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DRAZEN RAUCHER's Bibliography

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Dragojevic S, Ryu JS, Hall ME, Raucher D. Targeted Drug Delivery Biopolymers Effectively Inhibit Breast Tumor Growth and Prevent Doxorubicin-Induced Cardiotoxicity. Molecules. 2022 May 24;27(11). doi: 10.3390/molecules27113371. PubMed PMID: 35684309; PubMed Central PMCID: PMC9182553.

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Dragojevic S, Turner L, Raucher D. Circumventing Doxorubicin Resistance Using Elastin-like Polypeptide Biopolymer-Mediated Drug Delivery. Int J Mol Sci. 2022 Feb 19;23(4). doi: 10.3390/ijms23042301. PubMed PMID: 35216417; PubMed Central PMCID: PMC8878013.

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Thomas E, Dragojevic S, Price A, Raucher D. Thermally Targeted p50 Peptide Inhibits Proliferation and Induces Apoptosis of Breast Cancer Cell Lines. Macromol Biosci. 2020 Oct;20(10):e2000170. doi: 10.1002/mabi.202000170. Epub 2020 Jul 30. PubMed PMID: 32734662; PubMed Central PMCID: PMC7737380.

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Das P, Boone S, Mitra D, Turner L, Tandon R, Raucher D, Hamme AT 2nd. Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents. RSC Adv. 2020 Aug 10;10(50):30223-30237. doi: 10.1039/d0ra06148d. eCollection 2020 Aug 10. PubMed PMID: 35518245; PubMed Central PMCID: PMC9056317.

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Dragojevic S, Mackey R, Raucher D. Evaluation of Elastin-Like Polypeptides for Tumor Targeted Delivery of Doxorubicin to Glioblastoma. Molecules. 2019 Sep 6;24(18). doi: 10.3390/molecules24183242. PubMed PMID: 31489879; PubMed Central PMCID: PMC6767252.

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Raucher D. Tumor targeting peptides: novel therapeutic strategies in glioblastoma. Curr Opin Pharmacol. 2019 Aug;47:14-19. doi: 10.1016/j.coph.2019.01.006. Epub 2019 Feb 15. Review. PubMed PMID: 30776641; PubMed Central PMCID: PMC7288394.

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Das P, Hasan MH, Mitra D, Bollavarapu R, Valente EJ, Tandon R, Raucher D, Hamme AT 2nd. Design, Synthesis, and Preliminary Studies of Spiro-isoxazoline-peroxides against Human Cytomegalovirus and Glioblastoma ∥. J Org Chem. 2019 Jun 7;84(11):6992-7006. doi: 10.1021/acs.joc.9b00746. Epub 2019 May 17. PubMed PMID: 31066280.

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Opačak-Bernardi T, Ryu JS, Raucher D. Effects of cell penetrating Notch inhibitory peptide conjugated to elastin-like polypeptide on glioblastoma cells. J Drug Target. 2017 Jul;25(6):523-531. doi: 10.1080/1061186X.2017.1289537. Epub 2017 Feb 23. PubMed PMID: 28140690.

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Dragojevic S, Ryu JS, Raucher D. Polymer-Based Prodrugs: Improving Tumor Targeting and the Solubility of Small Molecule Drugs in Cancer Therapy. Molecules. 2015 Dec 4;20(12):21750-69. doi: 10.3390/molecules201219804. Review. PubMed PMID: 26690101; PubMed Central PMCID: PMC6331894.

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Raucher D, Ryu JS. Cell-penetrating peptides: strategies for anticancer treatment. Trends Mol Med. 2015 Sep;21(9):560-70. doi: 10.1016/j.molmed.2015.06.005. Epub 2015 Jul 15. Review. PubMed PMID: 26186888.

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Ryu JS, Raucher D. Elastin-like polypeptide for improved drug delivery for anticancer therapy: preclinical studies and future applications. Expert Opin Drug Deliv. 2015 Apr;12(4):653-67. doi: 10.1517/17425247.2015.974546. Epub 2014 Oct 28. Review. PubMed PMID: 25350837.

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Das P, Omollo AO, Sitole LJ, McClendon E, Valente EJ, Raucher D, Walker LR, Hamme AT 2nd. Synthesis and Investigation of Novel Spiro-isoxazolines as Anti-Cancer Agents. Tetrahedron Lett. 2015 Apr 1;56(14):1794-1797. doi: 10.1016/j.tetlet.2015.02.059. PubMed PMID: 25821250; PubMed Central PMCID: PMC4371604.

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Walker LR, Ryu JS, Perkins E, McNally LR, Raucher D. Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer. Drug Des Devel Ther. 2014;8:1649-58. doi: 10.2147/DDDT.S60451. eCollection 2014. PubMed PMID: 25336913; PubMed Central PMCID: PMC4199967.

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Hearst SM, Shao Q, Lopez M, Raucher D, Vig PJ. The design and delivery of a PKA inhibitory polypeptide to treat SCA1. J Neurochem. 2014 Oct;131(1):101-14. doi: 10.1111/jnc.12782. Epub 2014 Jun 23. PubMed PMID: 24903464.

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Hearst SM, Shao Q, Lopez M, Raucher D, Vig PJ. Focused cerebellar laser light induced hyperthermia improves symptoms and pathology of polyglutamine disease SCA1 in a mouse model. Cerebellum. 2014 Oct;13(5):596-606. doi: 10.1007/s12311-014-0576-1. PubMed PMID: 24930030.

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Ryu JS, Raucher D. Elastin-like polypeptides: the influence of its molecular weight on local hyperthermia-induced tumor accumulation. Eur J Pharm Biopharm. 2014 Oct;88(2):382-9. doi: 10.1016/j.ejpb.2014.05.016. Epub 2014 May 24. PubMed PMID: 24866938; NIHMSID:NIHMS599216.

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Ryu JS, Raucher D. Anti-tumor efficacy of a therapeutic peptide based on thermo-responsive elastin-like polypeptide in combination with gemcitabine. Cancer Lett. 2014 Jun 28;348(1-2):177-84. doi: 10.1016/j.canlet.2014.03.021. Epub 2014 Mar 26. PubMed PMID: 24680816.

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Ryu JS, Kuna M, Raucher D. Penetrating the cell membrane, thermal targeting and novel anticancer drugs: the development of thermally targeted, elastin-like polypeptide cancer therapeutics. Ther Deliv. 2014 Apr;5(4):429-45. doi: 10.4155/tde.14.14. Review. PubMed PMID: 24856169.

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Lyons DF, Le V, Kramer WH, Bidwell GL 3rd, Lewis EA, Raucher D, Correia JJ. Effect of basic cell-penetrating peptides on the structural, thermodynamic, and hydrodynamic properties of a novel drug delivery vector, ELP[V5G3A2-150]. Biochemistry. 2014 Feb 18;53(6):1081-91. doi: 10.1021/bi400955w. Epub 2014 Feb 4. PubMed PMID: 24450599; PubMed Central PMCID: PMC3985474.

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Mikecin AM, Walker LR, Kuna M, Raucher D. Thermally targeted p21 peptide enhances bortezomib cytotoxicity in androgen-independent prostate cancer cell lines. Anticancer Drugs. 2014 Feb;25(2):189-99. doi: 10.1097/CAD.0000000000000036. PubMed PMID: 24113592; PubMed Central PMCID: PMC3915535.

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Lyons DF, Le V, Bidwell GL 3rd, Kramer WH, Lewis EA, Raucher D, Correia JJ. Structural and hydrodynamic analysis of a novel drug delivery vector: ELP[V5G3A2-150]. Biophys J. 2013 May 7;104(9):2009-21. doi: 10.1016/j.bpj.2013.03.040. PubMed PMID: 23663844; PubMed Central PMCID: PMC3647178.

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Bidwell GL 3rd, Perkins E, Hughes J, Khan M, James JR, Raucher D. Thermally targeted delivery of a c-Myc inhibitory polypeptide inhibits tumor progression and extends survival in a rat glioma model. PLoS One. 2013;8(1):e55104. doi: 10.1371/journal.pone.0055104. Epub 2013 Jan 25. PubMed PMID: 23372821; PubMed Central PMCID: PMC3555869.

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Walker L, Perkins E, Kratz F, Raucher D. Cell penetrating peptides fused to a thermally targeted biopolymer drug carrier improve the delivery and antitumor efficacy of an acid-sensitive doxorubicin derivative. Int J Pharm. 2012 Oct 15;436(1-2):825-32. doi: 10.1016/j.ijpharm.2012.07.043. Epub 2012 Jul 28. PubMed PMID: 22850291; PubMed Central PMCID: PMC3465682.

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Moktan S, Raucher D. Anticancer activity of proapoptotic peptides is highly improved by thermal targeting using elastin-like polypeptides. Int J Pept Res Ther. 2012 Sep;18(3):227-237. doi: 10.1007/s10989-012-9295-y. PubMed PMID: 23105921; PubMed Central PMCID: PMC3480076.

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Moktan S, Perkins E, Kratz F, Raucher D. Thermal targeting of an acid-sensitive doxorubicin conjugate of elastin-like polypeptide enhances the therapeutic efficacy compared with the parent compound in vivo. Mol Cancer Ther. 2012 Jul;11(7):1547-56. doi: 10.1158/1535-7163.MCT-11-0998. Epub 2012 Apr 24. PubMed PMID: 22532601; PubMed Central PMCID: PMC3392364.

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Bidwell GL 3rd, Perkins E, Raucher D. A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth. Cancer Lett. 2012 Jun 28;319(2):136-143. doi: 10.1016/j.canlet.2011.12.042. Epub 2012 Jan 17. PubMed PMID: 22261328; PubMed Central PMCID: PMC3536021.

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Moktan S, Ryppa C, Kratz F, Raucher D. A thermally responsive biopolymer conjugated to an acid-sensitive derivative of paclitaxel stabilizes microtubules, arrests cell cycle, and induces apoptosis. Invest New Drugs. 2012 Feb;30(1):236-48. doi: 10.1007/s10637-010-9560-x. Epub 2010 Oct 12. PubMed PMID: 20938714.

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Hearst SM, Walker LR, Shao Q, Lopez M, Raucher D, Vig PJ. The design and delivery of a thermally responsive peptide to inhibit S100B-mediated neurodegeneration. Neuroscience. 2011 Dec 1;197:369-80. doi: 10.1016/j.neuroscience.2011.09.025. Epub 2011 Sep 17. PubMed PMID: 21958864; PubMed Central PMCID: PMC3210406.

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Bidwell GL 3rd, Raucher D. Cell penetrating elastin-like polypeptides for therapeutic peptide delivery. Adv Drug Deliv Rev. 2010 Dec 30;62(15):1486-96. doi: 10.1016/j.addr.2010.05.003. Epub 2010 May 15. Review. PubMed PMID: 20478348; PubMed Central PMCID: PMC2964383.

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Bidwell GL 3rd, Whittom AA, Thomas E, Lyons D, Hebert MD, Raucher D. A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation. Peptides. 2010 May;31(5):834-41. doi: 10.1016/j.peptides.2010.02.007. Epub 2010 Feb 16. PubMed PMID: 20167239; PubMed Central PMCID: PMC2872552.

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Massodi I, Moktan S, Rawat A, Bidwell GL 3rd, Raucher D. Inhibition of ovarian cancer cell proliferation by a cell cycle inhibitory peptide fused to a thermally responsive polypeptide carrier. Int J Cancer. 2010 Jan 15;126(2):533-44. doi: 10.1002/ijc.24725. PubMed PMID: 19588502; PubMed Central PMCID: PMC2795124.

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Raucher D, Moktan S, Massodi I, Bidwell GL 3rd. Therapeutic peptides for cancer therapy. Part II - cell cycle inhibitory peptides and apoptosis-inducing peptides. Expert Opin Drug Deliv. 2009 Oct;6(10):1049-64. doi: 10.1517/17425240903158909. Review. PubMed PMID: 19743895.

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Bidwell GL 3rd, Raucher D. Therapeutic peptides for cancer therapy. Part I - peptide inhibitors of signal transduction cascades. Expert Opin Drug Deliv. 2009 Oct;6(10):1033-47. doi: 10.1517/17425240903143745. Review. PubMed PMID: 19637980.

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Massodi I, Thomas E, Raucher D. Application of thermally responsive elastin-like polypeptide fused to a lactoferrin-derived peptide for treatment of pancreatic cancer. Molecules. 2009 Jun 4;14(6):1999-2015. doi: 10.3390/molecules14061999. PubMed PMID: 19513001; PubMed Central PMCID: PMC6254221.

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Bidwell GL 3rd, Davis AN, Raucher D. Targeting a c-Myc inhibitory polypeptide to specific intracellular compartments using cell penetrating peptides. J Control Release. 2009 Apr 2;135(1):2-10. doi: 10.1016/j.jconrel.2008.11.015. Epub 2008 Nov 28. PubMed PMID: 19095020.

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Massodi I, Bidwell GL 3rd, Davis A, Tausend A, Credit K, Flessner M, Raucher D. Inhibition of ovarian cancer cell metastasis by a fusion polypeptide Tat-ELP. Clin Exp Metastasis. 2009;26(3):251-60. doi: 10.1007/s10585-009-9237-z. Epub 2009 Jan 25. PubMed PMID: 19169893.

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Raucher D, Massodi I, Bidwell GL. Thermally targeted delivery of chemotherapeutics and anti-cancer peptides by elastin-like polypeptide. Expert Opin Drug Deliv. 2008 Mar;5(3):353-69. doi: 10.1517/17425247.5.3.353. Review. PubMed PMID: 18318656.

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Raucher D. Chapter 17: Application of laser tweezers to studies of membrane-cytoskeleton adhesion. Methods Cell Biol. 2008;89:451-66. doi: 10.1016/S0091-679X(08)00617-1. PubMed PMID: 19118686.

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Massodi I, Raucher D. A thermally responsive Tat-elastin-like polypeptide fusion protein induces membrane leakage, apoptosis, and cell death in human breast cancer cells. J Drug Target. 2007 Nov;15(9):611-22. doi: 10.1080/10611860701502780. PubMed PMID: 17968715.

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Bidwell GL 3rd, Davis AN, Fokt I, Priebe W, Raucher D. A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance. Invest New Drugs. 2007 Aug;25(4):313-26. doi: 10.1007/s10637-007-9053-8. Epub 2007 May 5. PubMed PMID: 17483874.

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Bidwell GL 3rd, Fokt I, Priebe W, Raucher D. Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin. Biochem Pharmacol. 2007 Mar 1;73(5):620-31. doi: 10.1016/j.bcp.2006.10.028. Epub 2006 Nov 10. PubMed PMID: 17161827.

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Bidwell GL 3rd, Raucher D. Enhancing the antiproliferative effect of topoisomerase II inhibitors using a polypeptide inhibitor of c-Myc. Biochem Pharmacol. 2006 Jan 12;71(3):248-56. doi: 10.1016/j.bcp.2005.10.041. PubMed PMID: 16316634.

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Massodi I, Bidwell GL 3rd, Raucher D. Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery. J Control Release. 2005 Nov 28;108(2-3):396-408. doi: 10.1016/j.jconrel.2005.08.007. Epub 2005 Sep 12. PubMed PMID: 16157413.

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Bidwell GL 3rd, Raucher D. Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy. Mol Cancer Ther. 2005 Jul;4(7):1076-85. doi: 10.1158/1535-7163.MCT-04-0253. PubMed PMID: 16020665.

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Dreher MR, Raucher D, Balu N, Michael Colvin O, Ludeman SM, Chilkoti A. Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy. J Control Release. 2003 Aug 28;91(1-2):31-43. doi: 10.1016/s0168-3659(03)00216-5. PubMed PMID: 12932635.

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Chilkoti A, Dreher MR, Meyer DE, Raucher D. Targeted drug delivery by thermally responsive polymers. Adv Drug Deliv Rev. 2002 Sep 13;54(5):613-30. doi: 10.1016/s0169-409x(02)00041-8. Review. PubMed PMID: 12204595.

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Raucher D, Sheetz MP. Phospholipase C activation by anesthetics decreases membrane-cytoskeleton adhesion. J Cell Sci. 2001 Oct;114(Pt 20):3759-66. doi: 10.1242/jcs.114.20.3759. PubMed PMID: 11707527.

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Raucher D, Chilkoti A. Enhanced uptake of a thermally responsive polypeptide by tumor cells in response to its hyperthermia-mediated phase transition. Cancer Res. 2001 Oct 1;61(19):7163-70. PubMed PMID: 11585750.

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Raucher D, Stauffer T, Chen W, Shen K, Guo S, York JD, Sheetz MP, Meyer T. Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell. 2000 Jan 21;100(2):221-8. doi: 10.1016/s0092-8674(00)81560-3. PubMed PMID: 10660045.

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Raucher D, Sheetz MP. Cell spreading and lamellipodial extension rate is regulated by membrane tension. J Cell Biol. 2000 Jan 10;148(1):127-36. doi: 10.1083/jcb.148.1.127. PubMed PMID: 10629223; PubMed Central PMCID: PMC2156205.

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