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    MIC10 Mic10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850300, updated on 29-Jun-2024

    Summary

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    Gene symbol
    MIC10
    Gene description
    Mic10p
    Primary source
    FungiDB:YCL057C-A
    Locus tag
    YCL057C-A
    See related
    SGD:S000007547; AllianceGenome:SGD:S000007547; VEuPathDB:YCL057C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MCS10; MIO10; MOS1
    Summary
    Involved in cristae formation. Located in mitochondrial crista junction. Part of MICOS complex. Orthologous to human MICOS10 (mitochondrial contact site and cristae organizing system subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MIC10 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (24032..24325, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene ribosome biosynthesis protein KRR1 Neighboring gene Fyv5p Neighboring gene Adf1p Neighboring gene metalloendopeptidase Neighboring gene Pex34p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mic10 oligomerizes to bend mitochondrial inner membranes at cristae junctions. Barbot M, et al. Cell Metab, 2015 May 5. PMID 25955211
    2. A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria. Callegari S, et al. J Mol Biol, 2019 Jul 12. PMID 31103774
    3. Central role of Mic10 in the mitochondrial contact site and cristae organizing system. Bohnert M, et al. Cell Metab, 2015 May 5. PMID 25955210
    4. Two-dimensional benzyldimethyl-n-hexadecylammonium chloride/SDS-PAGE for membrane proteomics. Zahedi RP, et al. Proteomics, 2005 Sep. PMID 16075424
    5. Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and Cardiolipin. Rampelt H, et al. J Mol Biol, 2018 Jun 22. PMID 29733859

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that Mic10 assembly is controlled by at least two distinct pathways, Mic26-Mic27 antagonism and cardiolipin binding. Simultaneous deficiency of destabilizing Mic26 and stabilizing cardiolipin leads to an intermediate effect on Mic10 oligomers.
      Title: Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and Cardiolipin.
    2. Mic10 interacts with the dimeric form of mitochondrial F1Fo-ATP synthase.
      Title: Mic10, a Core Subunit of the Mitochondrial Contact Site and Cristae Organizing System, Interacts with the Dimeric F(1)F(o)-ATP Synthase.
    3. Data indicate that Fcj1 and Mos1 are required for maintaining mitochondrial DNA (mtDNA) nucleoid size.
      Title: Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology.
    4. Proteomic analyses reveal MINOS1/Mio10 as a novel constituent of Mitofilin/Fcj1 complexes in human and yeast mitochondria.
      Title: MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial crista junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mic10p
    NP_065435.1
    • Conserved component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic12p and Mic27p whose assembly and stability requires cardiolipin; homo-oligomers cause membrane bending; ortholog of human MINOS1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      24032..24325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184448.1 → NP_065435.1  TPA: Mic10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_065435.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQV9, Q96VH5
      UniProtKB/TrEMBL
      A0A6A5Q453, A6ZTD7, B3LU27, C7GT12, C8Z433, G2W9X0, N1PAQ4
      Conserved Domains (1) summary
      pfam04418
      Location:4 → 87
      DUF543; Domain of unknown function (DUF543)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96VH5.1

    Gene LinkOut

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