My Bibliography

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Jiang L, Liu Y, Tumbath S, Boudreau MW, Chatkewitz LE, Wang J, Su X, Zahid KR, Li K, Chen Y, Yang K, Hergenrother PJ, Huang X. Isopentyl-Deoxynboquinone Induces Mitochondrial Dysfunction and G2/M Phase Cell Cycle Arrest to Selectively Kill NQO1-Positive Pancreatic Cancer Cells. Antioxid Redox Signal. 2024 Jul;41(1-3):74-92. doi: 10.1089/ars.2022.0224. Epub 2024 Jan 8. PubMed PMID: 37950707; PubMed Central PMCID: PMC11321107.

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Tikka C, Beasley L, Xu C, Yang J, Cooper S, Lechner J, Gutch S, Kaplan MH, Capitano M, Yang K. BATF sustains homeostasis and functionality of bone marrow Treg cells to preserve homeostatic regulation of hematopoiesis and development of B cells. Front Immunol. 2023;14:1026368. doi: 10.3389/fimmu.2023.1026368. eCollection 2023. PubMed PMID: 36911703; PubMed Central PMCID: PMC9992736.

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Blanco DB, Chapman NM, Raynor JL, Xu C, Su W, Kc A, Li W, Lim SA, Schattgen S, Shi H, Risch I, Sun Y, Dhungana Y, Kim Y, Wei J, Rankin S, Neale G, Thomas PG, Yang K, Chi H. PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis. Nat Cell Biol. 2022 Nov;24(11):1642-1654. doi: 10.1038/s41556-022-01011-w. Epub 2022 Oct 27. PubMed PMID: 36302969; PubMed Central PMCID: PMC10080469.

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Fu Y, Pajulas A, Wang J, Zhou B, Cannon A, Cheung CCL, Zhang J, Zhou H, Fisher AJ, Omstead DT, Khan S, Han L, Renauld JC, Paczesny S, Gao H, Liu Y, Yang L, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Sun J, Bilgicer B, Sears CR, Yang K, Kaplan MH. Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. Nat Commun. 2022 Jul 1;13(1):3811. doi: 10.1038/s41467-022-31596-7. PubMed PMID: 35778404; PubMed Central PMCID: PMC9249769.

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Yang K. Regulation of Treg Cell Metabolism and Function in Non-Lymphoid Tissues. Front Immunol. 2022;13:909705. doi: 10.3389/fimmu.2022.909705. eCollection 2022. Review. PubMed PMID: 35720275; PubMed Central PMCID: PMC9200993.

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Li K, Wang AKY, Liu S, Fang S, Lu AZ, Shen J, Yang L, Hu CD, Yang K, Wan J. Advanced Functions Embedded in the Second Version of Database, Global Evaluation of SARS-CoV-2/hCoV-19 Sequences 2. Front Med (Lausanne). 2022;9:813964. doi: 10.3389/fmed.2022.813964. eCollection 2022. PubMed PMID: 35479940; PubMed Central PMCID: PMC9037956.

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Xu C, Sun S, Johnson T, Qi R, Zhang S, Zhang J, Yang K. The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity. Cell Rep. 2021 Jun 15;35(11):109235. doi: 10.1016/j.celrep.2021.109235. PubMed PMID: 34133924.

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Xu C, Fu Y, Liu S, Trittipo J, Lu X, Qi R, Du H, Yan C, Zhang C, Wan J, Kaplan MH, Yang K. BATF Regulates T Regulatory Cell Functional Specification and Fitness of Triglyceride Metabolism in Restraining Allergic Responses. J Immunol. 2021 May 1;206(9):2088-2100. doi: 10.4049/jimmunol.2001184. Epub 2021 Apr 19. PubMed PMID: 33879580; PubMed Central PMCID: PMC8442614.

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Johnson TS, Xiang S, Dong T, Huang Z, Cheng M, Wang T, Yang K, Ni D, Huang K, Zhang J. Combinatorial analyses reveal cellular composition changes have different impacts on transcriptomic changes of cell type specific genes in Alzheimer's Disease. Sci Rep. 2021 Jan 11;11(1):353. doi: 10.1038/s41598-020-79740-x. PubMed PMID: 33432017; PubMed Central PMCID: PMC7801680.

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Golomb SM, Guldner IH, Zhao A, Wang Q, Palakurthi B, Aleksandrovic EA, Lopez JA, Lee SW, Yang K, Zhang S. Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis. Cell Rep. 2020 Dec 1;33(9):108438. doi: 10.1016/j.celrep.2020.108438. PubMed PMID: 33264626; PubMed Central PMCID: PMC7737488.

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Fu Y, Wang J, Panangipalli G, Ulrich BJ, Koh B, Xu C, Kharwadkar R, Chu X, Wang Y, Gao H, Wu W, Sun J, Tepper RS, Zhou B, Janga SC, Yang K, Kaplan MH. STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus. Nat Commun. 2020 Sep 28;11(1):4882. doi: 10.1038/s41467-020-18648-6. PubMed PMID: 32985505; PubMed Central PMCID: PMC7523001.

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Xie MM, Chen Q, Liu H, Yang K, Koh B, Wu H, Maleki SJ, Hurlburt BK, Cook-Mills J, Kaplan MH, Dent AL. T follicular regulatory cells and IL-10 promote food antigen-specific IgE. J Clin Invest. 2020 Jul 1;130(7):3820-3832. doi: 10.1172/JCI132249. PubMed PMID: 32255767; PubMed Central PMCID: PMC7324176.

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Yang K, Chi H. Autophagy modulates CD4(+) T-cell lineage recommitment upon pathogen infection. Cell Mol Immunol. 2020 Jul;17(7):682-683. doi: 10.1038/s41423-020-0368-0. Epub 2020 Feb 11. PubMed PMID: 32047257; PubMed Central PMCID: PMC7331744.

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Wang J, Kaplan MH, Yang K. ResTORing barrier function in the skin. J Allergy Clin Immunol. 2020 Jan;145(1):111-113. doi: 10.1016/j.jaci.2019.10.007. Epub 2019 Oct 22. PubMed PMID: 31647965.

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Karmaus PWF, Chen X, Lim SA, Herrada AA, Nguyen TM, Xu B, Dhungana Y, Rankin S, Chen W, Rosencrance C, Yang K, Fan Y, Cheng Y, Easton J, Neale G, Vogel P, Chi H. Metabolic heterogeneity underlies reciprocal fates of T(H)17 cell stemness and plasticity. Nature. 2019 Jan;565(7737):101-105. doi: 10.1038/s41586-018-0806-7. Epub 2018 Dec 19. PubMed PMID: 30568299; PubMed Central PMCID: PMC6420879.

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Yang K, Blanco DB, Chen X, Dash P, Neale G, Rosencrance C, Easton J, Chen W, Cheng C, Dhungana Y, Kc A, Awad W, Guo XJ, Thomas PG, Chi H. Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells. Sci Immunol. 2018 Jul 6;3(25). doi: 10.1126/sciimmunol.aas9818. PubMed PMID: 29980617; PubMed Central PMCID: PMC6230375.

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Yang K, Chi H. Investigating Cellular Quiescence of T Lymphocytes and Antigen-Induced Exit from Quiescence. Methods Mol Biol. 2018;1686:161-172. doi: 10.1007/978-1-4939-7371-2_12. PubMed PMID: 29030820.

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Yang K, Blanco DB, Neale G, Vogel P, Avila J, Clish CB, Wu C, Shrestha S, Rankin S, Long L, Kc A, Chi H. Homeostatic control of metabolic and functional fitness of T(reg) cells by LKB1 signalling. Nature. 2017 Aug 31;548(7669):602-606. doi: 10.1038/nature23665. Epub 2017 Aug 23. PubMed PMID: 28847007; PubMed Central PMCID: PMC5804356.

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Tan H, Yang K, Li Y, Shaw TI, Wang Y, Blanco DB, Wang X, Cho JH, Wang H, Rankin S, Guy C, Peng J, Chi H. Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation. Immunity. 2017 Mar 21;46(3):488-503. doi: 10.1016/j.immuni.2017.02.010. Epub 2017 Mar 9. PubMed PMID: 28285833; PubMed Central PMCID: PMC5466820.

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Wei J, Long L, Yang K, Guy C, Shrestha S, Chen Z, Wu C, Vogel P, Neale G, Green DR, Chi H. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nat Immunol. 2016 Mar;17(3):277-85. doi: 10.1038/ni.3365. Epub 2016 Jan 25. PubMed PMID: 26808230; PubMed Central PMCID: PMC4755832.

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Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat Immunol. 2015 Feb;16(2):178-87. doi: 10.1038/ni.3076. Epub 2015 Jan 5. PubMed PMID: 25559258; PubMed Central PMCID: PMC4297581.

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Yang K, Chi H. AMPK helps T cells survive nutrient starvation. Immunity. 2015 Jan 20;42(1):4-6. doi: 10.1016/j.immuni.2014.12.029. PubMed PMID: 25607450.

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Wei J, Yang K, Chi H. Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision. J Immunol. 2014 Nov 1;193(9):4297-4301. doi: 10.4049/jimmunol.1402042. Epub 2014 Sep 26. PubMed PMID: 25261481; PubMed Central PMCID: PMC4201958.

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Shrestha S, Yang K, Wei J, Karmaus PW, Neale G, Chi H. Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14858-63. doi: 10.1073/pnas.1404264111. Epub 2014 Sep 30. PubMed PMID: 25271321; PubMed Central PMCID: PMC4205612.

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Wu J, Yang J, Yang K, Wang H, Gorentla B, Shin J, Qiu Y, Que LG, Foster WM, Xia Z, Chi H, Zhong XP. iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. J Clin Invest. 2014 Apr;124(4):1685-98. doi: 10.1172/JCI69780. Epub 2014 Mar 10. PubMed PMID: 24614103; PubMed Central PMCID: PMC3973110.

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Yang K, Chi H. Metabolic Control of Th17 Cell Generation and CNS Inflammation. J Neurol Neurophysiol. 2014;Suppl 12. doi: 10.4172/2155-9562.S12-004. PubMed PMID: 25705564; PubMed Central PMCID: PMC4334382.

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Yang K, Shrestha S, Zeng H, Karmaus PW, Neale G, Vogel P, Guertin DA, Lamb RF, Chi H. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity. 2013 Dec 12;39(6):1043-56. doi: 10.1016/j.immuni.2013.09.015. Epub 2013 Dec 5. PubMed PMID: 24315998; PubMed Central PMCID: PMC3986063.

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Wang Y, Huang G, Zeng H, Yang K, Lamb RF, Chi H. Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4894-903. doi: 10.1073/pnas.1308905110. Epub 2013 Nov 26. PubMed PMID: 24282297; PubMed Central PMCID: PMC3864282.

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Yang K, Chi H. Tuning mTOR activity for immune balance. J Clin Invest. 2013 Dec;123(12):5001-4. doi: 10.1172/JCI73202. Epub 2013 Nov 25. PubMed PMID: 24270416; PubMed Central PMCID: PMC3859402.

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Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature. 2013 Jul 25;499(7459):485-90. doi: 10.1038/nature12297. Epub 2013 Jun 30. PubMed PMID: 23812589; PubMed Central PMCID: PMC3759242.

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Yang K, Chi H. mTOR and metabolic pathways in T cell quiescence and functional activation. Semin Immunol. 2012 Dec;24(6):421-8. doi: 10.1016/j.smim.2012.12.004. Epub 2013 Feb 1. Review. PubMed PMID: 23375549; PubMed Central PMCID: PMC3855395.

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Yang K, Neale G, Green DR, He W, Chi H. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol. 2011 Jul 17;12(9):888-97. doi: 10.1038/ni.2068. PubMed PMID: 21765414; PubMed Central PMCID: PMC3158818.

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Liu G, Yang K, Burns S, Shrestha S, Chi H. The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. Nat Immunol. 2010 Nov;11(11):1047-56. doi: 10.1038/ni.1939. Epub 2010 Sep 19. PubMed PMID: 20852647; PubMed Central PMCID: PMC2958252.

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Shi HX, Yang K, Liu X, Liu XY, Wei B, Shan YF, Zhu LH, Wang C. Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification. Mol Cell Biol. 2010 May;30(10):2424-36. doi: 10.1128/MCB.01466-09. Epub 2010 Mar 22. PubMed PMID: 20308324; PubMed Central PMCID: PMC2863703.

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Zhang B, Li M, Chen L, Yang K, Shan Y, Zhu L, Sun S, Li L, Wang C. The TAK1-JNK cascade is required for IRF3 function in the innate immune response. Cell Res. 2009 Apr;19(4):412-28. doi: 10.1038/cr.2009.8. PubMed PMID: 19153595.

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Yang K, Shi HX, Liu XY, Shan YF, Wei B, Chen S, Wang C. TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response. J Immunol. 2009 Mar 15;182(6):3782-92. doi: 10.4049/jimmunol.0803126. PubMed PMID: 19265157.

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Sun S, Tang Y, Lou X, Zhu L, Yang K, Zhang B, Shi H, Wang C. UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome. J Cell Biol. 2007 Jul 16;178(2):231-44. doi: 10.1083/jcb.200611081. Epub 2007 Jul 9. PubMed PMID: 17620405; PubMed Central PMCID: PMC2064443.

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Qi R, Gu J, Zhang Z, Yang K, Li B, Fan J, Wang C, He Z, Qiao L, Lin Z, Liu XY. Potent antitumor efficacy of XAF1 delivered by conditionally replicative adenovirus vector via caspase-independent apoptosis. Cancer Gene Ther. 2007 Jan;14(1):82-90. doi: 10.1038/sj.cgt.7700992. Epub 2006 Sep 29. PubMed PMID: 17008933.

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Yang K, Shi H, Qi R, Sun S, Tang Y, Zhang B, Wang C. Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. Mol Biol Cell. 2006 Mar;17(3):1461-71. doi: 10.1091/mbc.e05-09-0853. Epub 2006 Jan 4. PubMed PMID: 16394098; PubMed Central PMCID: PMC1382332.

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Diao L, Zhang B, Xuan C, Sun S, Yang K, Tang Y, Qiao W, Chen Q, Geng Y, Wang C. Activation of c-Jun N-terminal kinase (JNK) pathway by HSV-1 immediate early protein ICP0. Exp Cell Res. 2005 Aug 1;308(1):196-210. doi: 10.1016/j.yexcr.2005.04.016. PubMed PMID: 15896775; PubMed Central PMCID: PMC7094335.

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Diao L, Zhang B, Fan J, Gao X, Sun S, Yang K, Xin D, Jin N, Geng Y, Wang C. Herpes virus proteins ICP0 and BICP0 can activate NF-kappaB by catalyzing IkappaBalpha ubiquitination. Cell Signal. 2005 Feb;17(2):217-29. doi: 10.1016/j.cellsig.2004.07.003. PubMed PMID: 15494213.

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Yang K, Zhu J, Sun S, Tang Y, Zhang B, Diao L, Wang C. The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination. Biochem Biophys Res Commun. 2004 Nov 5;324(1):432-9. doi: 10.1016/j.bbrc.2004.09.070. PubMed PMID: 15465037.