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    ZNF622 zinc finger protein 622 [ Homo sapiens (human) ]

    Gene ID: 90441, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF622provided by HGNC
    Official Full Name
    zinc finger protein 622provided by HGNC
    Primary source
    HGNC:HGNC:30958
    See related
    Ensembl:ENSG00000173545 MIM:608694; AllianceGenome:HGNC:30958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZPR9
    Summary
    Enables preribosome binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Located in Golgi apparatus; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart (RPKM 14.7), colon (RPKM 14.5) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See ZNF622 in Genome Data Viewer
    Location:
    5p15.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (16451519..16465800, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (16390866..16405145, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (16451628..16465909, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NACA pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16335723-16336270 Neighboring gene long intergenic non-protein coding RNA 2150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16436325-16436842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22421 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16467094-16467316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22423 Neighboring gene reticulophagy regulator 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16535515-16536016 Neighboring gene Sharpr-MPRA regulatory region 7449 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:16575232-16575796 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16606665-16606881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15947 Neighboring gene RETREG1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16711171-16711672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16718131-16718712 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:16721745-16722434 Neighboring gene myosin X Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:16741036-16741940 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16741941-16742846 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:16754668-16755308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16755309-16755949 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16794335-16794862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16794863-16795390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16805998-16806498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16806499-16806999 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:16809483-16809982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16829693-16830613 Neighboring gene RNA, 5S ribosomal pseudogene 179

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). Seong HA, et al. Biochem J, 2002 Feb 1. PMID 11802789, Free PMC Article
    2. Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. Seong HA, et al. J Biol Chem, 2003 Mar 14. PMID 12645566
    3. Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein. Seong HA, et al. J Biol Chem, 2011 Sep 9. PMID 21771788, Free PMC Article
    4. Thioredoxin inhibits MPK38-induced ASK1, TGF-β, and p53 function in a phosphorylation-dependent manner. Manoharan R, et al. Free Radic Biol Med, 2013 Oct. PMID 23747528
    5. Guanine Nucleotide-Binding Protein-Like 1 (GNL1) binds RNA G-quadruplex structures in genes associated with Parkinson's disease. Turcotte MA, et al. RNA Biol, 2021 Sep. PMID 33305682, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that ZNF622 is a putative expression variability marker for the 3-day, 8-cell embryo stage.
      Title: Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
    2. ZPR9 was found to physically interact with ASK1 through a disulfide linkage;ZPR9 functions as a novel positive regulator of ASK1.
      Title: Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein.
    3. ZPR9 plays an important role in modulation of the transactivation by B-MYB and cellular growth of neuroblastoma cells
      Title: Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2485, MGC17552

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables preribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic 60S subunit biogenesis factor ZNF622
    Names
    zinc finger-like protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033414.3 → NP_219482.1  cytoplasmic 60S subunit biogenesis factor ZNF622

      See identical proteins and their annotated locations for NP_219482.1

      Status: VALIDATED

      Source sequence(s)
      AC020980, BC008752
      Consensus CDS
      CCDS3886.1
      UniProtKB/Swiss-Prot
      Q969S3
      Related
      ENSP00000310042.2, ENST00000308683.3
      Conserved Domains (4) summary
      PTZ00448
      Location:6 → 49
      PTZ00448; hypothetical protein; Provisional
      sd00020
      Location:6 → 28
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:68 → 91
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam12756
      Location:254 → 353
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      16451519..16465800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      16390866..16405145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q969S3.1 GenPept UniProtKB/Swiss-Prot:Q969S3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools