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    PB2 polymerase PB2 [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

    Gene ID: 956536, updated on 29-Nov-2023

    Summary

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    Gene symbol
    PB2
    Gene description
    polymerase PB2
    Locus tag
    FLUAVs1gp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1)
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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    Genomic context

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    Location:
    segment: 1
    Sequence:
    NC_002023.1 (28..2307)

    NC_002023.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002023.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Virtual Screening and Molecular Dynamics Simulation Study of Influenza Polymerase PB2 Inhibitors. Zong K, et al. Molecules, 2021 Nov 17. PMID 34834044, Free PMC Article
    2. Crystallization and X-ray diffraction analysis of the RNA primer/promoter-binding domain of influenza A virus RNA-dependent RNA polymerase PB2. Kuzuhara T, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Feb 1. PMID 19194006, Free PMC Article
    3. Adaptive strategies of the influenza virus polymerase for replication in humans. Mehle A, et al. Proc Natl Acad Sci U S A, 2009 Dec 15. PMID 19995968, Free PMC Article
    4. Biological and structural characterization of a host-adapting amino acid in influenza virus. Yamada S, et al. PLoS Pathog, 2010 Aug 5. PMID 20700447, Free PMC Article
    5. Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase. Foeglein Á, et al. J Gen Virol, 2011 Jul. PMID 21471313, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein arginine methyltransferase 5 mediates arginine symmetric dimethylation of influenza A virus PB2 and supports viral replication.
      Title: Protein arginine methyltransferase 5 mediates arginine symmetric dimethylation of influenza A virus PB2 and supports viral replication.
    2. Virtual Screening and Molecular Dynamics Simulation Study of Influenza Polymerase PB2 Inhibitors.
      Title: Virtual Screening and Molecular Dynamics Simulation Study of Influenza Polymerase PB2 Inhibitors.
    3. Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir.
      Title: Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir.
    4. A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.
      Title: A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.
    5. Nonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases.
      Title: Nonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases.
    6. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
      Title: TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
    7. The study confirmed the polygenic nature of Influenza A virus virulence, with several sites in PB2 playing more dominant role (meta-analysis).
      Title: Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice.
    8. The C-terminal portion of ANP32A and the middle domains (residues 307-534) of PB2 were required for PB2-ANP32A interaction.
      Title: The interaction of cellular protein ANP32A with influenza A virus polymerase component PB2 promotes vRNA synthesis.
    9. Viral polymerase activity, viral replication, and pathogenicity in mice were enhanced due to the substitution of D701N in the PB2 protein.
      Title: Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses.
    10. Two miRNAs, miR-584-5p and miR-1249, that matched with the PB2 binding sequence, dramatically down-regulated PB2 expression, and inhibited replication of H5N1 and H1N1 influenza A virus strains in A549 cells.
      Title: The highly pathogenic H5N1 influenza A virus down-regulated several cellular MicroRNAs which target viral genome.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    polymerase PB2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002023.1 Reference assembly

      Range
      28..2307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040987.1 polymerase PB2 [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

      See identical proteins and their annotated locations for NP_040987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2R4QPN2, D3J174, F5CGP0, M9V1B6
      Conserved Domains (1) summary
      pfam00604
      Location:1 → 757
      Flu_PB2; Influenza RNA-dependent RNA polymerase subunit PB2
    Nucleotide Protein
    Heading Accession and Version

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