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    TPM2 tropomyosin TPM2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854668, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TPM2
    Official Full Name
    tropomyosin TPM2
    Primary source
    SGD:S000001400
    Locus tag
    YIL138C
    See related
    AllianceGenome:SGD:S000001400; FungiDB:YIL138C; VEuPathDB:YIL138C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables actin lateral binding activity. Involved in actin filament bundle assembly; cellular bud site selection; and mitotic actomyosin contractile ring assembly. Located in actin filament bundle and cellular bud neck contractile ring. Is active in actin filament. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TPM2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (89230..89715, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Axl2p Neighboring gene Rev7p Neighboring gene Tma108p Neighboring gene Om45p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray crystallographic analysis of full-length yeast tropomyosin 2 from Saccharomyces cerevisiae. Meshcheryakov V, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Jun 1. PMID 18540067, Free PMC Article
    2. Site-specific amino-terminal mutants of yeast-expressed beta-actin. Characterization of the interaction with myosin and tropomyosin. Aspenström P, et al. FEBS Lett, 1992 May 25. PMID 1534298
    3. Roles of type II myosin and a tropomyosin isoform in retrograde actin flow in budding yeast. Huckaba TM, et al. J Cell Biol, 2006 Dec 18. PMID 17178912, Free PMC Article
    4. Modulation of myosin function by isoform-specific properties of Saccharomyces cerevisiae and muscle tropomyosins. Strand J, et al. J Biol Chem, 2001 Sep 14. PMID 11457840
    5. Regulatory properties of tropomyosin effects of length, isoform, and N-terminal sequence. Maytum R, et al. Biochemistry, 2001 Jun 19. PMID 11401582

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin lateral binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin filament bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tropomyosin TPM2
    NP_012128.3
    • Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      89230..89715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179486.3 → NP_012128.3  TPA: tropomyosin TPM2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012128.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVE8, P40414
      UniProtKB/TrEMBL
      A6ZVD7, B3LTY6, C7GUQ6, C8ZAX5, N1P1V6
      Conserved Domains (1) summary
      pfam12718
      Location:7 → 148
      Tropomyosin_1; Tropomyosin like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40414.1

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