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    LOC126860024 BRD4-independent group 4 enhancer GRCh37_chr7:47332661-47333860 [ Homo sapiens (human) ]

    Gene ID: 126860024, updated on 10-Oct-2023

    Summary

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    Gene symbol
    LOC126860024
    Gene description
    BRD4-independent group 4 enhancer GRCh37_chr7:47332661-47333860
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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    Genomic context

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    Location:
    chromosome: 7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (47293063..47294262)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (47454362..47455561)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375268 Neighboring gene MPRA-validated peak6510 silencer Neighboring gene serine and arginine rich splicing factor 8C, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:47162015-47162514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25975 Neighboring gene MPRA-validated peak6511 silencer Neighboring gene uncharacterized LOC124901628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47354649-47355451 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47366159-47366764 Neighboring gene tensin 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:47383941-47384441 Neighboring gene uncharacterized LOC124901629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47410550-47411140 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:47411141-47411732 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:47411733-47412323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47419203-47420066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47440071-47440980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47442727-47443235 Neighboring gene NANOG hESC enhancer GRCh37_chr7:47459035-47459536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47486948-47487448 Neighboring gene small nucleolar RNA, C/D box 151

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_084525.1 

      Range
      101..1300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      47293063..47294262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      47454362..47455561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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