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    nanM N-acetylneuraminate mutarotase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949106, updated on 10-Oct-2024

    Summary

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    Official Symbol
    nanM
    Official Full Name
    N-acetylneuraminate mutarotase
    Primary source
    ECOCYC:G7920
    Locus tag
    b4310
    See related
    ASAP:ABE-0014132
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4301; yjhT
    Summary
    NanM has N-acetylneuraminic acid mutarotase activity and is required for the efficient utilization of N-acetylneuraminic acid (Da Severi, 2008). [More information is available at EcoGene: EG12562]. N-acetylneuraminate mutarotase supports the efficient use of -N-acetylneuraminate (-Neu5Ac) as the sole source of carbon. [More information is available at EcoCyc: G7920].
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    Genomic context

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    Sequence:
    NC_000913.3 (4537659..4538765, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene protein YthB Neighboring gene N-acetyl-9-O-acetylneuraminate esterase Neighboring gene N-acetylneuraminate outer membrane channel Neighboring gene Type 1 fimbriae regulatory protein FimB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function and expression of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. Condemine G, et al. J Bacteriol, 2005 Mar. PMID 15743943, Free PMC Article
    2. Fishing new proteins in the twilight zone of genomes: the test case of outer membrane proteins in Escherichia coli K12, Escherichia coli O157:H7, and other Gram-negative bacteria. Casadio R, et al. Protein Sci, 2003 Jun. PMID 12761386, Free PMC Article
    3. Identification and functional analysis of 'hypothetical' genes expressed in Haemophilus influenzae. Kolker E, et al. Nucleic Acids Res, 2004. PMID 15121896, Free PMC Article
    4. Comparison of the large-scale periplasmic proteomes of the Escherichia coli K-12 and B strains. Han MJ, et al. J Biosci Bioeng, 2014 Apr. PMID 24140104
    5. Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT. Severi E, et al. J Biol Chem, 2008 Feb 22. PMID 18063573

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylneuraminate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylneuraminate mutarotase
    NP_418730.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4537659..4538765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418730.4 N-acetylneuraminate mutarotase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418730.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EGH8, A0AAN5JDK2
      Conserved Domains (2) summary
      PRK14131
      Location:4 → 368
      PRK14131; N-acetylneuraminate epimerase
      sd00038
      Location:75 → 126
      Kelch; KELCH repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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