My Bibliography

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Yoshii A, McMillen TS, Wang Y, Zhou B, Chen H, Banerjee D, Herrero M, Wang P, Muraoka N, Wang W, Murry CE, Tian R. Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF. Circ Res. 2024 Oct 25;135(10):1004-1017. doi: 10.1161/CIRCRESAHA.123.324103. Epub 2024 Sep 27. PubMed PMID: 39328167; PubMed Central PMCID: PMC11502249.

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Walker MA, Tian R. NAD metabolism and heart failure: Mechanisms and therapeutic potentials. J Mol Cell Cardiol. 2024 Oct;195:45-54. doi: 10.1016/j.yjmcc.2024.07.008. Epub 2024 Aug 3. Review. PubMed PMID: 39096536; PubMed Central PMCID: PMC11390314.

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Bornstein MR, Tian R, Arany Z. Human cardiac metabolism. Cell Metab. 2024 Jul 2;36(7):1456-1481. doi: 10.1016/j.cmet.2024.06.003. Review. PubMed PMID: 38959861; PubMed Central PMCID: PMC11290709.

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Wang DD, Naumova AV, Isquith D, Sapp J, Huynh KA, Tucker I, Balu N, Voronyuk A, Chu B, Ordovas K, Maynard C, Tian R, Zhao XQ, Kim F. Dapagliflozin reduces systemic inflammation in patients with type 2 diabetes without known heart failure. Cardiovasc Diabetol. 2024 Jun 7;23(1):197. doi: 10.1186/s12933-024-02294-z. PubMed PMID: 38849829; PubMed Central PMCID: PMC11161924.

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Wu J, Bley M, Steans RS, Meadows AM, Huffstutler RD, Tian R, Griffin JL, Sack MN. Nicotinamide Riboside Augments Human Macrophage Migration via SIRT3-Mediated Prostaglandin E2 Signaling. Cells. 2024 Mar 5;13(5). doi: 10.3390/cells13050455. PubMed PMID: 38474420; PubMed Central PMCID: PMC10931126.

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Mohr JP, Caudal A, Tian R, Bruce JE. Multidimensional Cross-Linking and Real-Time Informatics for Multiprotein Interaction Studies. J Proteome Res. 2024 Jan 5;23(1):107-116. doi: 10.1021/acs.jproteome.3c00455. Epub 2023 Dec 26. PubMed PMID: 38147001; PubMed Central PMCID: PMC10906106.

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Walker MA, Chen H, Yadav A, Ritterhoff J, Villet O, McMillen T, Wang Y, Purcell H, Djukovic D, Raftery D, Isoherranen N, Tian R. Raising NAD(+) Level Stimulates Short-Chain Dehydrogenase/Reductase Proteins to Alleviate Heart Failure Independent of Mitochondrial Protein Deacetylation. Circulation. 2023 Dec 19;148(25):2038-2057. doi: 10.1161/CIRCULATIONAHA.123.066039. Epub 2023 Nov 15. PubMed PMID: 37965787; PubMed Central PMCID: PMC10842390.

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Ritterhoff J, Tian R. Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges. Nat Rev Cardiol. 2023 Dec;20(12):812-829. doi: 10.1038/s41569-023-00887-x. Epub 2023 May 26. Review. PubMed PMID: 37237146.

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Han K, Singh K, Meadows AM, Sharma R, Hassanzadeh S, Wu J, Goss-Holmes H, Huffstutler RD, Teague HL, Mehta NN, Griffin JL, Tian R, Traba J, Sack MN. Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects. Cell Rep Med. 2023 Sep 19;4(9):101157. doi: 10.1016/j.xcrm.2023.101157. Epub 2023 Aug 15. PubMed PMID: 37586364; PubMed Central PMCID: PMC10518596.

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Banerjee D, Tian R, Cai S. The Role of Innate Immune Cells in Cardiac Injury and Repair: A Metabolic Perspective. Curr Cardiol Rep. 2023 Jul;25(7):631-640. doi: 10.1007/s11886-023-01897-4. Epub 2023 May 30. Review. PubMed PMID: 37249739; PubMed Central PMCID: PMC10227821.

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Nishi K, Yoshii A, Abell L, Zhou B, Frausto R, Ritterhoff J, McMillen TS, Sweet I, Wang Y, Gao C, Tian R. Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes. Cell Rep. 2023 Jun 27;42(6):112641. doi: 10.1016/j.celrep.2023.112641. Epub 2023 Jun 12. PubMed PMID: 37310861; PubMed Central PMCID: PMC10592489.

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Nagana Gowda GA, Abell L, Tian R, Raftery D. Whole Body Distribution of Labile Coenzymes and Antioxidants in a Mouse Model as Visualized Using (1)H NMR Spectroscopy. Anal Chem. 2023 Apr 11;95(14):6029-6037. doi: 10.1021/acs.analchem.3c00054. Epub 2023 Mar 29. PubMed PMID: 36988554; PubMed Central PMCID: PMC10089975.

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Cai S, Zhao M, Zhou B, Yoshii A, Bugg D, Villet O, Sahu A, Olson GS, Davis J, Tian R. Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction. J Clin Invest. 2023 Feb 15;133(4). doi: 10.1172/JCI159498. PubMed PMID: 36480284; PubMed Central PMCID: PMC9927948.

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Mhatre KN, Murray JD, Flint G, McMillen TS, Weber G, Shakeri M, Tu AY, Steczina S, Weiss R, Marcinek DJ, Murry CE, Raftery D, Tian R, Moussavi-Harami F, Regnier M. dATP elevation induces myocardial metabolic remodeling to support improved cardiac function. J Mol Cell Cardiol. 2023 Feb;175:1-12. doi: 10.1016/j.yjmcc.2022.11.010. Epub 2022 Dec 5. PubMed PMID: 36470336; PubMed Central PMCID: PMC9974746.

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Cheng YY, Gregorich Z, Prajnamitra RP, Lundy DJ, Ma TY, Huang YH, Lee YC, Ruan SC, Lin JH, Lin PJ, Kuo CW, Chen P, Yan YT, Tian R, Kamp TJ, Hsieh PCH. Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration. Circulation. 2022 Dec 20;146(25):1950-1967. doi: 10.1161/CIRCULATIONAHA.122.061960. Epub 2022 Nov 24. PubMed PMID: 36420731; PubMed Central PMCID: PMC9808601.

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Wang DD, Airhart SE, Zhou B, Shireman LM, Jiang S, Melendez Rodriguez C, Kirkpatrick JN, Shen DD, Tian R, O'Brien KD. Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction. JACC Basic Transl Sci. 2022 Dec;7(12):1183-1196. doi: 10.1016/j.jacbts.2022.06.012. eCollection 2022 Dec. PubMed PMID: 36644285; PubMed Central PMCID: PMC9831861.

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O'Brien KD. Lipoproteins and Calcific Aortic Valve Disease: Hardening Evidence?. Arterioscler Thromb Vasc Biol. 2022 Nov;42(11):1321-1323. doi: 10.1161/ATVBAHA.122.318310. Epub 2022 Sep 22. PubMed PMID: 36134565; PubMed Central PMCID: PMC9613592.

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Bravo CA, Navarro AG, Dhaliwal KK, Khorsandi M, Keenan JE, Mudigonda P, O'Brien KD, Mahr C. Right heart failure after left ventricular assist device: From mechanisms to treatments. Front Cardiovasc Med. 2022;9:1023549. doi: 10.3389/fcvm.2022.1023549. eCollection 2022. Review. PubMed PMID: 36337897; PubMed Central PMCID: PMC9626829.

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Caudal A, Tang X, Chavez JD, Keller A, Mohr JP, Bakhtina AA, Villet O, Chen H, Zhou B, Walker MA, Tian R, Bruce JE. Mitochondrial interactome quantitation reveals structural changes in metabolic machinery in the failing murine heart. Nat Cardiovasc Res. 2022 Sep;1(9):855-866. doi: 10.1038/s44161-022-00127-4. Epub 2022 Sep 9. PubMed PMID: 36405497; PubMed Central PMCID: PMC9667921.

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Zhou B, Caudal A, Tang X, Chavez JD, McMillen TS, Keller A, Villet O, Zhao M, Liu Y, Ritterhoff J, Wang P, Kolwicz SC Jr, Wang W, Bruce JE, Tian R. Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts. J Clin Invest. 2022 May 16;132(10). doi: 10.1172/JCI155333. PubMed PMID: 35575090; PubMed Central PMCID: PMC9106352.

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Wang P, Xu S, Xu J, Xin Y, Lu Y, Zhang H, Zhou B, Xu H, Sheu SS, Tian R, Wang W. Elevated MCU Expression by CaMKIIδB Limits Pathological Cardiac Remodeling. Circulation. 2022 Apr 5;145(14):1067-1083. doi: 10.1161/CIRCULATIONAHA.121.055841. Epub 2022 Feb 15. PubMed PMID: 35167328; PubMed Central PMCID: PMC8983595.

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Matsuura Y, Shimizu-Albergine M, Barnhart S, Kramer F, Hsu CC, Kothari V, Tang J, Gharib SA, Kanter JE, Abel ED, Tian R, Shao B, Bornfeldt KE. Diabetes Suppresses Glucose Uptake and Glycolysis in Macrophages. Circ Res. 2022 Mar 4;130(5):779-781. doi: 10.1161/CIRCRESAHA.121.320060. Epub 2022 Feb 16. PubMed PMID: 35170337; PubMed Central PMCID: PMC8897241.

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Wu J, Singh K, Lin A, Meadows AM, Wu K, Shing V, Bley M, Hassanzadeh S, Huffstutler RD, Schmidt MS, Blanco LP, Tian R, Brenner C, Pirooznia M, Kaplan MJ, Sack MN. Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes. J Clin Invest. 2022 Mar 1;132(5). doi: 10.1172/JCI139828. PubMed PMID: 35025762; PubMed Central PMCID: PMC8884917.

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Miklas JW, Levy S, Hofsteen P, Mex DI, Clark E, Muster J, Robitaille AM, Sivaram G, Abell L, Goodson JM, Pranoto I, Madan A, Chin MT, Tian R, Murry CE, Moon RT, Wang Y, Ruohola-Baker H. Amino acid primed mTOR activity is essential for heart regeneration. iScience. 2022 Jan 21;25(1):103574. doi: 10.1016/j.isci.2021.103574. eCollection 2022 Jan 21. PubMed PMID: 34988408; PubMed Central PMCID: PMC8704488.

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Hu Q, Wu D, Walker M, Wang P, Tian R, Wang W. Genetically encoded biosensors for evaluating NAD(+)/NADH ratio in cytosolic and mitochondrial compartments. Cell Rep Methods. 2021 Nov 22;1(7). doi: 10.1016/j.crmeth.2021.100116. Epub 2021 Nov 15. PubMed PMID: 34901920; PubMed Central PMCID: PMC8659198.

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Nakamura K, Neidig LE, Yang X, Weber GJ, El-Nachef D, Tsuchida H, Dupras S, Kalucki FA, Jayabalu A, Futakuchi-Tsuchida A, Nakamura DS, Marchianò S, Bertero A, Robinson MR, Cain K, Whittington D, Tian R, Reinecke H, Pabon L, Knollmann BC, Kattman S, Thies RS, MacLellan WR, Murry CE. Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes. Stem Cell Reports. 2021 Oct 12;16(10):2473-2487. doi: 10.1016/j.stemcr.2021.08.005. Epub 2021 Sep 9. PubMed PMID: 34506727; PubMed Central PMCID: PMC8514851.

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O'Brien KD, Tian R. Boosting mitochondrial metabolism with dietary supplements in heart failure. Nat Rev Cardiol. 2021 Oct;18(10):685-686. doi: 10.1038/s41569-021-00610-8. PubMed PMID: 34404939; PubMed Central PMCID: PMC9172082.

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Wang DD, Cheng RK, Tian R. Combat Doxorubicin Cardiotoxicity With the Power of Mitochondria Transfer. JACC CardioOncol. 2021 Sep;3(3):441-443. doi: 10.1016/j.jaccao.2021.08.001. eCollection 2021 Sep. PubMed PMID: 34604805; PubMed Central PMCID: PMC8463719.

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Ritterhoff J, McMillen TS, Villet O, Young S, Kolwicz SC Jr, Senn T, Caudal A, Tian R. Increasing fatty acid oxidation elicits a sex-dependent response in failing mouse hearts. J Mol Cell Cardiol. 2021 Sep;158:1-10. doi: 10.1016/j.yjmcc.2021.05.004. Epub 2021 May 12. PubMed PMID: 33989657; PubMed Central PMCID: PMC8405556.

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Chiao YA, Chakraborty AD, Light CM, Tian R, Sadoshima J, Shi X, Gu H, Lee CF. NAD(+) Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy. Circ Heart Fail. 2021 Aug;14(8):e008170. doi: 10.1161/CIRCHEARTFAILURE.120.008170. Epub 2021 Aug 10. PubMed PMID: 34374300; PubMed Central PMCID: PMC8373812.

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Schiattarella GG, Wang Y, Tian R, Hill JA. Metabolism and Inflammation in Cardiovascular Health and Diseases: Mechanisms to Therapies. J Mol Cell Cardiol. 2021 Aug;157:113-114. doi: 10.1016/j.yjmcc.2021.02.011. Epub 2021 Mar 2. PubMed PMID: 33667418; PubMed Central PMCID: PMC8319053.

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Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED. Cardiac Energy Metabolism in Heart Failure. Circ Res. 2021 May 14;128(10):1487-1513. doi: 10.1161/CIRCRESAHA.121.318241. Epub 2021 May 13. Review. PubMed PMID: 33983836; PubMed Central PMCID: PMC8136750.

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Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, Tian R, Lien CL, Pellegrini M, Christofk H, Nakano H, Nakano A. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep. 2021 Apr 21;11(1):8669. doi: 10.1038/s41598-021-88159-x. PubMed PMID: 33883682; PubMed Central PMCID: PMC8060418.

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Walker MA, Chavez J, Villet O, Tang X, Keller A, Bruce JE, Tian R. Acetylation of muscle creatine kinase negatively impacts high-energy phosphotransfer in heart failure. JCI Insight. 2021 Feb 8;6(3). doi: 10.1172/jci.insight.144301. PubMed PMID: 33554956; PubMed Central PMCID: PMC7934860.

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Zhou B, Wang DD, Qiu Y, Airhart S, Liu Y, Stempien-Otero A, O'Brien KD, Tian R. Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure. J Clin Invest. 2020 Nov 2;130(11):6054-6063. doi: 10.1172/JCI138538. PubMed PMID: 32790648; PubMed Central PMCID: PMC7598081.

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Shao D, Kolwicz SC Jr, Wang P, Roe ND, Villet O, Nishi K, Hsu YA, Flint GV, Caudal A, Wang W, Regnier M, Tian R. Increasing Fatty Acid Oxidation Prevents High-Fat Diet-Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy. Circulation. 2020 Sep 8;142(10):983-997. doi: 10.1161/CIRCULATIONAHA.119.043319. Epub 2020 Jun 29. PubMed PMID: 32597196; PubMed Central PMCID: PMC7484440.

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Liu Z, Ding J, McMillen TS, Villet O, Tian R, Shao D. Enhancing fatty acid oxidation negatively regulates PPARs signaling in the heart. J Mol Cell Cardiol. 2020 Sep;146:1-11. doi: 10.1016/j.yjmcc.2020.06.008. Epub 2020 Jun 24. PubMed PMID: 32592696; PubMed Central PMCID: PMC7494556.

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Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 Jul 1;39(13):e104073. doi: 10.15252/embj.2019104073. Epub 2020 May 20. PubMed PMID: 32432379; PubMed Central PMCID: PMC7327496.

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Hu Q, Zhang H, Gutiérrez Cortés N, Wu D, Wang P, Zhang J, Mattison JA, Smith E, Bettcher LF, Wang M, Lakatta EG, Sheu SS, Wang W. Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction. Circ Res. 2020 Feb 14;126(4):456-470. doi: 10.1161/CIRCRESAHA.119.315252. Epub 2020 Jan 3. PubMed PMID: 31896304; PubMed Central PMCID: PMC7035202.

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Ritterhoff J, Young S, Villet O, Shao D, Neto FC, Bettcher LF, Hsu YA, Kolwicz SC Jr, Raftery D, Tian R. Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis. Circ Res. 2020 Jan 17;126(2):182-196. doi: 10.1161/CIRCRESAHA.119.315483. Epub 2019 Nov 11. PubMed PMID: 31709908; PubMed Central PMCID: PMC8448129.

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Jung HS, Shimizu-Albergine M, Shen X, Kramer F, Shao D, Vivekanandan-Giri A, Pennathur S, Tian R, Kanter JE, Bornfeldt KE. TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells. J Lipid Res. 2020 Jan;61(1):33-44. doi: 10.1194/jlr.RA119000256. Epub 2019 Nov 13. PubMed PMID: 31722970; PubMed Central PMCID: PMC6939593.

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Chavez JD, Keller A, Zhou B, Tian R, Bruce JE. Cellular Interactome Dynamics during Paclitaxel Treatment. Cell Rep. 2019 Nov 19;29(8):2371-2383.e5. doi: 10.1016/j.celrep.2019.10.063. PubMed PMID: 31747606; PubMed Central PMCID: PMC6910234.

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Yang X, Rodriguez ML, Leonard A, Sun L, Fischer KA, Wang Y, Ritterhoff J, Zhao L, Kolwicz SC Jr, Pabon L, Reinecke H, Sniadecki NJ, Tian R, Ruohola-Baker H, Xu H, Murry CE. Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells. Stem Cell Reports. 2019 Oct 8;13(4):657-668. doi: 10.1016/j.stemcr.2019.08.013. Epub 2019 Sep 26. PubMed PMID: 31564645; PubMed Central PMCID: PMC6829750.

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Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW II, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O'Brien KD, O'Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L. Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop. Circulation. 2019 Oct 1;140(14):1205-1216. doi: 10.1161/CIRCULATIONAHA.119.040551. Review. PubMed PMID: 31769940; PubMed Central PMCID: PMC6880654.

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Lee CF, Caudal A, Abell L, Nagana Gowda GA, Tian R. Targeting NAD(+) Metabolism as Interventions for Mitochondrial Disease. Sci Rep. 2019 Feb 28;9(1):3073. doi: 10.1038/s41598-019-39419-4. PubMed PMID: 30816177; PubMed Central PMCID: PMC6395802.

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Nagana Gowda GA, Abell L, Tian R. Extending the Scope of (1)H NMR Spectroscopy for the Analysis of Cellular Coenzyme A and Acetyl Coenzyme A. Anal Chem. 2019 Feb 5;91(3):2464-2471. doi: 10.1021/acs.analchem.8b05286. Epub 2019 Jan 17. PubMed PMID: 30608643; PubMed Central PMCID: PMC6810604.

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Zhang H, Gong G, Wang P, Zhang Z, Kolwicz SC, Rabinovitch PS, Tian R, Wang W. Heart specific knockout of Ndufs4 ameliorates ischemia reperfusion injury. J Mol Cell Cardiol. 2018 Oct;123:38-45. doi: 10.1016/j.yjmcc.2018.08.022. Epub 2018 Aug 27. PubMed PMID: 30165037; PubMed Central PMCID: PMC6192835.

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Zhou B, Tian R. Mitochondrial dysfunction in pathophysiology of heart failure. J Clin Invest. 2018 Aug 31;128(9):3716-3726. doi: 10.1172/JCI120849. Epub 2018 Aug 20. Review. PubMed PMID: 30124471; PubMed Central PMCID: PMC6118589.

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Shao D, Villet O, Zhang Z, Choi SW, Yan J, Ritterhoff J, Gu H, Djukovic D, Christodoulou D, Kolwicz SC Jr, Raftery D, Tian R. Glucose promotes cell growth by suppressing branched-chain amino acid degradation. Nat Commun. 2018 Jul 26;9(1):2935. doi: 10.1038/s41467-018-05362-7. PubMed PMID: 30050148; PubMed Central PMCID: PMC6062555.

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Walker MA, Tian R. NAD(H) in mitochondrial energy transduction: implications for health and disease. Curr Opin Physiol. 2018 Jun;3:101-109. doi: 10.1016/j.cophys.2018.03.011. Epub 2018 Apr 11. PubMed PMID: 32258851; PubMed Central PMCID: PMC7112453.