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    ARF1 auxin response factor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842268, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARF1
    Official Full Name
    auxin response factor 1
    Primary source
    TAIR:AT1G59750
    Locus tag
    AT1G59750
    See related
    Araport:AT1G59750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    auxin response factor 1; F23H11.7; F23H11_7
    Summary
    Encodes a member of the auxin response factor family. ARFs bind to the cis element 5'-TGTCTC-3' ARFs mediate changes in gene expression in response to auxin. ARF's form heterodimers with IAA/AUX genes. ARF1 enhances mutant phenotypes of ARF2 and may act with ARF2 to control aspects of maturation and senescence.ARF1:LUC and 3xHA:ARF1 proteins have a half-life of ~3-4 hours and their degradation is reduced by proteasome inhibitors. 3xHA:ARF1 degradation is not affected by a pre-treatment with IAA. A nuclear-targeted fusion protein containing the middle region of ARF1 linked to LUC:NLS has a similar half-life to the full-length ARF1:LUC construct. The degradation of 3xHA:ARF1 is not affected in an axr6-3 mutant grown at room temperature, although the degradation of AXR2/IAA7 is slowed under these conditions.
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    Genomic context

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    See ARF1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Sequence:
    Chromosome: 1; NC_003070.9 (21979289..21984433)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene thioredoxin H-type 7 Neighboring gene Major facilitator superfamily protein Neighboring gene RNA helicase, ATP-dependent, SK12/DOB1 protein Neighboring gene pseudo Neighboring gene NB-ARC domain-containing disease resistance protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Architecture of DNA elements mediating ARF transcription factor binding and auxin-responsive gene expression in Arabidopsis. Freire-Rios A, et al. Proc Natl Acad Sci U S A, 2020 Sep 29. PMID 32929017, Free PMC Article
    2. ADP ribosylation factor 1 plays an essential role in the replication of a plant RNA virus. Hyodo K, et al. J Virol, 2013 Jan. PMID 23097452, Free PMC Article
    3. Degradation of the auxin response factor ARF1. Salmon J, et al. Plant J, 2008 Apr. PMID 18088308
    4. Coordinated Activation of ARF1 GTPases by ARF-GEF GNOM Dimers Is Essential for Vesicle Trafficking in Arabidopsis. Brumm S, et al. Plant Cell, 2020 Aug. PMID 32487565, Free PMC Article
    5. The nuclear localized RIN13 induces cell death through interacting with ARF1. Liu X, et al. Biochem Biophys Res Commun, 2020 Jun 18. PMID 32446355

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YUCCA2 (YUC2)-Mediated 3-Indoleacetic Acid (IAA) Biosynthesis Regulates Chloroplast RNA Editing by Relieving the Auxin Response Factor 1 (ARF1)-Dependent Inhibition of Editing Factors in Arabidopsis thaliana.
      Title: YUCCA2 (YUC2)-Mediated 3-Indoleacetic Acid (IAA) Biosynthesis Regulates Chloroplast RNA Editing by Relieving the Auxin Response Factor 1 (ARF1)-Dependent Inhibition of Editing Factors in Arabidopsis thaliana.
    2. Coordinated Activation of ARF1 GTPases by ARF-GEF GNOM Dimers Is Essential for Vesicle Trafficking in Arabidopsis.
      Title: Coordinated Activation of ARF1 GTPases by ARF-GEF GNOM Dimers Is Essential for Vesicle Trafficking in Arabidopsis.
    3. Architecture of DNA elements mediating ARF transcription factor binding and auxin-responsive gene expression in Arabidopsis.
      Title: Architecture of DNA elements mediating ARF transcription factor binding and auxin-responsive gene expression in Arabidopsis.
    4. Data show that IAA8 is involved in lateral root formation, and that this process is regulated through the interaction with the TIR1 auxin receptor and ARF transcription factors in the nucleus.
      Title: IAA8 involved in lateral root formation interacts with the TIR1 auxin receptor and ARF transcription factors in Arabidopsis.
    5. The authors showed that Arf1 interacted with the viral p27 replication protein within the virus-induced large punctate structures of the endoplasmic reticulum membrane.
      Title: ADP ribosylation factor 1 plays an essential role in the replication of a plant RNA virus.
    6. The half-life of degradation of ARF1, and its role in auxin metabolism, are reported.
      Title: Degradation of the auxin response factor ARF1.
    7. unlike arf2 mutations, an arf1 mutation increased transcription of Aux/IAA genes in Arabidopsis flowers, supporting previous biochemical studies that indicated that ARF1 is a transcriptional repressor
      Title: AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036131.3
    NM_001198337.1
    NM_104668.4
    NM_179499.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf senescence IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    auxin response factor 1
    NP_001031208.1
    • auxin response factor 1 (ARF1); CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 11 (TAIR:AT2G46530.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001185266.1
    • auxin response factor 1 (ARF1); CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 11 (TAIR:AT2G46530.3).
    NP_176184.1
    • auxin response factor 1 (ARF1); CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 11 (TAIR:AT2G46530.1); Has 2491 Blast hits to 2147 proteins in 119 species: Archae - 0; Bacteria - 28; Metazoa - 9; Fungi - 9; Plants - 2417; Viruses - 4; Other Eukaryotes - 24 (source: NCBI BLink).
    NP_849830.1
    • auxin response factor 1 (ARF1); CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 11 (TAIR:AT2G46530.3); Has 2481 Blast hits to 2103 proteins in 109 species: Archae - 0; Bacteria - 12; Metazoa - 22; Fungi - 4; Plants - 2392; Viruses - 0; Other Eukaryotes - 51 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      21979289..21984433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198337.1 → NP_001185266.1  auxin response factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185266.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E508, F4ID31
      Conserved Domains (3) summary
      pfam02309
      Location:541 → 616
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:124 → 225
      B3; B3 DNA binding domain
      pfam06507
      Location:250 → 332
      Auxin_resp; Auxin response factor

    2. NM_001036131.3 → NP_001031208.1  auxin response factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23664, Q8L7G0
      UniProtKB/TrEMBL
      A0A178WF94, A0A654EJH5, B9DGM9
      Conserved Domains (4) summary
      pfam02309
      Location:525 → 621
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:124 → 225
      B3; B3 DNA binding domain
      pfam06507
      Location:250 → 332
      Auxin_resp; Auxin response factor
      pfam11679
      Location:343 → 419
      DUF3275; Protein of unknown function (DUF3275)

    3. NM_104668.4 → NP_176184.1  auxin response factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176184.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23664, Q8L7G0
      UniProtKB/TrEMBL
      A0A178WF94, A0A654EJH5, B9DGM9
      Conserved Domains (4) summary
      pfam02309
      Location:525 → 621
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:124 → 225
      B3; B3 DNA binding domain
      pfam06507
      Location:250 → 332
      Auxin_resp; Auxin response factor
      pfam11679
      Location:343 → 419
      DUF3275; Protein of unknown function (DUF3275)

    4. NM_179499.2 → NP_849830.1  auxin response factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WNB3, A0A7G2E508
      Conserved Domains (4) summary
      PHA03247
      Location:344 → 419
      PHA03247; large tegument protein UL36; Provisional
      pfam02309
      Location:522 → 618
      AUX_IAA; AUX/IAA family
      pfam02362
      Location:124 → 225
      B3; B3 DNA binding domain
      pfam06507
      Location:250 → 332
      Auxin_resp; Auxin response factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L7G0.2

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