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    NR4A1AS NR4A1 antisense RNA [ Homo sapiens (human) ]

    Gene ID: 115409980, updated on 10-Oct-2023

    Summary

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    Official Symbol
    NR4A1ASprovided by HGNC
    Official Full Name
    NR4A1 antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:54409
    See related
    Ensembl:ENSG00000259884 AllianceGenome:HGNC:54409
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    lncMMPA; NR4A1-AS1
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    Genomic context

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    Location:
    12q13.13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52058750..52059500, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52022329..52023079, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52452534..52453284, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4479 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52418471-52419408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52419409-52420346 Neighboring gene nuclear receptor subfamily 4 group A member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4481 Neighboring gene uncharacterized LOC107984510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52445362-52445919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6389 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:52463395-52464110 Neighboring gene autophagy related 101 Neighboring gene small integral membrane protein 41 Neighboring gene uncharacterized LOC112268096 Neighboring gene olfactory receptor family 7 subfamily E member 47 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LncRNA RP11-1100L3.8 Involves in the Pathogenesis of Multiple Myeloma by Regulating NR4A1. Feng Y, et al. Discov Med, 2023 Feb 1. PMID 37024444
    2. Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway. Xu M, et al. J Exp Clin Cancer Res, 2022 Aug 19. PMID 35986343, Free PMC Article
    3. A novel lncRNA NR4A1AS up-regulates orphan nuclear receptor NR4A1 expression by blocking UPF1-mediated mRNA destabilization in colorectal cancer. Xie X, et al. Clin Sci (Lond), 2019 Jul 15. PMID 31253658

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA RP11-1100L3.8 Involves in the Pathogenesis of Multiple Myeloma by Regulating NR4A1.
      Title: LncRNA RP11-1100L3.8 Involves in the Pathogenesis of Multiple Myeloma by Regulating NR4A1.
    2. NR4A1AS up-regulates NR4A1 expression by forming RNA-RNA complexes and blocking UPF1-mediated mRNA destabilization, promoting tuumor growth and metastasis in colorectal cancer cells.
      Title: A novel lncRNA NR4A1AS up-regulates orphan nuclear receptor NR4A1 expression by blocking UPF1-mediated mRNA destabilization in colorectal cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    General gene information

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    Other Names

    • M2 macrophage polarization associated lncRNA
    • RP11-1100L3.8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_170321.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC025259
      Related
      ENST00000564363.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      52058750..52059500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      52022329..52023079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases