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    OZS1 C4-dicarboxylate transporter/malic acid transport protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837805, updated on 18-Sep-2024

    Summary

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    Official Symbol
    OZS1
    Official Full Name
    C4-dicarboxylate transporter/malic acid transport protein
    Primary source
    TAIR:AT1G12480
    Locus tag
    AT1G12480
    See related
    Araport:AT1G12480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CARBON DIOXIDE INSENSITIVE 3; CDI3; F5O11.23; F5O11_23; OZONE-SENSITIVE 1; RADICAL-INDUCED CELL DEATH 3; RCD3; SLAC1; SLOW ANION CHANNEL-ASSOCIATED 1
    Summary
    Encodes a membrane protein with 10 predicted transmembrane helices. SLAC1 is a multispanning membrane protein expressed predominantly in guard cells that plays a role in regulating cellular ion homeostasis and S-type anion currents. SLAC1 is important for normal stomatal closure in response to a variety of signals including elevated CO2, ozone, ABA, darkness, and humidity. SLAC1:GFP localizes to the plasma membrane.
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    Genomic context

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    See OZS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (4257268..4259300, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene SNARE associated Golgi protein family Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model. Lee Y, et al. Nat Commun, 2023 Nov 14. PMID 37963863, Free PMC Article
    2. Structure and activity of SLAC1 channels for stomatal signaling in leaves. Deng YN, et al. Proc Natl Acad Sci U S A, 2021 May 4. PMID 33926963, Free PMC Article
    3. Disruption of a gene encoding C4-dicarboxylate transporter-like protein increases ozone sensitivity through deregulation of the stomatal response in Arabidopsis thaliana. Saji S, et al. Plant Cell Physiol, 2008 Jan. PMID 18084014
    4. SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling. Vahisalu T, et al. Nature, 2008 Mar 27. PMID 18305484, Free PMC Article
    5. Alteration of Arabidopsis SLAC1 promoter and its association with natural variation in drought tolerance. Imai H, et al. Plant Signal Behav, 2015. PMID 25695335, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
      Title: Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
    2. The CIPK23 protein kinase represses SLAC1-type anion channels in Arabidopsis guard cells and stimulates stomatal opening.
      Title: The CIPK23 protein kinase represses SLAC1-type anion channels in Arabidopsis guard cells and stimulates stomatal opening.
    3. Structure and activity of SLAC1 channels for stomatal signaling in leaves.
      Title: Structure and activity of SLAC1 channels for stomatal signaling in leaves.
    4. STRESS INDUCED FACTOR 2 Regulates Arabidopsis Stomatal Immunity through Phosphorylation of the Anion Channel SLAC1.
      Title: STRESS INDUCED FACTOR 2 Regulates Arabidopsis Stomatal Immunity through Phosphorylation of the Anion Channel SLAC1.
    5. SLAC1 activation by CPK6 or CBL5-CIPK11 was strictly dependent on dual lipid modification.
      Title: N-myristoylation and S-acylation are common modifications of Ca(2+) -regulated Arabidopsis kinases and are required for activation of the SLAC1 anion channel.
    6. Surveying in the locus, we extrapolated that the SLAC1 gene, which is associated with stomatal closure, was likely responsible for the difference of drought tolerance.
      Title: Alteration of Arabidopsis SLAC1 promoter and its association with natural variation in drought tolerance.
    7. SLAC1 is required for rapid stomatal closure in response to ozone, reduced air humidity and darkness.
      Title: PYR/RCAR receptors contribute to ozone-, reduced air humidity-, darkness-, and CO2-induced stomatal regulation.
    8. The predictive power of a systems dynamic model in Arabidopsis, is demonstrated to explain the paradoxical suppression of channels that facilitate K(+) uptake, slowing stomatal opening, by mutation of the SLAC1 anion channel.
      Title: Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration.
    9. Guard cells with mutations in slac1 exhibit dramatically reduced inwardly-rectifying K+ channel currents. Decreasing the cytosolic Ca2+ concentration rapidly restores K+ channel currents in slac1 guard cells.
      Title: Mutations in the SLAC1 anion channel slow stomatal opening and severely reduce K+ uptake channel activity via enhanced cytosolic [Ca2+] and increased Ca2+ sensitivity of K+ uptake channels.
    10. Data suggest that SLAC1 may be a pathway providing CO(2) for photosynthesis in the guard cells.
      Title: A possible CO2 conducting and concentrating mechanism in plant stomata SLAC1 channel.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101120.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables monoatomic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated monoatomic anion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular monoatomic ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic anion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organismal-level water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal opening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to carbon dioxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to humidity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ozone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C4-dicarboxylate transporter/malic acid transport protein
    NP_563909.1
    • OZONE-SENSITIVE 1 (OZS1); CONTAINS InterPro DOMAIN/s: C4-dicarboxylate transporter/malic acid transport protein (InterPro:IPR004695); BEST Arabidopsis thaliana protein match is: SLAC1 homologue 3 (TAIR:AT5G24030.1); Has 903 Blast hits to 900 proteins in 365 species: Archae - 17; Bacteria - 650; Metazoa - 0; Fungi - 31; Plants - 165; Viruses - 0; Other Eukaryotes - 40 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4257268..4259300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101120.3 → NP_563909.1  C4-dicarboxylate transporter/malic acid transport protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563909.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LD83
      UniProtKB/TrEMBL
      A0A178WLC1, A0A5S9U2E9, A0A654EA22
      Conserved Domains (1) summary
      cd09323
      Location:187 → 493
      TDT_SLAC1_like; Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LD83.1

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