My Bibliography

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Zheng L, Han X, Yao S, Zhu Y, Klement J, Wu S, Ji L, Zhu G, Cheng X, Tobiasova Z, Yu W, Huang B, Vesely MD, Wang J, Zhang J, Quinlan E, Chen L. The CD8α-PILRα interaction maintains CD8(+) T cell quiescence. Science. 2022 May 27;376(6596):996-1001. doi: 10.1126/science.aaz8658. Epub 2022 May 26. PubMed PMID: 35617401.

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Piper M, Van Court B, Mueller A, Watanabe S, Bickett T, Bhatia S, Darragh LB, Mayeda M, Nguyen D, Gadwa J, Knitz M, Corbo S, Morgan R, Lee JJ, Dent A, Goodman K, Messersmith W, Schulick R, Del Chiaro M, Zhu Y, Kedl RM, Lenz L, Karam SD. Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma. Clin Cancer Res. 2022 Mar 1;28(5):1013-1026. doi: 10.1158/1078-0432.CCR-21-2767. PubMed PMID: 34862244; PubMed Central PMCID: PMC8898296.

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Torphy RJ, Sun Y, Lin R, Caffrey-Carr A, Fujiwara Y, Ho F, Miller EN, McCarter MD, Lyons TR, Schulick RD, Kedl RM, Zhu Y. GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models. Nat Commun. 2022 Jan 10;13(1):97. doi: 10.1038/s41467-021-27658-x. PubMed PMID: 35013216; PubMed Central PMCID: PMC8748779.

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Fujiwara Y, Torphy RJ, Sun Y, Miller EN, Ho F, Borcherding N, Wu T, Torres RM, Zhang W, Schulick RD, Zhu Y. The GPR171 pathway suppresses T cell activation and limits antitumor immunity. Nat Commun. 2021 Oct 6;12(1):5857. doi: 10.1038/s41467-021-26135-9. PubMed PMID: 34615877; PubMed Central PMCID: PMC8494883.

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Kim MC, Borcherding N, Ahmed KK, Voigt AP, Vishwakarma A, Kolb R, Kluz PN, Pandey G, De U, Drashansky T, Helm EY, Zhang X, Gibson-Corley KN, Klesney-Tait J, Zhu Y, Lu J, Lu J, Huang X, Xiang H, Cheng J, Wang D, Wang Z, Tang J, Hu J, Wang Z, Liu H, Li M, Zhuang H, Avram D, Zhou D, Bacher R, Zheng SG, Wu X, Zakharia Y, Zhang W. CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. Nat Commun. 2021 Oct 1;12(1):5764. doi: 10.1038/s41467-021-26091-4. PubMed PMID: 34599187; PubMed Central PMCID: PMC8486774.

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Sun Y, Chen W, Torphy RJ, Yao S, Zhu G, Lin R, Lugano R, Miller EN, Fujiwara Y, Bian L, Zheng L, Anand S, Gao F, Zhang W, Ferrara SE, Goodspeed AE, Dimberg A, Wang XJ, Edil BH, Barnett CC, Schulick RD, Chen L, Zhu Y. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Sci Transl Med. 2021 Jul 28;13(604). doi: 10.1126/scitranslmed.abc8922. PubMed PMID: 34321321; PubMed Central PMCID: PMC8749958.

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Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8(+) T cells. Nat Immunol. 2021 Mar;22(3):370-380. doi: 10.1038/s41590-021-00868-7. Epub 2021 Feb 11. PubMed PMID: 33574619; PubMed Central PMCID: PMC7906956.

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Halpern AL, Fitz JG, Fujiwara Y, Yi J, Anderson AL, Zhu Y, Schulick RD, El Kasmi KC, Barnett CC Jr. Hepatic thermal injury promotes colorectal cancer engraftment in C57/black 6 mice. Am J Physiol Cell Physiol. 2021 Jan 1;320(1):C142-C151. doi: 10.1152/ajpcell.00071.2020. Epub 2020 Nov 11. PubMed PMID: 33175574; PubMed Central PMCID: PMC7846977.

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Torphy RJ, Schulick RD, Zhu Y. Understanding the immune landscape and tumor microenvironment of pancreatic cancer to improve immunotherapy. Mol Carcinog. 2020 Jul;59(7):775-782. doi: 10.1002/mc.23179. Epub 2020 Mar 12. Review. PubMed PMID: 32166821.

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Ma J, Liu F, Sheu WC, Meng Z, Xie Y, Xu H, Li M, Chen AT, Liu J, Bao Y, Zhang X, Zhang S, Zhang L, Zou Z, Wu H, Wang H, Zhu Y, Zhou J. Copresentation of Tumor Antigens and Costimulatory Molecules via Biomimetic Nanoparticles for Effective Cancer Immunotherapy. Nano Lett. 2020 Jun 10;20(6):4084-4094. doi: 10.1021/acs.nanolett.9b05171. Epub 2020 May 14. PubMed PMID: 32379462.

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Jin T, Wang C, Tian Y, Dai C, Zhu Y, Xu F. Mitochondrial metabolic reprogramming: An important player in liver cancer progression. Cancer Lett. 2020 Feb 1;470:197-203. doi: 10.1016/j.canlet.2019.11.029. Epub 2019 Nov 26. Review. PubMed PMID: 31783085.

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Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, Liu LZ, Ge X, Jiang BH, Gibson-Corley K, Klingelhutz A, Tan NS, Zhu Y, Sutterwala FS, Shen X, Zhang W. Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Oncogene. 2019 Mar;38(13):2351-2363. doi: 10.1038/s41388-018-0592-6. Epub 2018 Dec 5. PubMed PMID: 30518876; PubMed Central PMCID: PMC6440811.

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Tian Y, Sun Y, Gao F, Koenig MR, Sunderland A, Fujiwara Y, Torphy RJ, Chen L, Edil BH, Schulick RD, Zhu Y. CD28H expression identifies resident memory CD8 + T cells with less cytotoxicity in human peripheral tissues and cancers. Oncoimmunology. 2019;8(2):e1538440. doi: 10.1080/2162402X.2018.1538440. eCollection 2019. PubMed PMID: 30713797; PubMed Central PMCID: PMC6343811.

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Fujiwara Y, Sun Y, Torphy RJ, He J, Yanaga K, Edil BH, Schulick RD, Zhu Y. Pomalidomide Inhibits PD-L1 Induction to Promote Antitumor Immunity. Cancer Res. 2018 Dec 1;78(23):6655-6665. doi: 10.1158/0008-5472.CAN-18-1781. Epub 2018 Oct 12. PubMed PMID: 30315115.

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Borcherding N, Kolb R, Gullicksrud J, Vikas P, Zhu Y, Zhang W. Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer. J Mol Biol. 2018 Jul 6;430(14):2014-2029. doi: 10.1016/j.jmb.2018.05.030. Epub 2018 May 22. Review. PubMed PMID: 29800567; PubMed Central PMCID: PMC6071324.

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Torphy RJ, Zhu Y, Schulick RD. Immunotherapy for pancreatic cancer: Barriers and breakthroughs. Ann Gastroenterol Surg. 2018 Jul;2(4):274-281. doi: 10.1002/ags3.12176. eCollection 2018 Jul. Review. PubMed PMID: 30003190; PubMed Central PMCID: PMC6036358.

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Xu F, Jin T, Zhu Y, Dai C. Immune checkpoint therapy in liver cancer. J Exp Clin Cancer Res. 2018 May 29;37(1):110. doi: 10.1186/s13046-018-0777-4. Review. PubMed PMID: 29843754; PubMed Central PMCID: PMC5975687.

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Torphy RJ, Schulick RD, Zhu Y. Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy. Int J Mol Sci. 2017 Dec 6;18(12). doi: 10.3390/ijms18122642. Review. PubMed PMID: 29211042; PubMed Central PMCID: PMC5751245.

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Xu F, Sunderland A, Zhou Y, Schulick RD, Edil BH, Zhu Y. Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions. Cancer Immunol Immunother. 2017 Oct;66(10):1367-1375. doi: 10.1007/s00262-017-2031-x. Epub 2017 Jun 16. PubMed PMID: 28623459; PubMed Central PMCID: PMC5709220.

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Bastman JJ, Serracino HS, Zhu Y, Koenig MR, Mateescu V, Sams SB, Davies KD, Raeburn CD, McIntyre RC Jr, Haugen BR, French JD. Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer. J Clin Endocrinol Metab. 2016 Jul;101(7):2863-73. doi: 10.1210/jc.2015-4227. Epub 2016 Apr 5. PubMed PMID: 27045886; PubMed Central PMCID: PMC4929840.

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Zhu Y, Yao S, Augustine MM, Xu H, Wang J, Sun J, Broadwater M, Ruff W, Luo L, Zhu G, Tamada K, Chen L. Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM. Sci Adv. 2016 Apr;2(4):e1500637. doi: 10.1126/sciadv.1500637. eCollection 2016 Apr. PubMed PMID: 27152329; PubMed Central PMCID: PMC4846428.

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Zhu Y, Paniccia A, Schulick AC, Chen W, Koenig MR, Byers JT, Yao S, Bevers S, Edil BH. Identification of CD112R as a novel checkpoint for human T cells. J Exp Med. 2016 Feb 8;213(2):167-76. doi: 10.1084/jem.20150785. Epub 2016 Jan 11. PubMed PMID: 26755705; PubMed Central PMCID: PMC4749091.

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Byers JT, Paniccia A, Kaplan J, Koenig M, Kahn N, Wilson L, Chen L, Schulick RD, Edil BH, Zhu Y. Expression of the Novel Costimulatory Molecule B7-H5 in Pancreatic Cancer. Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1574-9. doi: 10.1245/s10434-014-4293-2. Epub 2014 Dec 18. PubMed PMID: 25519928.

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Yu X, Koenig MR, Zhu Y. Plasma miRNA, an emerging biomarker for pancreatic cancer. Ann Transl Med. 2015 Nov;3(19):297. doi: 10.3978/j.issn.2305-5839.2015.11.03. PubMed PMID: 26697457; PubMed Central PMCID: PMC4671870.

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Paniccia A, Merkow J, Edil BH, Zhu Y. Immunotherapy for pancreatic ductal adenocarcinoma: an overview of clinical trials. Chin J Cancer Res. 2015 Aug;27(4):376-91. doi: 10.3978/j.issn.1000-9604.2015.05.01. Review. PubMed PMID: 26361407; PubMed Central PMCID: PMC4560736.

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Luo L, Zhu G, Xu H, Yao S, Zhou G, Zhu Y, Tamada K, Huang L, Flies AD, Broadwater M, Ruff W, van Deursen JM, Melero I, Zhu Z, Chen L. B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets. PLoS One. 2015;10(6):e0130126. doi: 10.1371/journal.pone.0130126. eCollection 2015. PubMed PMID: 26065426; PubMed Central PMCID: PMC4465912.

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Zhu Y, Chen L. CD137 as a biomarker for tumor-reactive T cells: finding gold in the desert. Clin Cancer Res. 2014 Jan 1;20(1):3-5. doi: 10.1158/1078-0432.CCR-13-2573. Epub 2013 Oct 28. PubMed PMID: 24166912.

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Yao S, Zhu Y, Chen L. Advances in targeting cell surface signalling molecules for immune modulation. Nat Rev Drug Discov. 2013 Feb;12(2):130-46. doi: 10.1038/nrd3877. Review. PubMed PMID: 23370250; PubMed Central PMCID: PMC3698571.

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Zhu Y, Yao S, Iliopoulou BP, Han X, Augustine MM, Xu H, Phennicie RT, Flies SJ, Broadwater M, Ruff W, Taube JM, Zheng L, Luo L, Zhu G, Chen J, Chen L. B7-H5 costimulates human T cells via CD28H. Nat Commun. 2013;4:2043. doi: 10.1038/ncomms3043. PubMed PMID: 23784006; PubMed Central PMCID: PMC3698612.

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Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L. B7-h2 is a costimulatory ligand for CD28 in human. Immunity. 2011 May 27;34(5):729-40. doi: 10.1016/j.immuni.2011.03.014. Epub 2011 Apr 28. PubMed PMID: 21530327; PubMed Central PMCID: PMC3103603.

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Zhu Y, Yao S, Chen L. Cell surface signaling molecules in the control of immune responses: a tide model. Immunity. 2011 Apr 22;34(4):466-78. doi: 10.1016/j.immuni.2011.04.008. Review. PubMed PMID: 21511182; PubMed Central PMCID: PMC3176719.

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Narazaki H, Zhu Y, Luo L, Zhu G, Chen L. CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells. Blood. 2010 Mar 11;115(10):1941-8. doi: 10.1182/blood-2008-12-192591. Epub 2010 Jan 12. PubMed PMID: 20068221; PubMed Central PMCID: PMC2837330.

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Yao S, Wang S, Zhu Y, Luo L, Zhu G, Flies S, Xu H, Ruff W, Broadwater M, Choi IH, Tamada K, Chen L. PD-1 on dendritic cells impedes innate immunity against bacterial infection. Blood. 2009 Jun 4;113(23):5811-8. doi: 10.1182/blood-2009-02-203141. Epub 2009 Apr 1. PubMed PMID: 19339692; PubMed Central PMCID: PMC2700320.

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Zhu Y, Chen L. Turning the tide of lymphocyte costimulation. J Immunol. 2009 Mar 1;182(5):2557-8. doi: 10.4049/jimmunol.0990006. PubMed PMID: 19234146.

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Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 2008 Jan 25;319(5862):476-81. doi: 10.1126/science.1151227. PubMed PMID: 18218901; PubMed Central PMCID: PMC3602998.

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Zhu Y, Zhu G, Luo L, Flies AS, Chen L. CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood. 2007 Jun 1;109(11):4882-9. doi: 10.1182/blood-2006-10-043463. Epub 2007 Jan 23. PubMed PMID: 17244673; PubMed Central PMCID: PMC1885532.

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Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L. Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. J Immunol. 2003 Nov 1;171(9):4650-4. doi: 10.4049/jimmunol.171.9.4650. PubMed PMID: 14568939.

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Zhu Y, Chen L. Cancer therapeutic monoclonal antibodies targeting lymphocyte co-stimulatory pathways. Curr Opin Investig Drugs. 2003 Jun;4(6):691-5. Review. PubMed PMID: 12901227.