My Bibliography

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Kaur S, Rose RA. New insights into the effects of glucagon-like peptide-1 on heart rate and sinoatrial node function. Cardiovasc Res. 2024 Oct 14;120(12):1367-1368. doi: 10.1093/cvr/cvae150. PubMed PMID: 39028688.

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Moghtadaei M, Tagirova S, Ahmet I, Moen J, Lakatta EG, Rose RA. Lifelong longitudinal assessment of the contribution of multi-fractal fluctuations to heart rate and heart rate variability in aging mice: role of the sinoatrial node and autonomic nervous system. Geroscience. 2024 Oct;46(5):5085-5101. doi: 10.1007/s11357-024-01267-0. Epub 2024 Jul 5. PubMed PMID: 38967697; PubMed Central PMCID: PMC11336143.

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Rose RA, Howlett SE. Preclinical Studies on the Effects of Frailty in the Aging Heart. Can J Cardiol. 2024 Aug;40(8):1379-1393. doi: 10.1016/j.cjca.2024.03.003. Epub 2024 Mar 7. Review. PubMed PMID: 38460611.

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Gharagozloo K, Mehdizadeh M, Heckman G, Rose RA, Howlett J, Howlett SE, Nattel S. Heart Failure With Preserved Ejection Fraction in the Elderly Population: Basic Mechanisms and Clinical Considerations. Can J Cardiol. 2024 Aug;40(8):1424-1444. doi: 10.1016/j.cjca.2024.04.006. Epub 2024 Apr 10. Review. PubMed PMID: 38604339.

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Jansen HJ, McRae MD, Belke DD, Rose RA. Chronic angiotensin-converting enzyme inhibition attenuates frailty and protects against atrial fibrillation in aging mice. Heart Rhythm. 2024 Jul 15;. doi: 10.1016/j.hrthm.2024.07.016. [Epub ahead of print] PubMed PMID: 39019387.

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Dorey TW, McRae MD, Belke DD, Rose RA. PDE4D mediates impaired β-adrenergic receptor signalling in the sinoatrial node in mice with hypertensive heart disease. Cardiovasc Res. 2023 Dec 30;119(17):2697-2711. doi: 10.1093/cvr/cvad138. PubMed PMID: 37643895; PubMed Central PMCID: PMC10757582.

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Dorey TW, Liu Y, Jansen HJ, Bohne LJ, Mackasey M, Atkinson L, Prasai S, Belke DD, Fatehi-Hassanabad A, Fedak PWM, Rose RA. Natriuretic Peptide Receptor B Protects Against Atrial Fibrillation by Controlling Atrial cAMP Via Phosphodiesterase 2. Circ Arrhythm Electrophysiol. 2023 Nov;16(11):e012199. doi: 10.1161/CIRCEP.123.012199. Epub 2023 Nov 7. PubMed PMID: 37933567.

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Chakraborty P, Azam MA, Massé S, Lai PFH, Rose RA, Ibarra Moreno CA, Riazi S, Nanthakumar K. Uncoupling cytosolic calcium from membrane voltage by transient receptor potential melastatin 4 channel (TRPM4) modulation: A novel strategy to treat ventricular arrhythmias. Heart Rhythm O2. 2023 Nov;4(11):725-732. doi: 10.1016/j.hroo.2023.10.001. eCollection 2023 Nov. Review. PubMed PMID: 38034891; PubMed Central PMCID: PMC10685170.

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Banga S, Mishra M, Heinze-Milne SD, Jansen HJ, Rose RA, Howlett SE. Chronic testosterone deficiency increases late inward sodium current and promotes triggered activity in ventricular myocytes from aging male mice. Am J Physiol Heart Circ Physiol. 2023 Aug 1;325(2):H264-H277. doi: 10.1152/ajpheart.00505.2022. Epub 2023 Jun 30. PubMed PMID: 37389950.

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Bohne LJ, Jansen HJ, Dorey TW, Daniel IM, Jamieson KL, Belke DD, McRae MD, Rose RA. Glucagon-Like Peptide-1 Protects Against Atrial Fibrillation and Atrial Remodeling in Type 2 Diabetic Mice. JACC Basic Transl Sci. 2023 Aug;8(8):922-936. doi: 10.1016/j.jacbts.2023.01.005. eCollection 2023 Aug. PubMed PMID: 37719430; PubMed Central PMCID: PMC10504404.

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Ripplinger CM, Glukhov AV, Kay MW, Boukens BJ, Chiamvimonvat N, Delisle BP, Fabritz L, Hund TJ, Knollmann BC, Li N, Murray KT, Poelzing S, Quinn TA, Remme CA, Rentschler SL, Rose RA, Posnack NG. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals. Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1137-H1166. doi: 10.1152/ajpheart.00439.2022. Epub 2022 Oct 21. Review. PubMed PMID: 36269644; PubMed Central PMCID: PMC9678409.

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Jansen HJ, McRae MD, Mackasey M, Rose RA. Regional and temporal progression of atrial remodeling in angiotensin II mediated atrial fibrillation. Front Physiol. 2022;13:1021807. doi: 10.3389/fphys.2022.1021807. eCollection 2022. PubMed PMID: 36388100; PubMed Central PMCID: PMC9663483.

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Rose RA. Targeting the mitochondrial calcium uniporter to prevent ventricular arrhythmias in heart failure. Heart Rhythm. 2022 Oct;19(10):1736-1737. doi: 10.1016/j.hrthm.2022.06.021. Epub 2022 Jun 16. PubMed PMID: 35718317.

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Moghtadaei M, Dorey TW, Rose RA. Evaluation of non-linear heart rate variability using multi-scale multi-fractal detrended fluctuation analysis in mice: Roles of the autonomic nervous system and sinoatrial node. Front Physiol. 2022;13:970393. doi: 10.3389/fphys.2022.970393. eCollection 2022. PubMed PMID: 36237525; PubMed Central PMCID: PMC9552224.

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Dorey TW, Mackasey M, Jansen HJ, McRae MD, Bohne LJ, Liu Y, Belke DD, Atkinson L, Rose RA. Natriuretic peptide receptor B maintains heart rate and sinoatrial node function via cyclic GMP-mediated signalling. Cardiovasc Res. 2022 Jun 29;118(8):1917-1931. doi: 10.1093/cvr/cvab245. PubMed PMID: 34273155; PubMed Central PMCID: PMC9239581.

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Jansen HJ, Moghtadaei M, Rafferty SA, Belke DD, Rose RA. Loss of Natriuretic Peptide Receptor C Enhances Sinoatrial Node Dysfunction in Aging and Frail Mice. J Gerontol A Biol Sci Med Sci. 2022 May 5;77(5):902-908. doi: 10.1093/gerona/glab357. PubMed PMID: 34865023; PubMed Central PMCID: PMC9071455.

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Jamieson KL, Rose RA. New insights into ventricular arrhythmogenesis in a pure model of pulmonary arterial hypertension. Heart Rhythm. 2022 Jan;19(1):125-126. doi: 10.1016/j.hrthm.2021.10.002. Epub 2021 Oct 8. PubMed PMID: 34628041.

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Tuomi JM, Bohne LJ, Dorey TW, Jansen HJ, Liu Y, Jones DL, Rose RA. Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis. J Am Heart Assoc. 2021 Nov 16;10(22):e022369. doi: 10.1161/JAHA.121.022369. Epub 2021 Nov 2. PubMed PMID: 34726066; PubMed Central PMCID: PMC8751944.

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Dorey TW, Jansen HJ, Moghtadaei M, Jamieson KL, Rose RA. Impacts of frailty on heart rate variability in aging mice: Roles of the autonomic nervous system and sinoatrial node. Heart Rhythm. 2021 Nov;18(11):1999-2008. doi: 10.1016/j.hrthm.2021.07.069. Epub 2021 Aug 8. PubMed PMID: 34371195.

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Jøns C, Porta-Sánchez A, Lai PFH, Wauchop M, Massé S, Azam MA, Asta J, Rose RA, Nanthakumar K. Mechanism of and strategy to mitigate liraglutide-mediated positive chronotropy. Life Sci. 2021 Oct 1;282:119815. doi: 10.1016/j.lfs.2021.119815. Epub 2021 Jul 10. PubMed PMID: 34256040.

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Jansen HJ, Moghtadaei M, Rafferty SA, Rose RA. Atrial Fibrillation in Aging and Frail Mice: Modulation by Natriuretic Peptide Receptor C. Circ Arrhythm Electrophysiol. 2021 Sep;14(9):e010077. doi: 10.1161/CIRCEP.121.010077. Epub 2021 Sep 7. PubMed PMID: 34490788.

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Aguilar M, Rose RA, Takawale A, Nattel S, Reilly S. New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation. Cardiovasc Res. 2021 Jun 16;117(7):1645-1661. doi: 10.1093/cvr/cvab080. Review. PubMed PMID: 33723575; PubMed Central PMCID: PMC8208746.

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Liu Y, Jansen HJ, Krishnaswamy PS, Bogachev O, Rose RA. Impaired regulation of heart rate and sinoatrial node function by the parasympathetic nervous system in type 2 diabetic mice. Sci Rep. 2021 Jun 14;11(1):12465. doi: 10.1038/s41598-021-91937-2. PubMed PMID: 34127743; PubMed Central PMCID: PMC8203800.

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Sun B, Yao J, Ni M, Wei J, Zhong X, Guo W, Zhang L, Wang R, Belke D, Chen YX, Lieve KVV, Broendberg AK, Roston TM, Blankoff I, Kammeraad JA, von Alvensleben JC, Lazarte J, Vallmitjana A, Bohne LJ, Rose RA, Benitez R, Hove-Madsen L, Napolitano C, Hegele RA, Fill M, Sanatani S, Wilde AAM, Roberts JD, Priori SG, Jensen HK, Chen SRW. Cardiac ryanodine receptor calcium release deficiency syndrome. Sci Transl Med. 2021 Feb 3;13(579). doi: 10.1126/scitranslmed.aba7287. PubMed PMID: 33536282.

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Chakraborty P, Rose RA, Nair K, Downar E, Nanthakumar K. The rationale for repurposing funny current inhibition for management of ventricular arrhythmia. Heart Rhythm. 2021 Jan;18(1):130-137. doi: 10.1016/j.hrthm.2020.07.031. Epub 2020 Jul 29. Review. PubMed PMID: 32738405.

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Bohne LJ, Jansen HJ, Daniel I, Dorey TW, Moghtadaei M, Belke DD, Ezeani M, Rose RA. Electrical and structural remodeling contribute to atrial fibrillation in type 2 diabetic db/db mice. Heart Rhythm. 2021 Jan;18(1):118-129. doi: 10.1016/j.hrthm.2020.08.019. Epub 2020 Sep 7. PubMed PMID: 32911049.

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Dorey TW, Moghtadaei M, Rose RA. Altered heart rate variability in angiotensin II-mediated hypertension is associated with impaired autonomic nervous system signaling and intrinsic sinoatrial node dysfunction. Heart Rhythm. 2020 Aug;17(8):1360-1370. doi: 10.1016/j.hrthm.2020.03.014. Epub 2020 Mar 27. PubMed PMID: 32224266.

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Jansen HJ, Bohne LJ, Gillis AM, Rose RA. Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease. Heart Rhythm O2. 2020 Jun;1(2):147-159. doi: 10.1016/j.hroo.2020.05.002. eCollection 2020 Jun. PubMed PMID: 34113869; PubMed Central PMCID: PMC8183954.

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Polina I, Jansen HJ, Li T, Moghtadaei M, Bohne LJ, Liu Y, Krishnaswamy P, Egom EE, Belke DD, Rafferty SA, Ezeani M, Gillis AM, Rose RA. Loss of insulin signaling may contribute to atrial fibrillation and atrial electrical remodeling in type 1 diabetes. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7990-8000. doi: 10.1073/pnas.1914853117. Epub 2020 Mar 20. PubMed PMID: 32198206; PubMed Central PMCID: PMC7148583.

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MacDonald EA, Rose RA, Quinn TA. Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans. Front Physiol. 2020;11:170. doi: 10.3389/fphys.2020.00170. eCollection 2020. Review. PubMed PMID: 32194439; PubMed Central PMCID: PMC7063087.

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Jansen HJ, Rose RA. Isolation of Atrial Myocytes from Adult Mice. J Vis Exp. 2019 Jul 25;(149). doi: 10.3791/59588. PubMed PMID: 31403612.

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Ayaz O, Banga S, Heinze-Milne S, Rose RA, Pyle WG, Howlett SE. Long-term testosterone deficiency modifies myofilament and calcium-handling proteins and promotes diastolic dysfunction in the aging mouse heart. Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H768-H780. doi: 10.1152/ajpheart.00471.2018. Epub 2019 Jan 18. PubMed PMID: 30657724.

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Bohne LJ, Johnson D, Rose RA, Wilton SB, Gillis AM. The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic Insights. Front Physiol. 2019;10:135. doi: 10.3389/fphys.2019.00135. eCollection 2019. Review. PubMed PMID: 30863315; PubMed Central PMCID: PMC6399657.

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Jansen HJ, Mackasey M, Moghtadaei M, Liu Y, Kaur J, Egom EE, Tuomi JM, Rafferty SA, Kirkby AW, Rose RA. NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II-Mediated Atrial Fibrillation and Atrial Remodeling in Mice. Circ Arrhythm Electrophysiol. 2019 Jan;12(1):e006863. doi: 10.1161/CIRCEP.118.006863. PubMed PMID: 30636477.

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Mackasey M, Egom EE, Jansen HJ, Hua R, Moghtadaei M, Liu Y, Kaur J, McRae MD, Bogachev O, Rafferty SA, Ray G, Kirkby AW, Rose RA. Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice. JACC Basic Transl Sci. 2018 Dec;3(6):824-843. doi: 10.1016/j.jacbts.2018.08.004. eCollection 2018 Dec. PubMed PMID: 30623142; PubMed Central PMCID: PMC6314975.

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Jansen HJ, Mackasey M, Moghtadaei M, Belke DD, Egom EE, Tuomi JM, Rafferty SA, Kirkby AW, Rose RA. Distinct patterns of atrial electrical and structural remodeling in angiotensin II mediated atrial fibrillation. J Mol Cell Cardiol. 2018 Nov;124:12-25. doi: 10.1016/j.yjmcc.2018.09.011. Epub 2018 Sep 28. PubMed PMID: 30273558.

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Govindapillai A, Hotchkiss A, Baguma-Nibasheka M, Rose RA, Miquerol L, Smithies O, Maeda N, Pasumarthi KBS. Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system. Sci Rep. 2018 May 2;8(1):6939. doi: 10.1038/s41598-018-25292-0. PubMed PMID: 29720615; PubMed Central PMCID: PMC5932026.

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Moghtadaei M, Langille E, Rafferty SA, Bogachev O, Rose RA. Altered heart rate regulation by the autonomic nervous system in mice lacking natriuretic peptide receptor C (NPR-C). Sci Rep. 2017 Dec 14;7(1):17564. doi: 10.1038/s41598-017-17690-7. PubMed PMID: 29242602; PubMed Central PMCID: PMC5730580.

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Egom EE, Feridooni T, Pharithi RB, Khan B, Shiwani HA, Maher V, El Hiani Y, Rose RA, Pasumarthi KB, Ribama HA. Erratum: New insights and new hope for pulmonary arterial hypertension: natriuretic peptides clearance receptor as a novel therapeutic target for a complex disease. Int J Physiol Pathophysiol Pharmacol. 2017;9(5):164. eCollection 2017. PubMed PMID: 29218116; PubMed Central PMCID: PMC5698694.

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MacDonald EA, Stoyek MR, Rose RA, Quinn TA. Intrinsic regulation of sinoatrial node function and the zebrafish as a model of stretch effects on pacemaking. Prog Biophys Mol Biol. 2017 Nov;130(Pt B):198-211. doi: 10.1016/j.pbiomolbio.2017.07.012. Epub 2017 Jul 22. PubMed PMID: 28743586.

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Parks RJ, Bogachev O, Mackasey M, Ray G, Rose RA, Howlett SE. The impact of ovariectomy on cardiac excitation-contraction coupling is mediated through cAMP/PKA-dependent mechanisms. J Mol Cell Cardiol. 2017 Oct;111:51-60. doi: 10.1016/j.yjmcc.2017.07.118. Epub 2017 Aug 1. PubMed PMID: 28778766.

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Egom EE, Feridooni T, Pharithi RB, Khan B, Shiwani HA, Maher V, El Hiani Y, Rose RA, Pasumarthi KB, Ribama HA. New insights and new hope for pulmonary arterial hypertension: natriuretic peptides clearance receptor as a novel therapeutic target for a complex disease. Int J Physiol Pathophysiol Pharmacol. 2017;9(4):112-118. eCollection 2017. PubMed PMID: 28951773; PubMed Central PMCID: PMC5592245.

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Feridooni HA, Kane AE, Ayaz O, Boroumandi A, Polidovitch N, Tsushima RG, Rose RA, Howlett SE. The impact of age and frailty on ventricular structure and function in C57BL/6J mice. J Physiol. 2017 Jun 15;595(12):3721-3742. doi: 10.1113/JP274134. Epub 2017 May 14. PubMed PMID: 28502095; PubMed Central PMCID: PMC5471507.

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Jansen HJ, Moghtadaei M, Mackasey M, Rafferty SA, Bogachev O, Sapp JL, Howlett SE, Rose RA. Atrial structure, function and arrhythmogenesis in aged and frail mice. Sci Rep. 2017 Mar 14;7:44336. doi: 10.1038/srep44336. PubMed PMID: 28290548; PubMed Central PMCID: PMC5349540.

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Rockwood K, Blodgett JM, Theou O, Sun MH, Feridooni HA, Mitnitski A, Rose RA, Godin J, Gregson E, Howlett SE. A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice. Sci Rep. 2017 Feb 21;7:43068. doi: 10.1038/srep43068. PubMed PMID: 28220898; PubMed Central PMCID: PMC5318852.

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Moghtadaei M, Jansen HJ, Mackasey M, Rafferty SA, Bogachev O, Sapp JL, Howlett SE, Rose RA. The impacts of age and frailty on heart rate and sinoatrial node function. J Physiol. 2016 Dec 1;594(23):7105-7126. doi: 10.1113/JP272979. Epub 2016 Oct 17. PubMed PMID: 27598221; PubMed Central PMCID: PMC5134407.

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Moghtadaei M, Polina I, Rose RA. Electrophysiological effects of natriuretic peptides in the heart are mediated by multiple receptor subtypes. Prog Biophys Mol Biol. 2016 Jan;120(1-3):37-49. doi: 10.1016/j.pbiomolbio.2015.12.001. Epub 2015 Dec 15. Review. PubMed PMID: 26701223.

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Hua R, MacLeod SL, Polina I, Moghtadaei M, Jansen HJ, Bogachev O, O'Blenes SB, Sapp JL, Legare JF, Rose RA. Effects of Wild-Type and Mutant Forms of Atrial Natriuretic Peptide on Atrial Electrophysiology and Arrhythmogenesis. Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1240-54. doi: 10.1161/CIRCEP.115.002896. Epub 2015 Jul 30. PubMed PMID: 26227000.

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Krishnaswamy PS, Egom EE, Moghtadaei M, Jansen HJ, Azer J, Bogachev O, Mackasey M, Robbins C, Rose RA. Altered parasympathetic nervous system regulation of the sinoatrial node in Akita diabetic mice. J Mol Cell Cardiol. 2015 May;82:125-35. doi: 10.1016/j.yjmcc.2015.02.024. Epub 2015 Mar 6. PubMed PMID: 25754673.

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Egom EE, Vella K, Hua R, Jansen HJ, Moghtadaei M, Polina I, Bogachev O, Hurnik R, Mackasey M, Rafferty S, Ray G, Rose RA. Impaired sinoatrial node function and increased susceptibility to atrial fibrillation in mice lacking natriuretic peptide receptor C. J Physiol. 2015 Mar 1;593(5):1127-46. doi: 10.1113/jphysiol.2014.283135. Epub 2015 Jan 12. PubMed PMID: 25641115; PubMed Central PMCID: PMC4358675.