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    HEN4 RNA-binding KH domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836560, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEN4
    Official Full Name
    RNA-binding KH domain-containing protein
    Primary source
    TAIR:AT5G64390
    Locus tag
    AT5G64390
    See related
    Araport:AT5G64390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HUA ENHANCER 4; MSJ1.23; MSJ1_23
    Summary
    encodes a K homology (KH) domain-containing, putative RNA binding protein that interacts with HUA1, a CCCH zinc finger RNA binding protein in the nucleus. HEN4 acts redundantly with HUA1 and HUA2 in the specification of floral organ identity in the third whorl.
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    Genomic context

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    See HEN4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (25743344..25748575)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene beta-ureidopropionase Neighboring gene Inositol monophosphatase family protein Neighboring gene CHCH domain protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene oligopeptide transporter 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis HUA ENHANCER 4 delays flowering by upregulating the MADS-box repressor genes FLC and MAF4. Ortuño-Miquel S, et al. Sci Rep, 2019 Feb 6. PMID 30728422, Free PMC Article
    2. Regulation of flowering time in Arabidopsis by K homology domain proteins. Mockler TC, et al. Proc Natl Acad Sci U S A, 2004 Aug 24. PMID 15310842, Free PMC Article
    3. Two RNA binding proteins, HEN4 and HUA1, act in the processing of AGAMOUS pre-mRNA in Arabidopsis thaliana. Cheng Y, et al. Dev Cell, 2003 Jan. PMID 12530963, Free PMC Article
    4. K-homology nuclear ribonucleoproteins regulate floral organ identity and determinacy in arabidopsis. Rodríguez-Cazorla E, et al. PLoS Genet, 2015 Feb. PMID 25658099, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis HUA ENHANCER 4 delays flowering by upregulating the MADS-box repressor genes FLC and MAF4.
      Title: Arabidopsis HUA ENHANCER 4 delays flowering by upregulating the MADS-box repressor genes FLC and MAF4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203683.1
    NM_125835.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in maintenance of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within specification of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding KH domain-containing protein
    NP_001190612.1
    • HUA ENHANCER 4 (HEN4); CONTAINS InterPro DOMAIN/s: K Homology (InterPro:IPR004087), K Homology, type 1, subgroup (InterPro:IPR018111), K Homology, type 1 (InterPro:IPR004088); BEST Arabidopsis thaliana protein match is: RNA-binding KH domain-containing protein (TAIR:AT5G09560.1).
    NP_201244.2
    • HUA ENHANCER 4 (HEN4); CONTAINS InterPro DOMAIN/s: K Homology, type 1, subgroup (InterPro:IPR018111), K Homology (InterPro:IPR004087), K Homology, type 1 (InterPro:IPR004088); BEST Arabidopsis thaliana protein match is: RNA-binding KH domain-containing protein (TAIR:AT5G09560.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974990.1
    • HUA ENHANCER 4 (HEN4); CONTAINS InterPro DOMAIN/s: K Homology, type 1, subgroup (InterPro:IPR018111), K Homology (InterPro:IPR004087), K Homology, type 1 (InterPro:IPR004088); BEST Arabidopsis thaliana protein match is: RNA-binding KH domain-containing protein (TAIR:AT5G09560.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25743344..25748575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_203261.2 → NP_974990.1  RNA-binding KH domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974990.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KDN1, Q84ZW9
      Conserved Domains (1) summary
      cd02396
      Location:49 → 102
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    2. NM_125835.5 → NP_201244.2  RNA-binding KH domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201244.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KDN0, Q9FMF0
      UniProtKB/TrEMBL
      A0A654GE96
      Conserved Domains (2) summary
      cd00105
      Location:777 → 840
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:49 → 102
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    3. NM_001203683.1 → NP_001190612.1  RNA-binding KH domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654GE96, F4KDM9
      Conserved Domains (2) summary
      cd00105
      Location:786 → 849
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:49 → 102
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4KDN0.1

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