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    FUM1 fumarase FUM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855866, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FUM1
    Official Full Name
    fumarase FUM1
    Primary source
    SGD:S000006183
    Locus tag
    YPL262W
    See related
    AllianceGenome:SGD:S000006183; FungiDB:YPL262W; VEuPathDB:YPL262W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables fumarate hydratase activity. Involved in fumarate metabolic process and tricarboxylic acid cycle. Located in cytosol and mitochondrial matrix. Is active in nucleus. Used to study leiomyomatosis. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FUM1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (47336..48802)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Kel3p Neighboring gene uncharacterized protein Neighboring gene Cub1p Neighboring gene Apm1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fumaric acid overproduction in yeast mutants deficient in fumarase. Kaclíková E, et al. FEMS Microbiol Lett, 1992 Mar 1. PMID 1587456
    2. Mitochondrial and cytosolic isoforms of yeast fumarase are derivatives of a single translation product and have identical amino termini. Sass E, et al. J Biol Chem, 2001 Dec 7. PMID 11585823
    3. Bacterial fumarase and L-malic acid are evolutionary ancient components of the DNA damage response. Singer E, et al. Elife, 2017 Nov 15. PMID 29140245, Free PMC Article
    4. Import into mitochondria, folding and retrograde movement of fumarase in yeast. Knox C, et al. J Biol Chem, 1998 Oct 2. PMID 9748223
    5. Translation-coupled translocation of yeast fumarase into mitochondria in vivo. Yogev O, et al. J Biol Chem, 2007 Oct 5. PMID 17666392

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Post-translational Modifications of Fumarase Regulate its Enzyme Activity and Function in Respiration and the DNA Damage Response.
      Title: Post-translational Modifications of Fumarase Regulate its Enzyme Activity and Function in Respiration and the DNA Damage Response.
    2. Data suggest that fumarase and fumaric acid are critical elements of the DNA damage response, which underlies the tumor suppressor role of fumarase in human cells and which is most probably HIF independent.
      Title: Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response.
    3. Dual distribution of fumarase in mitochondria and cytosol depends on an enzymatically active Cit2.
      Title: Dual localization of fumarase is dependent on the integrity of the glyoxylate shunt.
    4. cytosolic exposure of the fumarase nascent chain depends on both translocation and translation rates
      Title: Translation-coupled translocation of yeast fumarase into mitochondria in vivo.
    5. extramitochondrial presence of yeast fumarase is mainly caused by the poor mitochondrial targeting characteristics of its mitochondrial targeting sequence
      Title: Mitochondrial import of human and yeast fumarase in live mammalian cells: retrograde translocation of the yeast enzyme is mainly caused by its poor targeting sequence.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables fumarate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fumarate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fumarate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fumarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fumarate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fumarate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fumarase FUM1
    NP_015061.1
    • Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      47336..48802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184076.1 → NP_015061.1  TPA: fumarase FUM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015061.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3A8, P08417, Q08978
      UniProtKB/TrEMBL
      A6ZVZ4, B3LKH1, C7GSG3, C8ZIB7, G2WNS4, N1NW16
      Conserved Domains (1) summary
      PRK00485
      Location:26 → 488
      fumC; fumarate hydratase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08417.2

    Gene LinkOut

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