. PubMed PMID: 8969241.

select

McQuaid KE, Smyth EM, Keenan AK. Evidence for modulation of hydrogen peroxide-induced endothelial barrier dysfunction by nitric oxide in vitro. Eur J Pharmacol. 1996 Jun 27;307(2):233-41. doi: 10.1016/0014-2999(96)00271-3. PubMed PMID: 8832226.

select

Praticò D, Smyth EM, Violi F, FitzGerald GA. Local amplification of platelet function by 8-Epi prostaglandin F2alpha is not mediated by thromboxane receptor isoforms. J Biol Chem. 1996 Jun 21;271(25):14916-24. doi: 10.1074/jbc.271.25.14916. PubMed PMID: 8663015.

select

Smyth EM, Keenan AK. The vascular ANF-C receptor: role in atrial peptide signalling. Cell Signal. 1994 Feb;6(2):125-33. doi: 10.1016/0898-6568(94)90068-x. Review. PubMed PMID: 8086274.

select

Smyth EM, Keenan AK. Effects of the ANF-C receptor ligand des[Cys105,Cys121]rANF(104-126) on ANF internalization and cGMP production by bovine pulmonary artery endothelial cells. Life Sci. 1994;54(1):1-7. doi: 10.1016/0024-3205(94)00571-0. PubMed PMID: 8255164.