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    dmsA dimethyl sulfoxide reductase subunit A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945508, updated on 19-Sep-2024

    Summary

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    Official Symbol
    dmsA
    Official Full Name
    dimethyl sulfoxide reductase subunit A
    Primary source
    ECOCYC:EG10232
    Locus tag
    b0894
    See related
    ASAP:ABE-0003044
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0885
    Summary
    Verified Tat substrate: [More information is available at EcoGene: EG10232]. This subunit contains the active site and the molybdenum cofactor . [More information is available at EcoCyc: EG10232].
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    Genomic context

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    Sequence:
    NC_000913.3 (940959..943403)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene replication-associated recombination protein A Neighboring gene serine--tRNA ligase Neighboring gene dimethyl sulfoxide reductase subunit B Neighboring gene dimethyl sulfoxide reductase subunit C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple roles for the twin arginine leader sequence of dimethyl sulfoxide reductase of Escherichia coli. Sambasivarao D, et al. J Biol Chem, 2000 Jul 21. PMID 10801884
    2. Molecular cloning and expression of the Escherichia coli dimethyl sulfoxide reductase operon. Bilous PT, et al. J Bacteriol, 1988 Apr. PMID 2832366, Free PMC Article
    3. Alteration of the iron-sulfur cluster composition of Escherichia coli dimethyl sulfoxide reductase by site-directed mutagenesis. Rothery RA, et al. Biochemistry, 1991 Aug 27. PMID 1653010
    4. Identification of a twin-arginine leader-binding protein. Oresnik IJ, et al. Mol Microbiol, 2001 Apr. PMID 11309116
    5. Multiple pathways of electron transfer in dimethyl sulfoxide reductase of Escherichia coli. Trieber CA, et al. J Biol Chem, 1994 Mar 11. PMID 8125918

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that a portion of the hydrophobic region of the DmsA leader peptide determines the specificity of binding and may produce helical properties upon binding to chaperone protein DmsD (twin-arginine leader-binding protein).
      Title: The hydrophobic region of the DmsA twin-arginine leader peptide determines specificity with chaperone DmsD.
    2. established an additional role for the cluster in directing molybdenum cofactor assembly during enzyme maturation
      Title: Correct assembly of iron-sulfur cluster FS0 into Escherichia coli dimethyl sulfoxide reductase (DmsABC) is a prerequisite for molybdenum cofactor insertion.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Nucleotide sequence of the dmsABC operon encoding the anaerobic dimethylsulphoxide reductase of Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dimethyl sulfoxide reductase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables dimethyl sulfoxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin cofactor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within anaerobic respiration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in dimethyl sulfoxide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of dimethyl sulfoxide reductase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of dimethyl sulfoxide reductase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dimethyl sulfoxide reductase subunit A
    NP_415414.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      940959..943403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415414.4 dimethyl sulfoxide reductase subunit A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415414.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WS45
      Conserved Domains (1) summary
      PRK14990
      Location:1 → 814
      PRK14990; anaerobic dimethyl sulfoxide reductase subunit A; Provisional
    Nucleotide Protein
    Heading Accession and Version

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