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    radA DNA recombination protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948912, updated on 10-Oct-2024

    Summary

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    Official Symbol
    radA
    Official Full Name
    DNA recombination protein
    Primary source
    ECOCYC:EG11296
    Locus tag
    b4389
    See related
    ASAP:ABE-0014395
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4381; sms
    Summary
    RadA is involved in processing of DNA recombination intermediates . [More information is available at EcoCyc: EG11296].
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    Genomic context

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    Sequence:
    NC_000913.3 (4625912..4627294)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative inner membrane protein Smp Neighboring gene phosphoserine phosphatase Neighboring gene DNA-binding transcriptional repressor/NMN adenylyltransferase NadR Neighboring gene energy-dependent translational throttle protein EttA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RadA-mediated branch migration aids recombination by allowing the 3' invading strand to be incorporated into heteroduplex DNA and to be extended by DNA polymerases.
      Title: Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli.
    2. findings show that the putative Zn finger, Walker A motif, KNRXG motif and Lon protease homology domain of the Escherichia coli RadA protein are required for DNA damage survival
      Title: Genetic analysis of Escherichia coli RadA: functional motifs and genetic interactions.
    3. Study shows that enhanced recombination is dependent on the factors: the RuvA Holliday junction helicase, the RecJ single-strand DNA exonuclease, the RadA/Sms RecA-paralog protein of unknown function and, surprisingly, the DinB translesion polymerase.
      Title: Replication arrest-stimulated recombination: Dependence on the RecA paralog, RadA/Sms and translesion polymerase, DinB.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within recombinational repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in recombinational repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within recombinational repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in recombinational repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA recombination protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4625912..4627294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418806.1 DNA recombination protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418806.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3TU22
      Conserved Domains (1) summary
      TIGR00416
      Location:1 → 454
      sms; DNA repair protein RadA
    Nucleotide Protein
    Heading Accession and Version

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