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    MOB1B MOB kinase activator 1B [ Homo sapiens (human) ]

    Gene ID: 92597, updated on 3-Nov-2024

    Summary

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    Official Symbol
    MOB1Bprovided by HGNC
    Official Full Name
    MOB kinase activator 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:29801
    See related
    Ensembl:ENSG00000173542 MIM:609282; AllianceGenome:HGNC:29801
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MATS2; MOB4A; MOBKL1A
    Summary
    The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in kidney (RPKM 9.7), bone marrow (RPKM 8.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MOB1B in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70901851..70988168)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (74244289..74330605)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71768086..71853885)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 891, pseudogene Neighboring gene uncharacterized LOC124900711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15473 Neighboring gene Sharpr-MPRA regulatory region 2882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:71869952-71870648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21605 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:71883900-71884096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:71894495-71894995 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:71924658-71925260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:71925261-71925861 Neighboring gene deoxycytidine kinase Neighboring gene solute carrier family 4 member 4 Neighboring gene uncharacterized LOC124900712

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human Mob1 proteins are required for cytokinesis by controlling microtubule stability. Florindo C, et al. J Cell Sci, 2012 Jul 1. PMID 22454515
    2. The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Hergovich A, et al. Biochem Biophys Res Commun, 2006 Jun 23. PMID 16674920
    3. miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer. Pang H, et al. Cancer Sci, 2023 Apr. PMID 36445107, Free PMC Article
    4. Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling. Bae JS, et al. Cell Death Dis, 2018 Oct 22. PMID 30349003, Free PMC Article
    5. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. Bichsel SJ, et al. J Biol Chem, 2004 Aug 20. PMID 15197186

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer.
      Title: miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer.
    2. MOB1A/B has an essential function for intestinal epithelial homeostasis.
      Title: Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.
    3. Mob1A and Mob1B are needed for cell abscission and centriole re-joining after telophase and cytokinesis.
      Title: Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.
    4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33910

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MOB kinase activator 1B
    Names
    MOB1 Mps One Binder homolog B
    MOB1, Mps One Binder kinase activator-like 1A
    mob1 homolog 1A
    mob1A
    mps one binder kinase activator-like 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244766.2 → NP_001231695.1  MOB kinase activator 1B isoform 1

      See identical proteins and their annotated locations for NP_001231695.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC021989, AC093851, AK299481
      Consensus CDS
      CCDS58903.1
      UniProtKB/Swiss-Prot
      Q7L9L4
      Related
      ENSP00000379366.2, ENST00000396051.2
      Conserved Domains (1) summary
      pfam03637
      Location:38 → 209
      Mob1_phocein; Mob1/phocein family

    2. NM_001244767.2 → NP_001231696.1  MOB kinase activator 1B isoform 3

      See identical proteins and their annotated locations for NP_001231696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC108014, AK093545
      UniProtKB/TrEMBL
      B3KSH6, D6RCK3
      Related
      ENST00000509041.5
      Conserved Domains (1) summary
      pfam03637
      Location:33 → 139
      Mob1_phocein; Mob1/phocein family

    3. NM_173468.4 → NP_775739.1  MOB kinase activator 1B isoform 2

      See identical proteins and their annotated locations for NP_775739.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC021989, AC093851, BC038112
      Consensus CDS
      CCDS34002.1
      UniProtKB/Swiss-Prot
      B2R8U6, B4DRY3, Q7L9L4, Q8IY23
      Related
      ENSP00000310189.3, ENST00000309395.7
      Conserved Domains (1) summary
      pfam03637
      Location:33 → 204
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      70901851..70988168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532412.3 → XP_011530714.1  MOB kinase activator 1B isoform X2

      Conserved Domains (1) summary
      pfam03637
      Location:57 → 228
      Mob1_phocein; Mob1/phocein family

    2. XM_005265709.3 → XP_005265766.1  MOB kinase activator 1B isoform X3

      See identical proteins and their annotated locations for XP_005265766.1

      UniProtKB/Swiss-Prot
      Q7L9L4
      Conserved Domains (1) summary
      pfam03637
      Location:38 → 209
      Mob1_phocein; Mob1/phocein family

    3. XM_017008837.2 → XP_016864326.1  MOB kinase activator 1B isoform X1

      Conserved Domains (1) summary
      pfam03637
      Location:64 → 235
      Mob1_phocein; Mob1/phocein family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      74244289..74330605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351248.1 → XP_054207223.1  MOB kinase activator 1B isoform X2

    2. XM_054351249.1 → XP_054207224.1  MOB kinase activator 1B isoform X3

    3. XM_054351247.1 → XP_054207222.1  MOB kinase activator 1B isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L9L4.3 GenPept UniProtKB/Swiss-Prot:Q7L9L4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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