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    MET18 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854678, updated on 11-Sep-2024

    Summary

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    Official Symbol
    MET18
    Primary source
    SGD:S000001390
    Locus tag
    YIL128W
    See related
    AllianceGenome:SGD:S000001390; FungiDB:YIL128W; VEuPathDB:YIL128W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MMS19
    Summary
    Involved in protein maturation by iron-sulfur cluster transfer. Located in cytoplasm. Part of CIA complex. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (113806..116904)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Asg1p Neighboring gene Tao3p Neighboring gene Rrt14p Neighboring gene RSC chromatin remodeling complex ATPase subunit STH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ. Kiktev DA, et al. Nucleic Acids Res, 2021 Jun 4. PMID 34019669, Free PMC Article
    2. Saccharomyces cerevisiae mms19 mutants are deficient in transcription-coupled and global nucleotide excision repair. Lombaerts M, et al. Nucleic Acids Res, 1997 Oct 15. PMID 9321645, Free PMC Article
    3. Dual requirement for the yeast MMS19 gene in DNA repair and RNA polymerase II transcription. Lauder S, et al. Mol Cell Biol, 1996 Dec. PMID 8943333, Free PMC Article
    4. Three additional genes involved in pyrimidine dimer removal in Saccharomyces cerevisiae: RAD7, RAD14 and MMS19. Prakash L, et al. Mol Gen Genet, 1979 Nov. PMID 392238
    5. Identification of MMS19 domains with distinct functions in NER and transcription. Hatfield MD, et al. DNA Repair (Amst), 2006 Aug 13. PMID 16797255

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MET18 deficiency diminished the replicative capacity of yeast cells as evidenced by the shortened replicative lifespan, which can be restored by CTT1 overexpression, but not by CTA1, in the MET18-deficient cells.
      Title: MET18 Deficiency Increases the Sensitivity of Yeast to Oxidative Stress and Shortens Replicative Lifespan by Inhibiting Catalase Activity.
    2. identified MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery; MMS19 functions as part of the CIA targeting complex that interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance
      Title: MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    part_of cytosolic [4Fe-4S] assembly targeting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic [4Fe-4S] assembly targeting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Met18p
    NP_012138.1
    • Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation and maturation of a subset of cytosolic and nuclear proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      113806..116904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179476.1 → NP_012138.1  TPA: Met18p [Saccharomyces cerevisiae S288C]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVF9, P40469, P89106, Q45U11
      UniProtKB/TrEMBL
      B3LTX5, N1P0T9
      Conserved Domains (2) summary
      pfam12460
      Location:567 → 953
      MMS19_C; RNAPII transcription regulator C-terminal
      pfam14500
      Location:49 → 313
      MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40469.1

    Gene LinkOut

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