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    secA1 protein translocase subunit SecA [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888860, updated on 6-Jun-2024

    Summary

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    Gene symbol
    secA1
    Gene description
    protein translocase subunit SecA
    Locus tag
    Rv3240c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    secA
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    Genomic context

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    Sequence:
    NC_000962.3 (3617682..3620531, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene integral membrane protein Neighboring gene transmembrane transport protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2. Swanson S, et al. J Bacteriol, 2015 Dec 14. PMID 26668263, Free PMC Article
    2. In Vitro Interaction of the Housekeeping SecA1 with the Accessory SecA2 Protein of Mycobacterium tuberculosis. Prabudiansyah I, et al. PLoS One, 2015. PMID 26047312, Free PMC Article
    3. ADP-dependent conformational changes distinguish Mycobacterium tuberculosis SecA2 from SecA1. D'Lima NG, et al. J Biol Chem, 2014 Jan 24. PMID 24297168, Free PMC Article
    4. ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance for SecA2 function in macrophages. Hou JM, et al. J Bacteriol, 2008 Jul. PMID 18487341, Free PMC Article
    5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Many of the structural features of SecA1 are conserved in the SecA2 structure, including putative contacts with the SecYEG channel.
      Title: Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.
    2. The housekeeping protein SecA1 forms heterodimers with the accessory SecA2 protein of Mycobacterium tuberculosis in solution.
      Title: In Vitro Interaction of the Housekeeping SecA1 with the Accessory SecA2 Protein of Mycobacterium tuberculosis.
    3. conformational change involving closure of the clamp in SecA2 may provide a mechanism for the cell to direct protein export through the conventional SecA1 pathway under normal growth conditions
      Title: ADP-dependent conformational changes distinguish Mycobacterium tuberculosis SecA2 from SecA1.
    4. Here, M. tuberculosis SecA1 and SecA2 are shown to bind ATP with high affinity
      Title: ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance for SecA2 function in macrophages.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    protein translocase subunit SecA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      3617682..3620531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_177950.1 protein translocase subunit SecA [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for YP_177950.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0T9KKZ8
      Conserved Domains (1) summary
      PRK12904
      Location:1 → 833
      PRK12904; preprotein translocase subunit SecA; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WGP5.1

    Gene LinkOut

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