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    GSTCD glutathione S-transferase C-terminal domain containing [ Homo sapiens (human) ]

    Gene ID: 79807, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GSTCDprovided by HGNC
    Official Full Name
    glutathione S-transferase C-terminal domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:25806
    See related
    Ensembl:ENSG00000138780 MIM:615912; AllianceGenome:HGNC:25806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.2) and 25 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    4q24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (105708784..105847725)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (109019919..109158852)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (106629941..106768882)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900748 Neighboring gene uncharacterized LOC124900747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21784 Neighboring gene integrator complex subunit 12 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:106703288-106703493 Neighboring gene uncharacterized LOC107986190 Neighboring gene GSTCD antisense RNA 1 Neighboring gene uncharacterized LOC124900749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15611 Neighboring gene Sharpr-MPRA regulatory region 231 Neighboring gene nephronectin Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:106919539-106920322 Neighboring gene uncharacterized LOC101929577

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Defining a role for lung function associated gene GSTCD in cell homeostasis. Henry AP, et al. Respir Res, 2019 Aug 1. PMID 31370853, Free PMC Article
    2. Interaction effects of long-term air pollution exposure and variants in the GSTP1, GSTT1 and GSTCD genes on risk of acute myocardial infarction and hypertension: a case-control study. Levinsson A, et al. PLoS One, 2014. PMID 24915237, Free PMC Article
    3. GSTCD and INTS12 regulation and expression in the human lung. Obeidat M, et al. PLoS One, 2013. PMID 24058608, Free PMC Article
    4. Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Soler Artigas M, et al. Am J Respir Crit Care Med, 2011 Oct 1. PMID 21965014, Free PMC Article
    5. Genome-wide association study identifies five loci associated with lung function. Repapi E, et al. Nat Genet, 2010 Jan. PMID 20010834, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeted knock-down of GSTCD in bronchial epithelial cells identified a role for GSTCD in cell viability.
      Title: Defining a role for lung function associated gene GSTCD in cell homeostasis.
    2. Air pollution exposure entails an increased risk of acute myocardial infarction, and this risk differed over genotype strata for variants in the GSTP1, GSTT1 and GSTCD genes, albeit not statistically-significantly.
      Title: Interaction effects of long-term air pollution exposure and variants in the GSTP1, GSTT1 and GSTCD genes on risk of acute myocardial infarction and hypertension: a case-control study.
    3. In fixed sections of human lung tissue, GSTCD protein expression was ubiquitous, whereas INTS12 expression was predominantly in epithelial cells and pneumocytes.
      Title: GSTCD and INTS12 regulation and expression in the human lung.
    4. GSTCD polymorphism associated with COPD risk and lung function decline
      Title: Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
    6. Data show expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in lung tissue and indicate potential targets for interventions to alleviate respiratory disease.
      Title: Genome-wide association study identifies five loci associated with lung function.
    7. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Gene network analysis in a pediatric cohort identifies novel lung function genes.
    EBI GWAS Catalog
    Genome-wide association study identifies five loci associated with lung function.
    EBI GWAS Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog
    Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13273, DKFZp686I10174

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase C-terminal domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031720.3 → NP_001026890.2  glutathione S-transferase C-terminal domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001026890.2

      Status: VALIDATED

      Source sequence(s)
      AC008243, AK292355, BC032942
      Consensus CDS
      CCDS43257.1
      UniProtKB/Swiss-Prot
      A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3
      Related
      ENSP00000353695.5, ENST00000360505.9
      Conserved Domains (2) summary
      cl02776
      Location:270 → 329
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:423 → 541
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001370181.1 → NP_001357110.1  glutathione S-transferase C-terminal domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008243, AC105391
      Consensus CDS
      CCDS43257.1
      UniProtKB/Swiss-Prot
      A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3
      Related
      ENSP00000422354.1, ENST00000515279.6
      Conserved Domains (2) summary
      cl02776
      Location:270 → 329
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:423 → 541
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_024751.3 → NP_079027.2  glutathione S-transferase C-terminal domain-containing protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008243, AK303547, BC032942, BX648355
      Consensus CDS
      CCDS3672.2
      UniProtKB/Swiss-Prot
      Q8NEC7
      UniProtKB/TrEMBL
      B7Z8J7
      Related
      ENSP00000378218.3, ENST00000394730.7
      Conserved Domains (2) summary
      cl02776
      Location:186 → 242
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:336 → 454
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      105708784..105847725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532252.4 → XP_011530554.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_011530554.1

      UniProtKB/Swiss-Prot
      A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3
      Conserved Domains (2) summary
      cl02776
      Location:270 → 329
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:423 → 541
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_047416179.1 → XP_047272135.1  glutathione S-transferase C-terminal domain-containing protein isoform X2

    3. XM_011532248.4 → XP_011530550.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_011530550.1

      UniProtKB/Swiss-Prot
      A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3
      Conserved Domains (2) summary
      cl02776
      Location:270 → 329
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:423 → 541
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_011532249.4 → XP_011530551.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_011530551.1

      UniProtKB/Swiss-Prot
      A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3
      Conserved Domains (2) summary
      cl02776
      Location:270 → 329
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
      cl17173
      Location:423 → 541
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_938771.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      109019919..109158852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350844.1 → XP_054206819.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3

    2. XM_054350845.1 → XP_054206820.1  glutathione S-transferase C-terminal domain-containing protein isoform X2

    3. XM_054350842.1 → XP_054206817.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3

    4. XM_054350843.1 → XP_054206818.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3

    RNA

    1. XR_008487031.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NEC7.2 GenPept UniProtKB/Swiss-Prot:Q8NEC7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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