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    RPL8A ribosomal 60S subunit protein L8A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856352, updated on 3-Nov-2024

    Summary

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    Official Symbol
    RPL8A
    Official Full Name
    ribosomal 60S subunit protein L8A
    Primary source
    SGD:S000001025
    Locus tag
    YHL033C
    See related
    AllianceGenome:SGD:S000001025; FungiDB:YHL033C; VEuPathDB:YHL033C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MAK7
    Summary
    Predicted to enable RNA binding activity. Involved in maturation of LSU-rRNA. Part of cytosolic large ribosomal subunit. Orthologous to human RPL7A (ribosomal protein L7a). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RPL8A in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (35255..36025, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene putative ATP-binding cassette multidrug transporter VMR1 Neighboring gene Sbp1p Neighboring gene glycerol kinase Neighboring gene Gos1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Twenty-six chromosomal genes needed to maintain the killer double-stranded RNA plasmid of Saccharomyces cerevisiae. Wickner RB. Genetics, 1978 Mar. PMID 346439, Free PMC Article
    2. Ribosomal protein L4 of Saccharomyces cerevisiae: the gene and its protein. Arevalo SG, et al. Nucleic Acids Res, 1990 Mar 25. PMID 2183194, Free PMC Article
    3. The organization and expression of the Saccharomyces cerevisiae L4 ribosomal protein genes and their identification as the homologues of the mammalian ribosomal protein gene L7a. Yon J, et al. Mol Gen Genet, 1991 May. PMID 2046660
    4. Ski6p is a homolog of RNA-processing enzymes that affects translation of non-poly(A) mRNAs and 60S ribosomal subunit biogenesis. Benard L, et al. Mol Cell Biol, 1998 May. PMID 9566888, Free PMC Article
    5. Mapping the functional domains of yeast NMD3, the nuclear export adapter for the 60 S ribosomal subunit. Hedges J, et al. J Biol Chem, 2006 Dec 1. PMID 17015443

    See all (175) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. L7 and L8 might establish RNP structures within assembling ribosomes necessary for the stable association and function of the A(3) assembly factors and for proper assembly of the neighborhoods containing domains I and II.
      Title: Ribosomal proteins L7 and L8 function in concert with six A₃ assembly factors to propagate assembly of domains I and II of 25S rRNA in yeast 60S ribosomal subunits.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L8A
    NP_011830.1
    • Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8A has paralog RPL8B from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      35255..36025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179113.1 → NP_011830.1  TPA: ribosomal 60S subunit protein L8A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011830.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKT5, P17076
      UniProtKB/TrEMBL
      A6ZSL7, B3LS86, B5VJP5, C8ZA30, N1P4I2
      Conserved Domains (1) summary
      PTZ00365
      Location:2 → 251
      PTZ00365; 60S ribosomal protein L7Ae-like; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17076.4

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