My Bibliography

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Tanaka Y, Hino H, Takeya K, Eto M. Abemaciclib and Vacuolin-1 induce vacuole-like autolysosome formation - A new tool to study autophagosome-lysosome fusion. Biochem Biophys Res Commun. 2022 Jul 23;614:191-197. doi: 10.1016/j.bbrc.2022.05.027. Epub 2022 May 14. PubMed PMID: 35598430.

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Tanaka Y, Kusumoto SY, Honma Y, Takeya K, Eto M. Overexpression of progranulin increases pathological protein accumulation by suppressing autophagic flux. Biochem Biophys Res Commun. 2022 Jun 30;611:78-84. doi: 10.1016/j.bbrc.2022.04.064. Epub 2022 Apr 16. PubMed PMID: 35483222.

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Pasapera AM, Heissler SM, Eto M, Nishimura Y, Fischer RS, Thiam HR, Waterman CM. MARK2 regulates directed cell migration through modulation of myosin II contractility and focal adhesion organization. Curr Biol. 2022 Jun 20;32(12):2704-2718.e6. doi: 10.1016/j.cub.2022.04.088. Epub 2022 May 19. PubMed PMID: 35594862; PubMed Central PMCID: PMC9354676.

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Eto M, Katsuki S, Ohashi M, Miyagawa Y, Tanaka Y, Takeya K, Kitazawa T. Possible roles of N- and C-terminal unstructured tails of CPI-17 in regulating Ca(2+) sensitization force of smooth muscle. J Smooth Muscle Res. 2022;58(0):22-33. doi: 10.1540/jsmr.58.22. PubMed PMID: 35418530; PubMed Central PMCID: PMC9006046.

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Kitazawa T, Matsui T, Katsuki S, Goto A, Akagi K, Hatano N, Tokumitsu H, Takeya K, Eto M. A temporal Ca(2+) desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKβ/PP2A pathways. Am J Physiol Cell Physiol. 2021 Sep 1;321(3):C549-C558. doi: 10.1152/ajpcell.00136.2021. Epub 2021 Jun 9. PubMed PMID: 34106787.

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Eto M, Katsuki S, Tanaka Y, Takeya K. Kinase activity-tagged western blotting assay. Biotechniques. 2020 Apr;68(4):211-213. doi: 10.2144/btn-2019-0136. Epub 2020 Jan 15. PubMed PMID: 31939317.

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Artamonov MV, Sonkusare SK, Good ME, Momotani K, Eto M, Isakson BE, Le TH, Cope EL, Derewenda ZS, Derewenda U, Somlyo AV. RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na(+)/H(+) exchanger. Sci Signal. 2018 Oct 30;11(554). doi: 10.1126/scisignal.aar3924. PubMed PMID: 30377223; PubMed Central PMCID: PMC6474246.

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Takai A, Eto M, Hirano K, Takeya K, Wakimoto T, Watanabe M. Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology. J Physiol Sci. 2018 Jan;68(1):1-17. doi: 10.1007/s12576-017-0556-6. Epub 2017 Jul 5. Review. PubMed PMID: 28681362; PubMed Central PMCID: PMC5754374.

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Filter JJ, Williams BC, Eto M, Shalloway D, Goldberg ML. Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1). Elife. 2017 Apr 7;6. doi: 10.7554/eLife.24665. PubMed PMID: 28387646; PubMed Central PMCID: PMC5441869.

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Eto M, Kitazawa T. Diversity and plasticity in signaling pathways that regulate smooth muscle responsiveness: Paradigms and paradoxes for the myosin phosphatase, the master regulator of smooth muscle contraction. J Smooth Muscle Res. 2017;53(0):1-19. doi: 10.1540/jsmr.53.1. Review. PubMed PMID: 28260704; PubMed Central PMCID: PMC5364378.

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Siegman MJ, Eto M, Butler TM. Remodeling of the rat distal colon in diabetes: function and ultrastructure. Am J Physiol Cell Physiol. 2016 Jan 15;310(2):C151-60. doi: 10.1152/ajpcell.00253.2015. Epub 2015 Nov 11. PubMed PMID: 26561639; PubMed Central PMCID: PMC4719031.

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Zhao Y, Shapiro SS, Eto M. F-actin clustering and cell dysmotility induced by the pathological W148R missense mutation of filamin B at the actin-binding domain. Am J Physiol Cell Physiol. 2016 Jan 1;310(1):C89-98. doi: 10.1152/ajpcell.00274.2015. Epub 2015 Oct 21. PubMed PMID: 26491051; PubMed Central PMCID: PMC4698447.

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Khasnis M, Nakatomi A, Gumpper K, Eto M. Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1. Biochemistry. 2014 Apr 29;53(16):2701-9. doi: 10.1021/bi5001728. Epub 2014 Apr 18. PubMed PMID: 24712327; PubMed Central PMCID: PMC4010256.

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Eto M, Kirkbride JA, Chugh R, Karikari NK, Kim JI. Nuclear localization of CPI-17, a protein phosphatase-1 inhibitor protein, affects histone H3 phosphorylation and corresponds to proliferation of cancer and smooth muscle cells. Biochem Biophys Res Commun. 2013 Apr 26;434(1):137-42. doi: 10.1016/j.bbrc.2013.03.055. Epub 2013 Mar 26. PubMed PMID: 23541585; PubMed Central PMCID: PMC3644852.

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Eto M, Brautigan DL. Endogenous inhibitor proteins that connect Ser/Thr kinases and phosphatases in cell signaling. IUBMB Life. 2012 Sep;64(9):732-9. doi: 10.1002/iub.1067. Epub 2012 Jul 20. Review. PubMed PMID: 22815089; PubMed Central PMCID: PMC3422418.

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Tazzeo T, Bates G, Roman HN, Lauzon AM, Khasnis MD, Eto M, Janssen LJ. Caffeine relaxes smooth muscle through actin depolymerization. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L334-42. doi: 10.1152/ajplung.00103.2012. Epub 2012 Jun 8. PubMed PMID: 22683573; PubMed Central PMCID: PMC3774218.

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Kim JI, Urban M, Young GD, Eto M. Reciprocal regulation controlling the expression of CPI-17, a specific inhibitor protein for the myosin light chain phosphatase in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2012 Jul 1;303(1):C58-68. doi: 10.1152/ajpcell.00118.2012. Epub 2012 Apr 25. PubMed PMID: 22538237; PubMed Central PMCID: PMC3404528.

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Khromov AS, Momotani K, Jin L, Artamonov MV, Shannon J, Eto M, Somlyo AV. Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle. J Biol Chem. 2012 Jun 15;287(25):20975-85. doi: 10.1074/jbc.M112.341479. Epub 2012 Apr 27. PubMed PMID: 22544752; PubMed Central PMCID: PMC3375521.

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Terai M, Eto M, Young GD, Berd D, Mastrangelo MJ, Tamura Y, Harigaya K, Sato T. Interleukin 6 mediates production of interleukin 10 in metastatic melanoma. Cancer Immunol Immunother. 2012 Feb;61(2):145-155. doi: 10.1007/s00262-011-1084-5. Epub 2011 Aug 19. PubMed PMID: 21853302; PubMed Central PMCID: PMC11029758.

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Grindrod S, Suy S, Fallen S, Eto M, Toretsky J, Brown ML. Effects of a fluorescent Myosin light chain phosphatase inhibitor on prostate cancer cells. Front Oncol. 2011;1:27. doi: 10.3389/fonc.2011.00027. eCollection 2011. PubMed PMID: 22655237; PubMed Central PMCID: PMC3356144.

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Kim JI, Jung SW, Yang E, Park KM, Eto M, Kim IK. Heat shock augments angiotensin II-induced vascular contraction through increased production of reactive oxygen species. Biochem Biophys Res Commun. 2010 Aug 27;399(3):452-7. doi: 10.1016/j.bbrc.2010.07.115. Epub 2010 Aug 3. PubMed PMID: 20688045.

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Eto M. Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors. J Biol Chem. 2009 Dec 18;284(51):35273-7. doi: 10.1074/jbc.R109.059972. Review. PubMed PMID: 19846560; PubMed Central PMCID: PMC2790955.

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Mori S, Iwaoka R, Eto M, Ohki SY. Solution structure of the inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1. Proteins. 2009 Nov 15;77(3):732-5. doi: 10.1002/prot.22529. PubMed PMID: 19701943; PubMed Central PMCID: PMC2796628.

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Xiao L, Eto M, Kazanietz MG. ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK. J Biol Chem. 2009 Oct 23;284(43):29365-75. doi: 10.1074/jbc.M109.007971. Epub 2009 Aug 10. PubMed PMID: 19667069; PubMed Central PMCID: PMC2785568.

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Khromov A, Choudhury N, Stevenson AS, Somlyo AV, Eto M. Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction. J Biol Chem. 2009 Aug 7;284(32):21569-79. doi: 10.1074/jbc.M109.019729. Epub 2009 Jun 15. PubMed PMID: 19531490; PubMed Central PMCID: PMC2755881.

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Kim JI, Young GD, Jin L, Somlyo AV, Eto M. Expression of CPI-17 in smooth muscle during embryonic development and in neointimal lesion formation. Histochem Cell Biol. 2009 Aug;132(2):191-8. doi: 10.1007/s00418-009-0604-2. Epub 2009 May 13. PubMed PMID: 19437030; PubMed Central PMCID: PMC2878480.

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Kitazawa T, Semba S, Huh YH, Kitazawa K, Eto M. Nitric oxide-induced biphasic mechanism of vascular relaxation via dephosphorylation of CPI-17 and MYPT1. J Physiol. 2009 Jul 15;587(Pt 14):3587-603. doi: 10.1113/jphysiol.2009.172189. Epub 2009 May 26. PubMed PMID: 19470783; PubMed Central PMCID: PMC2742283.

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Freitas MR, Eto M, Kirkbride JA, Schott C, Sassard J, Stoclet JC. Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle. Fundam Clin Pharmacol. 2009 Apr;23(2):169-78. doi: 10.1111/j.1472-8206.2008.00658.x. Epub 2009 Mar 9. PubMed PMID: 19298234; PubMed Central PMCID: PMC2878275.

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Neppl RL, Lubomirov LT, Momotani K, Pfitzer G, Eto M, Somlyo AV. Thromboxane A2-induced bi-directional regulation of cerebral arterial tone. J Biol Chem. 2009 Mar 6;284(10):6348-60. doi: 10.1074/jbc.M807040200. Epub 2008 Dec 17. PubMed PMID: 19095646; PubMed Central PMCID: PMC2649081.

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Eto M, Kitazawa T, Matsuzawa F, Aikawa S, Kirkbride JA, Isozumi N, Nishimura Y, Brautigan DL, Ohki SY. Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor. Structure. 2007 Dec;15(12):1591-602. doi: 10.1016/j.str.2007.10.014. PubMed PMID: 18073109; PubMed Central PMCID: PMC2217667.

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Eto M, Kirkbride J, Elliott E, Lo SH, Brautigan DL. Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions. J Biol Chem. 2007 Jun 15;282(24):17806-15. doi: 10.1074/jbc.M700944200. Epub 2007 Apr 15. PubMed PMID: 17435217.

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Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T. Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle. Circ Res. 2007 Jan 5;100(1):121-9. doi: 10.1161/01.RES.0000253902.90489.df. Epub 2006 Dec 7. PubMed PMID: 17158339; PubMed Central PMCID: PMC2212616.

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Eto M, Brautigan DL. Assay for three-way interaction of protein phosphatase-1 (Glc7) with regulatory subunits plus phosphatase inhibitor-2. Methods Mol Biol. 2007;365:197-208. doi: 10.1385/1-59745-267-X:197. PubMed PMID: 17200563.

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Woodsome TP, Polzin A, Kitazawa K, Eto M, Kitazawa T. Agonist- and depolarization-induced signals for myosin light chain phosphorylation and force generation of cultured vascular smooth muscle cells. J Cell Sci. 2006 May 1;119(Pt 9):1769-80. doi: 10.1242/jcs.02805. Epub 2006 Apr 11. PubMed PMID: 16608882.

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Eto M, Kirkbride JA, Brautigan DL. Assembly of MYPT1 with protein phosphatase-1 in fibroblasts redirects localization and reorganizes the actin cytoskeleton. Cell Motil Cytoskeleton. 2005 Oct;62(2):100-9. doi: 10.1002/cm.20088. PubMed PMID: 16106448.

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Eto M, Yazawa M. [Function and regulation of Ser/Thr-specific protein phosphatase-1 (PP1)]. Seikagaku. 2005 Oct;77(10):1308-16. Review. PubMed PMID: 16296323.

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Pang H, Guo Z, Su W, Xie Z, Eto M, Gong MC. RhoA-Rho kinase pathway mediates thrombin- and U-46619-induced phosphorylation of a myosin phosphatase inhibitor, CPI-17, in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2005 Aug;289(2):C352-60. doi: 10.1152/ajpcell.00111.2005. Epub 2005 Apr 6. PubMed PMID: 15814590.

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Matsuzawa F, Aikawa SI, Ohki SY, Eto M. Phospho-pivot modeling predicts specific interactions of protein phosphatase-1 with a phospho-inhibitor protein CPI-17. J Biochem. 2005 May;137(5):633-41. doi: 10.1093/jb/mvi077. PubMed PMID: 15944417.

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Stevenson AS, Matthew JD, Eto M, Luo S, Somlyo AP, Somlyo AV. Uncoupling of GPCR and RhoA-induced Ca2+-sensitization of chicken amnion smooth muscle lacking CPI-17. FEBS Lett. 2004 Dec 3;578(1-2):73-9. doi: 10.1016/j.febslet.2004.10.072. PubMed PMID: 15581619.

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Eto M, Kitazawa T, Brautigan DL. Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8888-93. doi: 10.1073/pnas.0307812101. Epub 2004 Jun 7. PubMed PMID: 15184667; PubMed Central PMCID: PMC428442.

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Kitazawa T, Polzin AN, Eto M. CPI-17-deficient smooth muscle of chicken. J Physiol. 2004 Jun 1;557(Pt 2):515-28. doi: 10.1113/jphysiol.2004.064543. Epub 2004 Apr 16. PubMed PMID: 15090608; PubMed Central PMCID: PMC1665100.

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Murthy KS, Zhou H, Grider JR, Brautigan DL, Eto M, Makhlouf GM. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. Biochem J. 2003 Aug 15;374(Pt 1):145-55. doi: 10.1042/BJ20021274. PubMed PMID: 12733988; PubMed Central PMCID: PMC1223565.

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Erdodi F, Kiss E, Walsh MP, Stefansson B, Deng JT, Eto M, Brautigan DL, Hartshorne DJ. Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun. 2003 Jun 27;306(2):382-7. doi: 10.1016/s0006-291x(03)00976-8. PubMed PMID: 12804574.

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Ohki Sy, Eto M, Shimizu M, Takada R, Brautigan DL, Kainosho M. Distinctive solution conformation of phosphatase inhibitor CPI-17 substituted with aspartate at the phosphorylation-site threonine residue. J Mol Biol. 2003 Mar 7;326(5):1539-47. doi: 10.1016/s0022-2836(03)00048-2. PubMed PMID: 12595264.

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Kitazawa T, Eto M, Woodsome TP, Khalequzzaman M. Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle. J Physiol. 2003 Feb 1;546(Pt 3):879-89. doi: 10.1113/jphysiol.2002.029306. PubMed PMID: 12563012; PubMed Central PMCID: PMC2342583.

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Somlyo AV, Phelps C, Dipierro C, Eto M, Read P, Barrett M, Gibson JJ, Burnitz MC, Myers C, Somlyo AP. Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants. FASEB J. 2003 Feb;17(2):223-34. doi: 10.1096/fj.02-0655com. PubMed PMID: 12554701.

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Eto M, Leach C, Tountas NA, Brautigan DL. Phosphoprotein inhibitors of protein phosphatase-1. Methods Enzymol. 2003;366:243-60. doi: 10.1016/s0076-6879(03)66019-2. PubMed PMID: 14674253.

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Eto M, Bock R, Brautigan DL, Linden DJ. Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor. Neuron. 2002 Dec 19;36(6):1145-58. doi: 10.1016/s0896-6273(02)01107-8. PubMed PMID: 12495628.

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Eto M, Elliott E, Prickett TD, Brautigan DL. Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. J Biol Chem. 2002 Nov 15;277(46):44013-20. doi: 10.1074/jbc.M208035200. Epub 2002 Sep 6. PubMed PMID: 12221103.

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Deng JT, Sutherland C, Brautigan DL, Eto M, Walsh MP. Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. Biochem J. 2002 Oct 15;367(Pt 2):517-24. doi: 10.1042/BJ20020522. PubMed PMID: 12144526; PubMed Central PMCID: PMC1222907.