My Bibliography

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Papa A, Del Rivero Morfin PJ, Chen BX, Yang L, Katchman AN, Zakharov SI, Liu G, Bohnen MS, Zheng V, Katz M, Subramaniam S, Hirsch JA, Weiss S, Dascal N, Karlin A, Pitt GS, Colecraft HM, Ben-Johny M, Marx SO. A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels. J Clin Invest. 2024 Jan 16;134(5). doi: 10.1172/JCI176943. PubMed PMID: 38227371; PubMed Central PMCID: PMC10904049.

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Colombo S, Reddy HP, Petri S, Williams DJ, Shalomov B, Dhindsa RS, Gelfman S, Krizay D, Bera AK, Yang M, Peng Y, Makinson CD, Boland MJ, Frankel WN, Goldstein DB, Dascal N. Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor. Front Cell Neurosci. 2023;17:1175895. doi: 10.3389/fncel.2023.1175895. eCollection 2023. PubMed PMID: 37275776; PubMed Central PMCID: PMC10232839.

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Cui M, Xu K, Gada KD, Shalomov B, Ban M, Eptaminitaki GC, Kawano T, Plant LD, Dascal N, Logothetis DE. A novel small-molecule selective activator of homomeric GIRK4 channels. J Biol Chem. 2022 Jun;298(6):102009. doi: 10.1016/j.jbc.2022.102009. Epub 2022 May 4. PubMed PMID: 35525275; PubMed Central PMCID: PMC9194863.

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Friesacher T, Reddy HP, Bernsteiner H, Carlo Combista J, Shalomov B, Bera AK, Zangerl-Plessl EM, Dascal N, Stary-Weinzinger A. A selectivity filter mutation provides insights into gating regulation of a K(+) channel. Commun Biol. 2022 Apr 11;5(1):345. doi: 10.1038/s42003-022-03303-1. PubMed PMID: 35411015; PubMed Central PMCID: PMC9001731.

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Shalomov B, Handklo-Jamal R, Reddy HP, Theodor N, Bera AK, Dascal N. A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5). J Physiol. 2022 Mar;600(6):1419-1437. doi: 10.1113/JP282690. Epub 2022 Jan 17. PubMed PMID: 34957562.

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Reddy HP, Yakubovich D, Keren-Raifman T, Tabak G, Tsemakhovich VA, Pedersen MH, Shalomov B, Colombo S, Goldstein DB, Javitch JA, Bera AK, Dascal N. Encephalopathy-causing mutations in Gβ(1) (GNB1) alter regulation of neuronal GIRK channels. iScience. 2021 Sep 24;24(9):103018. doi: 10.1016/j.isci.2021.103018. eCollection 2021 Sep 24. PubMed PMID: 34522861; PubMed Central PMCID: PMC8426278.

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Katz M, Subramaniam S, Chomsky-Hecht O, Tsemakhovich V, Flockerzi V, Klussmann E, Hirsch JA, Weiss S, Dascal N. Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms. Proc Natl Acad Sci U S A. 2021 May 25;118(21). doi: 10.1073/pnas.2100021118. PubMed PMID: 34001616; PubMed Central PMCID: PMC8166151.

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Berlin S, Artzy E, Handklo-Jamal R, Kahanovitch U, Parnas H, Dascal N, Yakubovich D. A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors. Front Pharmacol. 2020;11:1216. doi: 10.3389/fphar.2020.01216. eCollection 2020. PubMed PMID: 32903404; PubMed Central PMCID: PMC7435011.

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Handklo-Jamal R, Meisel E, Yakubovich D, Vysochek L, Beinart R, Glikson M, McMullen JR, Dascal N, Nof E, Oz S. Andersen-Tawil Syndrome Is Associated With Impaired PIP(2) Regulation of the Potassium Channel Kir2.1. Front Pharmacol. 2020;11:672. doi: 10.3389/fphar.2020.00672. eCollection 2020. PubMed PMID: 32499698; PubMed Central PMCID: PMC7243181.

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Tabak G, Keren-Raifman T, Kahanovitch U, Dascal N. Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner. Sci Rep. 2019 Jan 24;9(1):508. doi: 10.1038/s41598-018-36833-y. PubMed PMID: 30679535; PubMed Central PMCID: PMC6346094.

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Raifman TK, Kumar P, Haase H, Klussmann E, Dascal N, Weiss S. Protein kinase C enhances plasma membrane expression of cardiac L-type calcium channel, Ca(V)1.2. Channels (Austin). 2017 Nov 2;11(6):604-615. doi: 10.1080/19336950.2017.1369636. Epub 2017 Sep 21. PubMed PMID: 28901828; PubMed Central PMCID: PMC5786194.

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Dascal N, Rubinstein M. Lithium reduces the span of G protein-activated K(+) (GIRK) channel inhibition in hippocampal neurons. Bipolar Disord. 2017 Nov;19(7):568-574. doi: 10.1111/bdi.12536. Epub 2017 Sep 12. PubMed PMID: 28895268.

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Kahanovitch U, Berlin S, Dascal N. Collision coupling in the GABA(B) receptor-G protein-GIRK signaling cascade. FEBS Lett. 2017 Sep;591(18):2816-2825. doi: 10.1002/1873-3468.12756. Epub 2017 Aug 21. PubMed PMID: 28724189.

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Oz S, Pankonien I, Belkacemi A, Flockerzi V, Klussmann E, Haase H, Dascal N. Protein kinase A regulates C-terminally truncated Ca(V) 1.2 in Xenopus oocytes: roles of N- and C-termini of the α(1C) subunit. J Physiol. 2017 May 15;595(10):3181-3202. doi: 10.1113/JP274015. Epub 2017 Mar 23. PubMed PMID: 28194788; PubMed Central PMCID: PMC5430219.

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Benmocha Guggenheimer A, Almagor L, Tsemakhovich V, Tripathy DR, Hirsch JA, Dascal N. Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca(2+) channel. Channels (Austin). 2016;10(1):55-68. doi: 10.1080/19336950.2015.1108499. PubMed PMID: 26577286; PubMed Central PMCID: PMC4802761.

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Yakubovich D, Berlin S, Kahanovitch U, Rubinstein M, Farhy-Tselnicker I, Styr B, Keren-Raifman T, Dessauer CW, Dascal N. A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ. PLoS Comput Biol. 2015 Nov;11(11):e1004598. doi: 10.1371/journal.pcbi.1004598. eCollection 2015 Nov. PubMed PMID: 26544551; PubMed Central PMCID: PMC4636287.

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Dascal N, Kahanovitch U. The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels. Int Rev Neurobiol. 2015;123:27-85. doi: 10.1016/bs.irn.2015.06.001. Epub 2015 Jul 26. Review. PubMed PMID: 26422982.

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Weiss S, Dascal N. Molecular Aspects of Modulation of L-type Calcium Channels by Protein Kinase C. Curr Mol Pharmacol. 2015;8(1):43-53. doi: 10.2174/1874467208666150507094733. Review. PubMed PMID: 25966700.

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Kahanovitch U, Tsemakhovich V, Berlin S, Rubinstein M, Styr B, Castel R, Peleg S, Tabak G, Dessauer CW, Ivanina T, Dascal N. Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1. J Physiol. 2014 Dec 15;592(24):5373-90. doi: 10.1113/jphysiol.2014.283218. Epub 2014 Nov 10. PubMed PMID: 25384780; PubMed Central PMCID: PMC4270501.

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Edelheit O, Ben-Shahar R, Dascal N, Hanukoglu A, Hanukoglu I. Conserved charged residues at the surface and interface of epithelial sodium channel subunits--roles in cell surface expression and the sodium self-inhibition response. FEBS J. 2014 Apr;281(8):2097-111. doi: 10.1111/febs.12765. Epub 2014 Mar 17. PubMed PMID: 24571549.

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Farhy Tselnicker I, Tsemakhovich V, Rishal I, Kahanovitch U, Dessauer CW, Dascal N. Dual regulation of G proteins and the G-protein-activated K+ channels by lithium. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5018-23. doi: 10.1073/pnas.1316425111. Epub 2014 Mar 17. PubMed PMID: 24639496; PubMed Central PMCID: PMC3977261.

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Weiss S, Oz S, Benmocha A, Dascal N. Regulation of cardiac L-type Ca²⁺ channel CaV1.2 via the β-adrenergic-cAMP-protein kinase A pathway: old dogmas, advances, and new uncertainties. Circ Res. 2013 Aug 16;113(5):617-31. doi: 10.1161/CIRCRESAHA.113.301781. PubMed PMID: 23948586.

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Oz S, Benmocha A, Sasson Y, Sachyani D, Almagor L, Lee A, Hirsch JA, Dascal N. Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1. J Biol Chem. 2013 May 3;288(18):12680-91. doi: 10.1074/jbc.M113.460949. Epub 2013 Mar 25. PubMed PMID: 23530039; PubMed Central PMCID: PMC3642314.

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Weisbrod D, Peretz A, Ziskind A, Menaker N, Oz S, Barad L, Eliyahu S, Itskovitz-Eldor J, Dascal N, Khananshvili D, Binah O, Attali B. SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):E1685-94. doi: 10.1073/pnas.1221022110. Epub 2013 Apr 15. PubMed PMID: 23589888; PubMed Central PMCID: PMC3645592.

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Treiber F, Rosker C, Keren-Raifman T, Steinecker B, Gorischek A, Dascal N, Schreibmayer W. Molecular basis of the facilitation of the heterooligomeric GIRK1/GIRK4 complex by cAMP dependent protein kinase. Biochim Biophys Acta. 2013 Apr;1828(4):1214-21. doi: 10.1016/j.bbamem.2012.12.016. Epub 2013 Jan 7. PubMed PMID: 23305758; PubMed Central PMCID: PMC3787752.

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Edvardson S, Oz S, Abulhijaa FA, Taher FB, Shaag A, Zenvirt S, Dascal N, Elpeleg O. Early infantile epileptic encephalopathy associated with a high voltage gated calcium channelopathy. J Med Genet. 2013 Feb;50(2):118-23. doi: 10.1136/jmedgenet-2012-101223. PubMed PMID: 23339110.

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Weiss S, Keren-Raifman T, Oz S, Ben Mocha A, Haase H, Dascal N. Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: antagonistic effects of Gβγ and protein kinase C. Channels (Austin). 2012 Nov-Dec;6(6):426-37. doi: 10.4161/chan.22016. Epub 2012 Sep 18. PubMed PMID: 22990911; PubMed Central PMCID: PMC3536727.

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Almagor L, Chomsky-Hecht O, Ben-Mocha A, Hendin-Barak D, Dascal N, Hirsch JA. Ca(V)1.2 I-II linker structure and Timothy syndrome. Channels (Austin). 2012 Nov-Dec;6(6):468-72. doi: 10.4161/chan.22078. Epub 2012 Sep 18. PubMed PMID: 22990809; PubMed Central PMCID: PMC3536733.

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Almagor L, Chomsky-Hecht O, Ben-Mocha A, Hendin-Barak D, Dascal N, Hirsch JA. The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis. J Neurosci. 2012 May 30;32(22):7602-13. doi: 10.1523/JNEUROSCI.5727-11.2012. PubMed PMID: 22649239; PubMed Central PMCID: PMC6703595.

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Pankonien I, Otto A, Dascal N, Morano I, Haase H. Ahnak1 interaction is affected by phosphorylation of Ser-296 on Cavβ₂. Biochem Biophys Res Commun. 2012 May 4;421(2):184-9. doi: 10.1016/j.bbrc.2012.03.132. Epub 2012 Apr 4. PubMed PMID: 22497893.

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Berlin S, Tsemakhovich VA, Castel R, Ivanina T, Dessauer CW, Keren-Raifman T, Dascal N. Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits. J Biol Chem. 2011 Sep 23;286(38):33223-35. doi: 10.1074/jbc.M111.271056. Epub 2011 Jul 27. PubMed PMID: 21795707; PubMed Central PMCID: PMC3190912.

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Oz S, Tsemakhovich V, Christel CJ, Lee A, Dascal N. CaBP1 regulates voltage-dependent inactivation and activation of Ca(V)1.2 (L-type) calcium channels. J Biol Chem. 2011 Apr 22;286(16):13945-53. doi: 10.1074/jbc.M110.198424. Epub 2011 Mar 7. PubMed PMID: 21383011; PubMed Central PMCID: PMC3077595.

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Edelheit O, Hanukoglu I, Dascal N, Hanukoglu A. Identification of the roles of conserved charged residues in the extracellular domain of an epithelial sodium channel (ENaC) subunit by alanine mutagenesis. Am J Physiol Renal Physiol. 2011 Apr;300(4):F887-97. doi: 10.1152/ajprenal.00648.2010. Epub 2011 Jan 5. PubMed PMID: 21209000.

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Laish-Farkash A, Glikson M, Brass D, Marek-Yagel D, Pras E, Dascal N, Antzelevitch C, Nof E, Reznik H, Eldar M, Luria D. A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews. J Cardiovasc Electrophysiol. 2010 Dec;21(12):1365-72. doi: 10.1111/j.1540-8167.2010.01844.x. PubMed PMID: 20662977; PubMed Central PMCID: PMC3005590.

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Tselnicker I, Dascal N. Further characterization of regulation of Ca(V)2.2 by stargazin. Channels (Austin). 2010 Sep-Oct;4(5):351-4. doi: 10.4161/chan.4.5.13504. PubMed PMID: 21139418.

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Tselnicker I, Tsemakhovich VA, Dessauer CW, Dascal N. Stargazin modulates neuronal voltage-dependent Ca(2+) channel Ca(v)2.2 by a Gbetagamma-dependent mechanism. J Biol Chem. 2010 Jul 2;285(27):20462-71. doi: 10.1074/jbc.M110.121277. Epub 2010 Apr 30. PubMed PMID: 20435886; PubMed Central PMCID: PMC2898357.

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Edelheit O, Hanukoglu I, Shriki Y, Tfilin M, Dascal N, Gillis D, Hanukoglu A. Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC. J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):84-8. doi: 10.1016/j.jsbmb.2010.01.002. Epub 2010 Jan 12. PubMed PMID: 20064610.

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Berlin S, Keren-Raifman T, Castel R, Rubinstein M, Dessauer CW, Ivanina T, Dascal N. G alpha(i) and G betagamma jointly regulate the conformations of a G betagamma effector, the neuronal G protein-activated K+ channel (GIRK). J Biol Chem. 2010 Feb 26;285(9):6179-85. doi: 10.1074/jbc.M109.085944. Epub 2009 Dec 16. PubMed PMID: 20018875; PubMed Central PMCID: PMC2825413.

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Babai N, Kanevsky N, Dascal N, Rozanski GJ, Singh DP, Fatma N, Thoreson WB. Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells. PLoS One. 2010 Jan 6;5(1):e8602. doi: 10.1371/journal.pone.0008602. PubMed PMID: 20066046; PubMed Central PMCID: PMC2798859.

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Sadana R, Dascal N, Dessauer CW. N terminus of type 5 adenylyl cyclase scaffolds Gs heterotrimer. Mol Pharmacol. 2009 Dec;76(6):1256-64. doi: 10.1124/mol.109.058370. Epub 2009 Sep 25. PubMed PMID: 19783621; PubMed Central PMCID: PMC2784731.

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Benmocha A, Almagor L, Oz S, Hirsch JA, Dascal N. Characterization of the calmodulin-binding site in the N terminus of CaV1.2. Channels (Austin). 2009 Sep-Oct;3(5):337-42. doi: 10.4161/chan.3.5.9686. Epub 2009 Sep 29. PubMed PMID: 19713738.

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Rubinstein M, Peleg S, Berlin S, Brass D, Keren-Raifman T, Dessauer CW, Ivanina T, Dascal N. Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by GalphaiGDP and Gbetagamma. J Physiol. 2009 Jul 15;587(Pt 14):3473-91. doi: 10.1113/jphysiol.2009.173229. Epub 2009 May 26. PubMed PMID: 19470775; PubMed Central PMCID: PMC2742276.

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Yakubovich D, Rishal I, Dessauer CW, Dascal N. Amplitude histogram-based method of analysis of patch clamp recordings that involve extreme changes in channel activity levels. J Mol Neurosci. 2009 Mar;37(3):201-11. doi: 10.1007/s12031-008-9117-z. Epub 2008 Jul 12. PubMed PMID: 18622586; PubMed Central PMCID: PMC2832599.

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Hanukoglu A, Edelheit O, Shriki Y, Gizewska M, Dascal N, Hanukoglu I. Renin-aldosterone response, urinary Na/K ratio and growth in pseudohypoaldosteronism patients with mutations in epithelial sodium channel (ENaC) subunit genes. J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):268-74. doi: 10.1016/j.jsbmb.2008.06.013. Epub 2008 Jun 26. PubMed PMID: 18634878.

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Kupchik YM, Rashkovan G, Ohana L, Keren-Raifman T, Dascal N, Parnas H, Parnas I. Molecular mechanisms that control initiation and termination of physiological depolarization-evoked transmitter release. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4435-40. doi: 10.1073/pnas.0708540105. Epub 2008 Mar 7. PubMed PMID: 18326630; PubMed Central PMCID: PMC2393753.

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Gibor G, Yakubovich D, Rosenhouse-Dantsker A, Peretz A, Schottelndreier H, Seebohm G, Dascal N, Logothetis DE, Paas Y, Attali B. An inactivation gate in the selectivity filter of KCNQ1 potassium channels. Biophys J. 2007 Dec 15;93(12):4159-72. doi: 10.1529/biophysj.107.107987. Epub 2007 Aug 17. PubMed PMID: 17704175; PubMed Central PMCID: PMC2098732.

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Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H, Pras E, Dascal N, Eldar M, Glikson M. Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia. Circulation. 2007 Jul 31;116(5):463-70. doi: 10.1161/CIRCULATIONAHA.107.706887. Epub 2007 Jul 23. PubMed PMID: 17646576.

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Rubinstein M, Peleg S, Berlin S, Brass D, Dascal N. Galphai3 primes the G protein-activated K+ channels for activation by coexpressed Gbetagamma in intact Xenopus oocytes. J Physiol. 2007 May 15;581(Pt 1):17-32. doi: 10.1113/jphysiol.2006.125864. Epub 2007 Feb 8. PubMed PMID: 17289785; PubMed Central PMCID: PMC2075207.

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Ben-Chaim Y, Chanda B, Dascal N, Bezanilla F, Parnas I, Parnas H. Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor. Nature. 2006 Nov 2;444(7115):106-9. doi: 10.1038/nature05259. Epub 2006 Oct 25. PubMed PMID: 17065983.

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Kanevsky N, Dascal N. Regulation of maximal open probability is a separable function of Ca(v)beta subunit in L-type Ca2+ channel, dependent on NH2 terminus of alpha1C (Ca(v)1.2alpha). J Gen Physiol. 2006 Jul;128(1):15-36. doi: 10.1085/jgp.200609485. PubMed PMID: 16801381; PubMed Central PMCID: PMC2151559.