ING5 inhibitor of growth family member 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ING5provided by HGNC
Official Full Name: inhibitor of growth family member 5provided by HGNC
Primary source: HGNC:HGNC:19421
See related: Ensembl:ENSG00000168395 MIM:608525; AllianceGenome:HGNC:19421
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p28ING5
Summary: This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Expression: Ubiquitous expression in ovary (RPKM 3.6), skin (RPKM 3.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q37.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (241687020..241729478)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (242190352..242233501)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (242626435..242668893)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ING5 overexpression upregulates miR-34c-5p/Snail1 to inhibit EMT and invasion of lung cancer cells.
Title: ING5 overexpression upregulates miR-34c-5p/Snail1 to inhibit EMT and invasion of lung cancer cells.
Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5.
Title: Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5.
ING5 Inhibits Migration and Invasion of Esophageal Cancer Cells by Downregulating the IL-6/CXCL12 Signaling Pathway.
Title: ING5 Inhibits Migration and Invasion of Esophageal Cancer Cells by Downregulating the IL-6/CXCL12 Signaling Pathway.
MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer.
Title: MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer.
LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis.
Title: LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis.
The data suggest that miR-376c-3p downregulated ING5 to exert protective effects against oxygen-glucose deprivation-induced cell injury in cultured human and rat cells.
Title: Upregulation of miR-376c-3p alleviates oxygen-glucose deprivation-induced cell injury by targeting ING5.
ING5 forms homodimers through its N-terminal domain, which folds independently into an elongated coiled-coil structure.
Title: The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
Results show that ING5 overexpression promotes phosphorylation-dependent degradation of beta-catenin, leading to downregulated Wnt/beta- catenin signaling and inhibition of lung cancer invasion and epithelial-mesenchymal transition.
Title: ING5 inhibits lung cancer invasion and epithelial-mesenchymal transition by inhibiting the WNT/β-catenin pathway.
The Hepatitis B virus X protein (HBx) downregulates the expression of the miR-181b target gene ING5, resulting in the promotion of HCC cell proliferation.
Title: Hepatitis B virus X protein promotes proliferation of hepatocellular carcinoma cells by upregulating miR-181b by targeting ING5.
our results demonstrate, for the first time that overexpression of ING5 in osteosarcoma cells induces apoptosis
Title: ING5 is a Potential Target for Osteosarcoma Therapy.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH76740 (e-PCR)
- UniSTS:90919

D8S2278 (e-PCR)
- UniSTS:473906

SHGC-148535 (e-PCR)
- UniSTS:176446

L18426 (e-PCR)
- UniSTS:34648

L17877 (e-PCR)
- UniSTS:61334

L17971 (e-PCR)
- UniSTS:43966

SHGC-64331 (e-PCR)
- UniSTS:67544

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication-dependent chromatin disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of growth	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of developmental process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of hemopoiesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of MOZ/MORF histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone acetyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inhibitor of growth protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330161.2 → NP_001317090.1 inhibitor of growth protein 5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate promoter and differs in the 3' exon structure, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is longer than isoform 1.

Source sequence(s)

AC114730, AC133528

Consensus CDS

CCDS82585.1

UniProtKB/TrEMBL

A0A1B0GW41

Related

ENSP00000490767.1, ENST00000636051.1
NM_001330162.2 → NP_001317091.1 inhibitor of growth protein 5 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' terminal exon compared to variant 1. The encoded isoform (3) has a shorter C-terminus than isoform 1.

Source sequence(s)

AC114730, AC133528, BC005370

Consensus CDS

CCDS82586.1

UniProtKB/Swiss-Prot

Q8WYH8

Related

ENSP00000385937.1, ENST00000406941.5

Conserved Domains (2) summary

cd15586
Location:188 → 226

PHD_ING4_5; PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5)

cd16863
Location:12 → 104

ING_ING5; Inhibitor of growth (ING) domain of inhibitor of growth protein 5 (ING5)
NM_032329.6 → NP_115705.2 inhibitor of growth protein 5 isoform 1

See identical proteins and their annotated locations for NP_115705.2

Status: REVIEWED

Source sequence(s)

AC133528, AF189286, AI701412, AK074422, AK128322, BC039028, BI962551, BQ187350

Consensus CDS

CCDS33425.1

UniProtKB/Swiss-Prot

A8K1P3, Q53NU6, Q57Z54, Q8WYH8, Q9BS30

Related

ENSP00000322142.7, ENST00000313552.11

Conserved Domains (2) summary

cd15685
Location:187 → 235

PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)

cd16863
Location:12 → 104

ING_ING5; Inhibitor of growth (ING) domain of inhibitor of growth protein 5 (ING5)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

241687020..241729478

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047446012.1 → XP_047301968.1 inhibitor of growth protein 5 isoform X5
XM_047446014.1 → XP_047301970.1 inhibitor of growth protein 5 isoform X7
XM_047446013.1 → XP_047301969.1 inhibitor of growth protein 5 isoform X6
XM_017005102.3 → XP_016860591.1 inhibitor of growth protein 5 isoform X8

UniProtKB/TrEMBL

B7Z6R2

Conserved Domains (1) summary

pfam12998
Location:6 → 105

ING; Inhibitor of growth proteins N-terminal histone-binding
XM_047446011.1 → XP_047301967.1 inhibitor of growth protein 5 isoform X4

Related

ENST00000482774.5
XM_017005098.2 → XP_016860587.1 inhibitor of growth protein 5 isoform X3
XM_017005097.2 → XP_016860586.1 inhibitor of growth protein 5 isoform X2
XM_047446010.1 → XP_047301966.1 inhibitor of growth protein 5 isoform X1