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    PA polymerase PA [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

    Gene ID: 956535, updated on 18-Aug-2023

    Summary

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    Gene symbol
    PA
    Gene description
    polymerase PA
    Locus tag
    FLUAVs3gp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1)
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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    Genomic context

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    Location:
    segment: 3
    Sequence:
    NC_002022.1 (25..2175)

    NC_002022.1Genomic Context describing neighboring genes Neighboring gene PA-X protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002022.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism. Kumar G, et al. Nucleic Acids Res, 2021 Feb 22. PMID 33469660, Free PMC Article
    2. Priming and realignment by the influenza a virus RdRp is dependent on the length of the host primers and the extent of base pairing to viral RNA. De Vlugt C, et al. Virology, 2019 Oct. PMID 31404845
    3. A novel function of the N-terminal domain of PA in assembly of influenza A virus RNA polymerase. Suzuki T, et al. Biochem Biophys Res Commun, 2011 Nov 4. PMID 22001919
    4. Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast. Oishi K, et al. Virology, 2018 Mar. PMID 29331676, Free PMC Article
    5. Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain. Bhoye D, et al. Arch Virol, 2018 Apr. PMID 29273880

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1.
      Title: Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1.
    2. Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
      Title: Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
    3. Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism.
      Title: Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism.
    4. Priming and realignment by the influenza a virus RNA-Dependent RNA Polymerase is dependent on the length of the host primers and the extent of base pairing to viral RNA.
      Title: Priming and realignment by the influenza a virus RdRp is dependent on the length of the host primers and the extent of base pairing to viral RNA.
    5. substitutions in HA (Asp225Gly or Gln226Arg) and compensatory mutation decreasing the charge of HA (Lys123Asn, Lys157Asn, Gly158Glu, Asn159Asp, or Lys212Met) altered viral receptor-binding specificity and restored the functional balance between HA and NA; (2) Phe35Leu substitution in the PA protein increased viral polymerase activity.
      Title: [Mutations in Hemagglutinin and Polymerase Alter the Virulence of Pandemic A(H1N1) Influenza Virus].
    6. A recombinant pandemic H1N1 virus containing PA, PA-X, and NS1 genes from currently circulating viruses is fitter in replication in cultured cells and in mice and is slightly more pathogenic than the original ancestor pandemic H1N1 virus.
      Title: Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans.
    7. The 22 amino acids of the N-terminal of PA are important for the shutoff activity.
      Title: Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast.
    8. Computational analysis of the effect of polymerase acidic gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain has been presented.
      Title: Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain.
    9. The human (H1N1) and avian (H7N9) strain PA-C-terminal domain proteins exhibit the same global topology as other strains in the absence of PB1, but differ extensively in the PB1 binding pocket.
      Title: Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1.
    10. The ts-mutations in PB1, PB2, and PA genes are mostly involved in the modulation of the humoral immunity, but also have a moderate effect on the cellular adaptive immune response.
      Title: [Effect of Point Mutations in the Polymerase Genes of the Influenza A/PR/8/34 (H1N1) Virus on the Immune Response in a Mouse Model].
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    polymerase PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002022.1 Reference assembly

      Range
      25..2175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040986.1 polymerase PA [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

      See identical proteins and their annotated locations for NP_040986.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4GXH3, P03433, Q20N31, Q8JUU6
      UniProtKB/TrEMBL
      A0A1D8EMV6, A0A1U9W4S2, A0A5J6BSB7, B4UPB3, C3PQG3, C7S1X8, C7S277, F0TTJ6, F0TTS3, F0TU44, F0TU66, I6S596, I6S6F2, I6S731, I6SHZ7, I6SIR4, I6T2F0, I6T4X9, I6TBS4, I6THD6, J7GS12, R9WMJ0, S5FTI8, S5G005
      Conserved Domains (1) summary
      pfam00603
      Location:21 → 715
      Flu_PA; Influenza RNA-dependent RNA polymerase subunit PA
    Nucleotide Protein
    Heading Accession and Version

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