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    PPFIA2 PTPRF interacting protein alpha 2 [ Homo sapiens (human) ]

    Gene ID: 8499, updated on 2-Nov-2024

    Summary

    Official Symbol
    PPFIA2provided by HGNC
    Official Full Name
    PTPRF interacting protein alpha 2provided by HGNC
    Primary source
    HGNC:HGNC:9246
    See related
    Ensembl:ENSG00000139220 MIM:603143; AllianceGenome:HGNC:9246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Biased expression in brain (RPKM 7.4), adrenal (RPKM 1.4) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PPFIA2 in Genome Data Viewer
    Location:
    12q21.31
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (81257975..81759350, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (81236956..81738412, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (81651754..82153129, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984535 Neighboring gene NANOG hESC enhancer GRCh37_chr12:81489283-81489784 Neighboring gene acyl-CoA synthetase short chain family member 3 Neighboring gene NANOG hESC enhancer GRCh37_chr12:81602215-81602716 Neighboring gene microRNA 4699 Neighboring gene PPFIA2 antisense RNA 1 Neighboring gene uncharacterized LOC105369872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:82005227-82005726 Neighboring gene NANOG hESC enhancer GRCh37_chr12:82087706-82088318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:82151989-82152927 Neighboring gene vomeronasal 1 receptor 57 pseudogene Neighboring gene long intergenic non-protein coding RNA 2426

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study of multiplex schizophrenia pedigrees.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 (PPFIA2) is important for HIV-1 replication PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ41378, MGC132572

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in dense core granule cytoskeletal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of postsynaptic density structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in presynaptic active zone TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    liprin-alpha-2
    Names
    protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001220473.3NP_001207402.1  liprin-alpha-2 isoform b

      See identical proteins and their annotated locations for NP_001207402.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the UTRs and coding region, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AB210009, AW304872, BM661844
      Consensus CDS
      CCDS59236.1
      UniProtKB/TrEMBL
      G3V200, Q4LE62
      Related
      ENSP00000449558.2, ENST00000550584.6
      Conserved Domains (4) summary
      cd09562
      Location:895965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10191084
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11041175
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:201533
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. NM_001220474.3NP_001207403.1  liprin-alpha-2 isoform c

      See identical proteins and their annotated locations for NP_001207403.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the UTRs and coding region, compared to variant 1. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AB210009, AK126971, AW304872, BQ027545, CB051855, DA329958, EL947964
      Consensus CDS
      CCDS55854.1
      UniProtKB/TrEMBL
      Q4LE62
      Related
      ENSP00000450298.1, ENST00000549325.5
      Conserved Domains (5) summary
      cd09562
      Location:880950
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10041069
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10891160
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:183515
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05622
      Location:41272
      HOOK; HOOK protein
    3. NM_001220475.2NP_001207404.1  liprin-alpha-2 isoform d

      See identical proteins and their annotated locations for NP_001207404.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform d, which is shorter than isoform a.
      Source sequence(s)
      AB210009, AW304872, BC104912, BM661844, CB051855, EL947964
      Consensus CDS
      CCDS55855.1
      UniProtKB/TrEMBL
      Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:9981063
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10831154
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:201533
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_001220476.2NP_001207405.1  liprin-alpha-2 isoform e

      See identical proteins and their annotated locations for NP_001207405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform e, which is shorter than isoform a.
      Source sequence(s)
      AB210009, AW304872, BC143485, BM661844, CB051855, EL947964
      Consensus CDS
      CCDS55856.1
      UniProtKB/TrEMBL
      Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10131078
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10981169
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:201533
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001220477.2NP_001207406.1  liprin-alpha-2 isoform f

      See identical proteins and their annotated locations for NP_001207406.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform f, which is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK299853, AL713132, AW304872, BM661844, CB051855, DA329958, EL947964
      Consensus CDS
      CCDS55853.1
      UniProtKB/TrEMBL
      B7Z7Y5
      Related
      ENSP00000385093.4, ENST00000407050.8
      Conserved Domains (4) summary
      cd09562
      Location:821891
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:918983
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10031074
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127459
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    6. NM_001220478.2NP_001207407.1  liprin-alpha-2 isoform g

      See identical proteins and their annotated locations for NP_001207407.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform g, which is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK294505, AL713132, AW304872, BM661844, CB051855, DA687865, DC321269, EL947964
      Consensus CDS
      CCDS55852.1
      UniProtKB/TrEMBL
      B7Z7Y5
      Related
      ENSP00000327416.8, ENST00000333447.11
      Conserved Domains (5) summary
      cd09562
      Location:796866
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:914979
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:9991070
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:94434
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:323589
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    7. NM_001220479.3NP_001207408.1  liprin-alpha-2 isoform h

      See identical proteins and their annotated locations for NP_001207408.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform h, which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK296380, AW304872, BM661844, CB051855, EL947964
      Consensus CDS
      CCDS55851.1
      UniProtKB/Swiss-Prot
      O75334
      Related
      ENSP00000438337.2, ENST00000541570.6
      Conserved Domains (4) summary
      cd09562
      Location:462532
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:555620
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:640711
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:7264
      SMC_N; RecF/RecN/SMC N terminal domain
    8. NM_001220480.3NP_001207409.1  liprin-alpha-2 isoform i

      See identical proteins and their annotated locations for NP_001207409.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) has multiple differences in the 5' UTR and coding region but maintains the reading frame, compared to variant 1. This results in a shorter protein (isoform i), compared to isoform a.
      Source sequence(s)
      AK123372, AW304872, BM689808, CB051855, DC322478, EL947964
      Consensus CDS
      CCDS55850.1
      UniProtKB/Swiss-Prot
      O75334
      Related
      ENSP00000445532.1, ENST00000541017.5
      Conserved Domains (3) summary
      cd09562
      Location:112182
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:205270
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:290361
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    9. NM_001282536.1NP_001269465.1  liprin-alpha-2 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (j) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK302658, AW304872, BM661844, BU568524, CB051855, DB083201, EL947964
      Consensus CDS
      CCDS73503.1
      UniProtKB/TrEMBL
      B7Z7Y5, H0YHK3
      Related
      ENSP00000447273.2, ENST00000550359.6
      Conserved Domains (4) summary
      cd09562
      Location:742812
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:866931
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:9511022
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:36380
      SMC_N; RecF/RecN/SMC N terminal domain
    10. NM_003625.5NP_003616.2  liprin-alpha-2 isoform a

      See identical proteins and their annotated locations for NP_003616.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC079408, AF034799, AW304872, BM661844, CB051855, DA329958, DA368637, DA533482, EL947964
      Consensus CDS
      CCDS55857.1
      UniProtKB/Swiss-Prot
      B3KVT5, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, O75334, Q2M3G8
      UniProtKB/TrEMBL
      Q4LE62
      Related
      ENSP00000450337.1, ENST00000549396.6
      Conserved Domains (4) summary
      cd09562
      Location:895965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10191084
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11041175
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:201533
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      81257975..81759350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449242.2XP_024305010.1  liprin-alpha-2 isoform X30

      UniProtKB/TrEMBL
      Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:9881053
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10731144
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:201533
      SMC_N; RecF/RecN/SMC N terminal domain
    2. XM_017020107.3XP_016875596.1  liprin-alpha-2 isoform X27

      UniProtKB/TrEMBL
      Q4LE62
    3. XM_024449240.2XP_024305008.1  liprin-alpha-2 isoform X14

      UniProtKB/TrEMBL
      Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10091074
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10941165
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:201533
      SMC_N; RecF/RecN/SMC N terminal domain
    4. XM_017020090.3XP_016875579.1  liprin-alpha-2 isoform X11

      UniProtKB/TrEMBL
      Q4LE62
    5. XM_017020086.2XP_016875575.1  liprin-alpha-2 isoform X7

      UniProtKB/TrEMBL
      G3V200, Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:10191084
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:11041175
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:201533
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    6. XM_017020108.3XP_016875597.1  liprin-alpha-2 isoform X29

      UniProtKB/TrEMBL
      Q4LE62
    7. XM_047429786.1XP_047285742.1  liprin-alpha-2 isoform X20

    8. XM_047429781.1XP_047285737.1  liprin-alpha-2 isoform X12

    9. XM_047429778.1XP_047285734.1  liprin-alpha-2 isoform X9

    10. XM_047429775.1XP_047285731.1  liprin-alpha-2 isoform X5

    11. XM_017020099.2XP_016875588.1  liprin-alpha-2 isoform X19

      UniProtKB/TrEMBL
      Q4LE62
    12. XM_017020105.2XP_016875594.1  liprin-alpha-2 isoform X26

      UniProtKB/TrEMBL
      Q4LE62
    13. XM_047429791.1XP_047285747.1  liprin-alpha-2 isoform X31

    14. XM_017020103.3XP_016875592.1  liprin-alpha-2 isoform X22

      UniProtKB/TrEMBL
      Q4LE62
    15. XM_017020088.2XP_016875577.1  liprin-alpha-2 isoform X10

      UniProtKB/TrEMBL
      Q4LE62
    16. XM_047429788.1XP_047285744.1  liprin-alpha-2 isoform X23

    17. XM_047429785.1XP_047285741.1  liprin-alpha-2 isoform X18

    18. XM_017020094.3XP_016875583.1  liprin-alpha-2 isoform X16

      UniProtKB/TrEMBL
      Q4LE62
    19. XM_024449241.2XP_024305009.1  liprin-alpha-2 isoform X28

      UniProtKB/TrEMBL
      Q4LE62
      Conserved Domains (4) summary
      cd09562
      Location:895965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:9821047
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:10671138
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:201533
      SMC_N; RecF/RecN/SMC N terminal domain
    20. XM_047429789.1XP_047285745.1  liprin-alpha-2 isoform X24

    21. XM_047429783.1XP_047285739.1  liprin-alpha-2 isoform X15

      Related
      ENSP00000447868.1, ENST00000552948.5
    22. XM_047429777.1XP_047285733.1  liprin-alpha-2 isoform X8

    23. XM_047429774.1XP_047285730.1  liprin-alpha-2 isoform X4

      Related
      ENSP00000449338.1, ENST00000548586.5
    24. XM_047429790.1XP_047285746.1  liprin-alpha-2 isoform X25

    25. XM_047429787.1XP_047285743.1  liprin-alpha-2 isoform X21

    26. XM_047429784.1XP_047285740.1  liprin-alpha-2 isoform X17

    27. XM_047429782.1XP_047285738.1  liprin-alpha-2 isoform X13

    28. XM_047429776.1XP_047285732.1  liprin-alpha-2 isoform X6

    29. XM_047429773.1XP_047285729.1  liprin-alpha-2 isoform X3

    30. XM_047429770.1XP_047285726.1  liprin-alpha-2 isoform X1

    31. XM_047429796.1XP_047285752.1  liprin-alpha-2 isoform X38

    32. XM_047429795.1XP_047285751.1  liprin-alpha-2 isoform X37

    33. XM_047429780.1XP_047285736.1  liprin-alpha-2 isoform X10

    34. XM_047429772.1XP_047285728.1  liprin-alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      B3KVT5, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, O75334, Q2M3G8
    35. XM_047429771.1XP_047285727.1  liprin-alpha-2 isoform X1

    36. XM_017020118.2XP_016875607.1  liprin-alpha-2 isoform X33

      UniProtKB/TrEMBL
      B7Z7Y5
    37. XM_047429794.1XP_047285750.1  liprin-alpha-2 isoform X34

    38. XM_047429793.1XP_047285749.1  liprin-alpha-2 isoform X32

    39. XM_047429792.1XP_047285748.1  liprin-alpha-2 isoform X32

    40. XM_024449245.2XP_024305013.1  liprin-alpha-2 isoform X36

      Conserved Domains (4) summary
      cd09562
      Location:490560
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:614679
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:699770
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      cl25732
      Location:1289
      SMC_N; RecF/RecN/SMC N terminal domain
    41. XM_024449244.2XP_024305012.1  liprin-alpha-2 isoform X35

      Conserved Domains (1) summary
      cl25732
      Location:201533
      SMC_N; RecF/RecN/SMC N terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      81236956..81738412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373675.1XP_054229650.1  liprin-alpha-2 isoform X30

    2. XM_054373672.1XP_054229647.1  liprin-alpha-2 isoform X27

    3. XM_054373658.1XP_054229633.1  liprin-alpha-2 isoform X11

    4. XM_054373654.1XP_054229629.1  liprin-alpha-2 isoform X7

      UniProtKB/TrEMBL
      G3V200
    5. XM_054373674.1XP_054229649.1  liprin-alpha-2 isoform X29

    6. XM_054373665.1XP_054229640.1  liprin-alpha-2 isoform X20

    7. XM_054373655.1XP_054229630.1  liprin-alpha-2 isoform X9

    8. XM_054373653.1XP_054229628.1  liprin-alpha-2 isoform X5

    9. XM_054373664.1XP_054229639.1  liprin-alpha-2 isoform X19

    10. XM_054373671.1XP_054229646.1  liprin-alpha-2 isoform X26

    11. XM_054373676.1XP_054229651.1  liprin-alpha-2 isoform X31

    12. XM_054373667.1XP_054229642.1  liprin-alpha-2 isoform X22

    13. XM_054373656.1XP_054229631.1  liprin-alpha-2 isoform X10

    14. XM_054373668.1XP_054229643.1  liprin-alpha-2 isoform X23

    15. XM_054373663.1XP_054229638.1  liprin-alpha-2 isoform X18

    16. XM_054373661.1XP_054229636.1  liprin-alpha-2 isoform X16

    17. XM_054373673.1XP_054229648.1  liprin-alpha-2 isoform X28

    18. XM_054373669.1XP_054229644.1  liprin-alpha-2 isoform X24

    19. XM_054373660.1XP_054229635.1  liprin-alpha-2 isoform X15

    20. XM_054373652.1XP_054229627.1  liprin-alpha-2 isoform X4

    21. XM_054373670.1XP_054229645.1  liprin-alpha-2 isoform X25

    22. XM_054373666.1XP_054229641.1  liprin-alpha-2 isoform X21

    23. XM_054373662.1XP_054229637.1  liprin-alpha-2 isoform X17

    24. XM_054373659.1XP_054229634.1  liprin-alpha-2 isoform X13

    25. XM_054373651.1XP_054229626.1  liprin-alpha-2 isoform X3

    26. XM_054373648.1XP_054229623.1  liprin-alpha-2 isoform X1

    27. XM_054373684.1XP_054229659.1  liprin-alpha-2 isoform X38

    28. XM_054373683.1XP_054229658.1  liprin-alpha-2 isoform X37

    29. XM_054373657.1XP_054229632.1  liprin-alpha-2 isoform X10

    30. XM_054373650.1XP_054229625.1  liprin-alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      B3KVT5, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, O75334, Q2M3G8
    31. XM_054373649.1XP_054229624.1  liprin-alpha-2 isoform X1

    32. XM_054373679.1XP_054229654.1  liprin-alpha-2 isoform X33

    33. XM_054373680.1XP_054229655.1  liprin-alpha-2 isoform X34

    34. XM_054373678.1XP_054229653.1  liprin-alpha-2 isoform X32

    35. XM_054373677.1XP_054229652.1  liprin-alpha-2 isoform X32

    36. XM_054373682.1XP_054229657.1  liprin-alpha-2 isoform X36

    37. XM_054373681.1XP_054229656.1  liprin-alpha-2 isoform X35